Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3CW2

Crystal structure of the intact archaeal translation initiation factor 2 from Sulfolobus solfataricus .

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000049	molecular_function	tRNA binding
A	0001731	biological_process	formation of translation preinitiation complex
A	0003743	molecular_function	translation initiation factor activity
A	0003746	molecular_function	translation elongation factor activity
A	0003924	molecular_function	GTPase activity
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0006412	biological_process	translation
A	0006413	biological_process	translational initiation
A	0006414	biological_process	translational elongation
A	0016787	molecular_function	hydrolase activity
A	0046872	molecular_function	metal ion binding
B	0000049	molecular_function	tRNA binding
B	0001731	biological_process	formation of translation preinitiation complex
B	0003743	molecular_function	translation initiation factor activity
B	0003746	molecular_function	translation elongation factor activity
B	0003924	molecular_function	GTPase activity
B	0005515	molecular_function	protein binding
B	0005525	molecular_function	GTP binding
B	0006412	biological_process	translation
B	0006413	biological_process	translational initiation
B	0006414	biological_process	translational elongation
B	0016787	molecular_function	hydrolase activity
B	0046872	molecular_function	metal ion binding
C	0003676	molecular_function	nucleic acid binding
C	0003723	molecular_function	RNA binding
C	0003743	molecular_function	translation initiation factor activity
C	0005515	molecular_function	protein binding
C	0006412	biological_process	translation
C	0006413	biological_process	translational initiation
C	0043022	molecular_function	ribosome binding
D	0003676	molecular_function	nucleic acid binding
D	0003723	molecular_function	RNA binding
D	0003743	molecular_function	translation initiation factor activity
D	0005515	molecular_function	protein binding
D	0006412	biological_process	translation
D	0006413	biological_process	translational initiation
D	0043022	molecular_function	ribosome binding
E	0000049	molecular_function	tRNA binding
E	0001731	biological_process	formation of translation preinitiation complex
E	0003743	molecular_function	translation initiation factor activity
E	0003746	molecular_function	translation elongation factor activity
E	0003924	molecular_function	GTPase activity
E	0005515	molecular_function	protein binding
E	0005525	molecular_function	GTP binding
E	0006412	biological_process	translation
E	0006413	biological_process	translational initiation
E	0006414	biological_process	translational elongation
E	0016787	molecular_function	hydrolase activity
E	0046872	molecular_function	metal ion binding
F	0000049	molecular_function	tRNA binding
F	0001731	biological_process	formation of translation preinitiation complex
F	0003743	molecular_function	translation initiation factor activity
F	0003746	molecular_function	translation elongation factor activity
F	0003924	molecular_function	GTPase activity
F	0005515	molecular_function	protein binding
F	0005525	molecular_function	GTP binding
F	0006412	biological_process	translation
F	0006413	biological_process	translational initiation
F	0006414	biological_process	translational elongation
F	0016787	molecular_function	hydrolase activity
F	0046872	molecular_function	metal ion binding
G	0003676	molecular_function	nucleic acid binding
G	0003723	molecular_function	RNA binding
G	0003743	molecular_function	translation initiation factor activity
G	0005515	molecular_function	protein binding
G	0006412	biological_process	translation
G	0006413	biological_process	translational initiation
G	0043022	molecular_function	ribosome binding
H	0003676	molecular_function	nucleic acid binding
H	0003723	molecular_function	RNA binding
H	0003743	molecular_function	translation initiation factor activity
H	0005515	molecular_function	protein binding
H	0006412	biological_process	translation
H	0006413	biological_process	translational initiation
H	0043022	molecular_function	ribosome binding
K	0003743	molecular_function	translation initiation factor activity
K	0006412	biological_process	translation
K	0006413	biological_process	translational initiation
L	0003743	molecular_function	translation initiation factor activity
L	0006412	biological_process	translation
L	0006413	biological_process	translational initiation
M	0003743	molecular_function	translation initiation factor activity
M	0006412	biological_process	translation
M	0006413	biological_process	translational initiation
N	0003743	molecular_function	translation initiation factor activity
N	0006412	biological_process	translation
N	0006413	biological_process	translational initiation

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_00119, ECO:0000269\|PubMed:25690901, ECO:0007744\|PDB:4RD1

Chain	Residue	Details
A	ASP19
A	GLY44
B	ASP19
B	GLY44
E	ASP19
E	GLY44
F	ASP19
F	GLY44

site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_00119, ECO:0000269\|PubMed:16407071, ECO:0000269\|PubMed:25690901, ECO:0007744\|PDB:2AHO

Chain	Residue	Details
E	THR23
E	THR46
F	THR23
F	THR46
A	THR23
A	THR46
B	THR23
B	THR46

site_id	SWS_FT_FI3
Number of Residues	16
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:Q8U082, ECO:0000255\|HAMAP-Rule:MF_00119

Chain	Residue	Details
B	CYS77
E	CYS59
E	CYS62
E	CYS74
E	CYS77
F	CYS59
F	CYS62
F	CYS74
F	CYS77
A	CYS59
A	CYS62
A	CYS74
A	CYS77
B	CYS59
B	CYS62
B	CYS74

site_id	SWS_FT_FI4
Number of Residues	8
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_00119, ECO:0000269\|PubMed:25690901, ECO:0007744\|PDB:4RCY, ECO:0007744\|PDB:4RD1

Chain	Residue	Details
E	ASN149
E	SER184
F	ASN149
F	SER184
A	ASN149
A	SER184
B	ASN149
B	SER184

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)