3CVH

How TCR-like antibody recognizes MHC-bound peptide

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0001913	biological_process	T cell mediated cytotoxicity
B	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
B	0002237	biological_process	response to molecule of bacterial origin
B	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
B	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
B	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
B	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
B	0002726	biological_process	positive regulation of T cell cytokine production
B	0005198	molecular_function	structural molecule activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005765	cellular_component	lysosomal membrane
B	0005794	cellular_component	Golgi apparatus
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006826	biological_process	iron ion transport
B	0006879	biological_process	intracellular iron ion homeostasis
B	0006955	biological_process	immune response
B	0006968	biological_process	cellular defense response
B	0007608	biological_process	sensory perception of smell
B	0007611	biological_process	learning or memory
B	0009897	cellular_component	external side of plasma membrane
B	0010977	biological_process	negative regulation of neuron projection development
B	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
B	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
B	0023026	molecular_function	MHC class II protein complex binding
B	0030670	cellular_component	phagocytic vesicle membrane
B	0031902	cellular_component	late endosome membrane
B	0033077	biological_process	T cell differentiation in thymus
B	0034756	biological_process	regulation of iron ion transport
B	0042026	biological_process	protein refolding
B	0042605	molecular_function	peptide antigen binding
B	0042612	cellular_component	MHC class I protein complex
B	0042613	cellular_component	MHC class II protein complex
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0042824	cellular_component	MHC class I peptide loading complex
B	0045646	biological_process	regulation of erythrocyte differentiation
B	0048260	biological_process	positive regulation of receptor-mediated endocytosis
B	0050680	biological_process	negative regulation of epithelial cell proliferation
B	0050768	biological_process	negative regulation of neurogenesis
B	0050778	biological_process	positive regulation of immune response
B	0050870	biological_process	positive regulation of T cell activation
B	0051289	biological_process	protein homotetramerization
B	0060586	biological_process	multicellular organismal-level iron ion homeostasis
B	0071281	biological_process	cellular response to iron ion
B	0071283	biological_process	cellular response to iron(III) ion
B	0071316	biological_process	cellular response to nicotine
B	1990000	biological_process	amyloid fibril formation
B	1990712	cellular_component	HFE-transferrin receptor complex
B	2000774	biological_process	positive regulation of cellular senescence
B	2000978	biological_process	negative regulation of forebrain neuron differentiation
N	0001913	biological_process	T cell mediated cytotoxicity
N	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
N	0002237	biological_process	response to molecule of bacterial origin
N	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
N	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
N	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
N	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
N	0002726	biological_process	positive regulation of T cell cytokine production
N	0005198	molecular_function	structural molecule activity
N	0005515	molecular_function	protein binding
N	0005576	cellular_component	extracellular region
N	0005615	cellular_component	extracellular space
N	0005765	cellular_component	lysosomal membrane
N	0005794	cellular_component	Golgi apparatus
N	0005829	cellular_component	cytosol
N	0005886	cellular_component	plasma membrane
N	0006826	biological_process	iron ion transport
N	0006879	biological_process	intracellular iron ion homeostasis
N	0006955	biological_process	immune response
N	0006968	biological_process	cellular defense response
N	0007608	biological_process	sensory perception of smell
N	0007611	biological_process	learning or memory
N	0009897	cellular_component	external side of plasma membrane
N	0010977	biological_process	negative regulation of neuron projection development
N	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
N	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
N	0023026	molecular_function	MHC class II protein complex binding
N	0030670	cellular_component	phagocytic vesicle membrane
N	0031902	cellular_component	late endosome membrane
N	0033077	biological_process	T cell differentiation in thymus
N	0034756	biological_process	regulation of iron ion transport
N	0042026	biological_process	protein refolding
N	0042605	molecular_function	peptide antigen binding
N	0042612	cellular_component	MHC class I protein complex
N	0042613	cellular_component	MHC class II protein complex
N	0042802	molecular_function	identical protein binding
N	0042803	molecular_function	protein homodimerization activity
N	0042824	cellular_component	MHC class I peptide loading complex
N	0045646	biological_process	regulation of erythrocyte differentiation
N	0048260	biological_process	positive regulation of receptor-mediated endocytosis
N	0050680	biological_process	negative regulation of epithelial cell proliferation
N	0050768	biological_process	negative regulation of neurogenesis
N	0050778	biological_process	positive regulation of immune response
N	0050870	biological_process	positive regulation of T cell activation
N	0051289	biological_process	protein homotetramerization
N	0060586	biological_process	multicellular organismal-level iron ion homeostasis
N	0071281	biological_process	cellular response to iron ion
N	0071283	biological_process	cellular response to iron(III) ion
N	0071316	biological_process	cellular response to nicotine
N	1990000	biological_process	amyloid fibril formation
N	1990712	cellular_component	HFE-transferrin receptor complex
N	2000774	biological_process	positive regulation of cellular senescence
N	2000978	biological_process	negative regulation of forebrain neuron differentiation

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACRVKH

Chain	Residue	Details
B	TYR78-HIS84
A	TYR257-HIS263
L	TYR191-HIS197

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19349973, ECO:0000269|PubMed:7306483

Chain	Residue	Details
A	ASN86
M	ASN86

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site_id	SWS_FT_FI2
Number of Residues	2
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:7306483

Chain	Residue	Details
A	ASN176
M	ASN176

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