3CRL
Crystal structure of the PDHK2-L2 complex.
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004672 | molecular_function | protein kinase activity |
A | 0004674 | molecular_function | protein serine/threonine kinase activity |
A | 0004740 | molecular_function | pyruvate dehydrogenase (acetyl-transferring) kinase activity |
A | 0005515 | molecular_function | protein binding |
A | 0005524 | molecular_function | ATP binding |
A | 0005739 | cellular_component | mitochondrion |
A | 0005759 | cellular_component | mitochondrial matrix |
A | 0006111 | biological_process | regulation of gluconeogenesis |
A | 0006885 | biological_process | regulation of pH |
A | 0008286 | biological_process | insulin receptor signaling pathway |
A | 0010510 | biological_process | regulation of acetyl-CoA biosynthetic process from pyruvate |
A | 0010565 | biological_process | regulation of cellular ketone metabolic process |
A | 0010906 | biological_process | regulation of glucose metabolic process |
A | 0016301 | molecular_function | kinase activity |
A | 0018105 | biological_process | peptidyl-serine phosphorylation |
A | 0031670 | biological_process | cellular response to nutrient |
A | 0034614 | biological_process | cellular response to reactive oxygen species |
A | 0042593 | biological_process | glucose homeostasis |
A | 0042802 | molecular_function | identical protein binding |
A | 0042803 | molecular_function | protein homodimerization activity |
A | 0044877 | molecular_function | protein-containing complex binding |
A | 0045254 | cellular_component | pyruvate dehydrogenase complex |
A | 0050848 | biological_process | regulation of calcium-mediated signaling |
A | 0072332 | biological_process | intrinsic apoptotic signaling pathway by p53 class mediator |
B | 0004672 | molecular_function | protein kinase activity |
B | 0004674 | molecular_function | protein serine/threonine kinase activity |
B | 0004740 | molecular_function | pyruvate dehydrogenase (acetyl-transferring) kinase activity |
B | 0005515 | molecular_function | protein binding |
B | 0005524 | molecular_function | ATP binding |
B | 0005739 | cellular_component | mitochondrion |
B | 0005759 | cellular_component | mitochondrial matrix |
B | 0006111 | biological_process | regulation of gluconeogenesis |
B | 0006885 | biological_process | regulation of pH |
B | 0008286 | biological_process | insulin receptor signaling pathway |
B | 0010510 | biological_process | regulation of acetyl-CoA biosynthetic process from pyruvate |
B | 0010565 | biological_process | regulation of cellular ketone metabolic process |
B | 0010906 | biological_process | regulation of glucose metabolic process |
B | 0016301 | molecular_function | kinase activity |
B | 0018105 | biological_process | peptidyl-serine phosphorylation |
B | 0031670 | biological_process | cellular response to nutrient |
B | 0034614 | biological_process | cellular response to reactive oxygen species |
B | 0042593 | biological_process | glucose homeostasis |
B | 0042802 | molecular_function | identical protein binding |
B | 0042803 | molecular_function | protein homodimerization activity |
B | 0044877 | molecular_function | protein-containing complex binding |
B | 0045254 | cellular_component | pyruvate dehydrogenase complex |
B | 0050848 | biological_process | regulation of calcium-mediated signaling |
B | 0072332 | biological_process | intrinsic apoptotic signaling pathway by p53 class mediator |
C | 0006086 | biological_process | acetyl-CoA biosynthetic process from pyruvate |
C | 0045254 | cellular_component | pyruvate dehydrogenase complex |
D | 0006086 | biological_process | acetyl-CoA biosynthetic process from pyruvate |
D | 0045254 | cellular_component | pyruvate dehydrogenase complex |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 2 |
Details | BINDING SITE FOR RESIDUE MG A 2000 |
Chain | Residue |
A | GLU251 |
A | ASN255 |
site_id | AC2 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE MG B 2001 |
Chain | Residue |
B | ASN255 |
site_id | AC3 |
Number of Residues | 5 |
Details | BINDING SITE FOR RESIDUE K B 3001 |
Chain | Residue |
B | SER24 |
B | LYS25 |
B | PHE26 |
B | ASN63 |
B | TYR374 |
site_id | AC4 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE K A 3002 |
Chain | Residue |
A | PHE26 |
A | ASN63 |
A | TYR374 |
A | SER24 |
site_id | AC5 |
Number of Residues | 12 |
Details | BINDING SITE FOR RESIDUE ANP A 1000 |
Chain | Residue |
A | GLU251 |
A | ASN255 |
A | ARG258 |
A | ALA259 |
A | ASP290 |
A | LEU303 |
A | GLY325 |
A | PHE326 |
A | GLY327 |
A | TYR328 |
A | GLY329 |
A | LEU330 |
site_id | AC6 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE ANP B 1001 |
Chain | Residue |
B | GLU251 |
B | ASN255 |
B | ARG258 |
B | ALA259 |
B | ASP290 |
B | LEU303 |
B | LEU323 |
B | GLY325 |
B | PHE326 |
B | GLY327 |
B | TYR328 |
B | GLY329 |
B | LEU330 |
B | PRO331 |
Functional Information from PROSITE/UniProt
site_id | PS00178 |
Number of Residues | 12 |
Details | AA_TRNA_LIGASE_I Aminoacyl-transfer RNA synthetases class-I signature. PalSPtMTMGTV |
Chain | Residue | Details |
C | PRO138-VAL149 |
site_id | PS00189 |
Number of Residues | 30 |
Details | LIPOYL 2-oxo acid dehydrogenases acyltransferase component lipoyl binding site. GekLsegDLLaeIETdKATigFevqeeGyL |
Chain | Residue | Details |
C | GLY157-LEU186 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | MOD_RES: N6-lipoyllysine => ECO:0000255|PROSITE-ProRule:PRU01066, ECO:0000269|PubMed:15861126, ECO:0000269|PubMed:17532006, ECO:0000269|PubMed:17683942, ECO:0000269|PubMed:25525879, ECO:0007744|PDB:1Y8N, ECO:0007744|PDB:1Y8O, ECO:0007744|PDB:1Y8P, ECO:0007744|PDB:2PNR, ECO:0007744|PDB:2Q8I |
Chain | Residue | Details |
C | ILE206 | |
D | ILE206 | |
A | SER309 | |
A | GLY325 | |
B | GLU251 | |
B | ASP290 | |
B | SER309 | |
B | GLY325 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q15118 |
Chain | Residue | Details |
A | TYR215 | |
A | TYR216 | |
B | TYR215 | |
B | TYR216 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q8BFP9 |
Chain | Residue | Details |
A | LYS376 | |
B | LYS376 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1jm6 |
Chain | Residue | Details |
A | GLU251 | |
A | HIS247 |
site_id | CSA2 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1jm6 |
Chain | Residue | Details |
B | GLU251 | |
B | HIS247 |
site_id | MCSA1 |
Number of Residues | 4 |
Details | M-CSA 603 |
Chain | Residue | Details |
A | HIS247 | electrostatic stabiliser |
A | GLU251 | metal ligand, proton shuttle (general acid/base) |
A | LYS254 | metal ligand |
A | ASN255 | metal ligand |
site_id | MCSA2 |
Number of Residues | 4 |
Details | M-CSA 603 |
Chain | Residue | Details |
B | HIS247 | electrostatic stabiliser |
B | GLU251 | metal ligand, proton shuttle (general acid/base) |
B | LYS254 | metal ligand |
B | ASN255 | metal ligand |