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3CMV

Mechanism of homologous recombination from the RecA-ssDNA/dsDNA structures

Functional Information from GO Data
ChainGOidnamespacecontents
A0000725biological_processrecombinational repair
A0003677molecular_functionDNA binding
A0003684molecular_functiondamaged DNA binding
A0003697molecular_functionsingle-stranded DNA binding
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005737cellular_componentcytoplasm
A0006259biological_processDNA metabolic process
A0006281biological_processDNA repair
A0006310biological_processDNA recombination
A0006974biological_processDNA damage response
A0008094molecular_functionATP-dependent activity, acting on DNA
A0009355cellular_componentDNA polymerase V complex
A0009432biological_processSOS response
A0010212biological_processresponse to ionizing radiation
A0016887molecular_functionATP hydrolysis activity
A0019985biological_processtranslesion synthesis
A0035825biological_processhomologous recombination
A0048870biological_processcell motility
A0140297molecular_functionDNA-binding transcription factor binding
A0140664molecular_functionATP-dependent DNA damage sensor activity
B0000725biological_processrecombinational repair
B0003677molecular_functionDNA binding
B0003684molecular_functiondamaged DNA binding
B0003697molecular_functionsingle-stranded DNA binding
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005737cellular_componentcytoplasm
B0006259biological_processDNA metabolic process
B0006281biological_processDNA repair
B0006310biological_processDNA recombination
B0006974biological_processDNA damage response
B0008094molecular_functionATP-dependent activity, acting on DNA
B0009355cellular_componentDNA polymerase V complex
B0009432biological_processSOS response
B0010212biological_processresponse to ionizing radiation
B0016887molecular_functionATP hydrolysis activity
B0019985biological_processtranslesion synthesis
B0035825biological_processhomologous recombination
B0048870biological_processcell motility
B0140297molecular_functionDNA-binding transcription factor binding
B0140664molecular_functionATP-dependent DNA damage sensor activity
C0000725biological_processrecombinational repair
C0003677molecular_functionDNA binding
C0003684molecular_functiondamaged DNA binding
C0003697molecular_functionsingle-stranded DNA binding
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005737cellular_componentcytoplasm
C0006259biological_processDNA metabolic process
C0006281biological_processDNA repair
C0006310biological_processDNA recombination
C0006974biological_processDNA damage response
C0008094molecular_functionATP-dependent activity, acting on DNA
C0009355cellular_componentDNA polymerase V complex
C0009432biological_processSOS response
C0010212biological_processresponse to ionizing radiation
C0016887molecular_functionATP hydrolysis activity
C0019985biological_processtranslesion synthesis
C0035825biological_processhomologous recombination
C0048870biological_processcell motility
C0140297molecular_functionDNA-binding transcription factor binding
C0140664molecular_functionATP-dependent DNA damage sensor activity
D0000725biological_processrecombinational repair
D0003677molecular_functionDNA binding
D0003684molecular_functiondamaged DNA binding
D0003697molecular_functionsingle-stranded DNA binding
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005737cellular_componentcytoplasm
D0006259biological_processDNA metabolic process
D0006281biological_processDNA repair
D0006310biological_processDNA recombination
D0006974biological_processDNA damage response
D0008094molecular_functionATP-dependent activity, acting on DNA
D0009355cellular_componentDNA polymerase V complex
D0009432biological_processSOS response
D0010212biological_processresponse to ionizing radiation
D0016887molecular_functionATP hydrolysis activity
D0019985biological_processtranslesion synthesis
D0035825biological_processhomologous recombination
D0048870biological_processcell motility
D0140297molecular_functionDNA-binding transcription factor binding
D0140664molecular_functionATP-dependent DNA damage sensor activity
E0000725biological_processrecombinational repair
E0003677molecular_functionDNA binding
E0003684molecular_functiondamaged DNA binding
E0003697molecular_functionsingle-stranded DNA binding
E0005515molecular_functionprotein binding
E0005524molecular_functionATP binding
E0005737cellular_componentcytoplasm
E0006259biological_processDNA metabolic process
E0006281biological_processDNA repair
E0006310biological_processDNA recombination
E0006974biological_processDNA damage response
E0008094molecular_functionATP-dependent activity, acting on DNA
E0009355cellular_componentDNA polymerase V complex
E0009432biological_processSOS response
E0010212biological_processresponse to ionizing radiation
E0016887molecular_functionATP hydrolysis activity
E0019985biological_processtranslesion synthesis
E0035825biological_processhomologous recombination
E0048870biological_processcell motility
E0140297molecular_functionDNA-binding transcription factor binding
E0140664molecular_functionATP-dependent DNA damage sensor activity
F0000725biological_processrecombinational repair
F0003677molecular_functionDNA binding
F0003684molecular_functiondamaged DNA binding
F0003697molecular_functionsingle-stranded DNA binding
F0005515molecular_functionprotein binding
F0005524molecular_functionATP binding
F0005737cellular_componentcytoplasm
F0006259biological_processDNA metabolic process
F0006281biological_processDNA repair
F0006310biological_processDNA recombination
F0006974biological_processDNA damage response
F0008094molecular_functionATP-dependent activity, acting on DNA
F0009355cellular_componentDNA polymerase V complex
F0009432biological_processSOS response
F0010212biological_processresponse to ionizing radiation
F0016887molecular_functionATP hydrolysis activity
F0019985biological_processtranslesion synthesis
F0035825biological_processhomologous recombination
F0048870biological_processcell motility
F0140297molecular_functionDNA-binding transcription factor binding
F0140664molecular_functionATP-dependent DNA damage sensor activity
G0000725biological_processrecombinational repair
G0003677molecular_functionDNA binding
G0003684molecular_functiondamaged DNA binding
G0003697molecular_functionsingle-stranded DNA binding
G0005515molecular_functionprotein binding
G0005524molecular_functionATP binding
G0005737cellular_componentcytoplasm
G0006259biological_processDNA metabolic process
G0006281biological_processDNA repair
G0006310biological_processDNA recombination
G0006974biological_processDNA damage response
G0008094molecular_functionATP-dependent activity, acting on DNA
G0009355cellular_componentDNA polymerase V complex
G0009432biological_processSOS response
G0010212biological_processresponse to ionizing radiation
G0016887molecular_functionATP hydrolysis activity
G0019985biological_processtranslesion synthesis
G0035825biological_processhomologous recombination
G0048870biological_processcell motility
G0140297molecular_functionDNA-binding transcription factor binding
G0140664molecular_functionATP-dependent DNA damage sensor activity
H0000725biological_processrecombinational repair
H0003677molecular_functionDNA binding
H0003684molecular_functiondamaged DNA binding
H0003697molecular_functionsingle-stranded DNA binding
H0005515molecular_functionprotein binding
H0005524molecular_functionATP binding
H0005737cellular_componentcytoplasm
H0006259biological_processDNA metabolic process
H0006281biological_processDNA repair
H0006310biological_processDNA recombination
H0006974biological_processDNA damage response
H0008094molecular_functionATP-dependent activity, acting on DNA
H0009355cellular_componentDNA polymerase V complex
H0009432biological_processSOS response
H0010212biological_processresponse to ionizing radiation
H0016887molecular_functionATP hydrolysis activity
H0019985biological_processtranslesion synthesis
H0035825biological_processhomologous recombination
H0048870biological_processcell motility
H0140297molecular_functionDNA-binding transcription factor binding
H0140664molecular_functionATP-dependent DNA damage sensor activity
Functional Information from PDB Data
site_idAC1
Number of Residues3
DetailsBINDING SITE FOR RESIDUE MG A 701
ChainResidue
ATHR73
AALA98
AASP144

site_idAC2
Number of Residues3
DetailsBINDING SITE FOR RESIDUE MG A 1701
ChainResidue
ATHR1073
AALA1098
AASP1144

site_idAC3
Number of Residues3
DetailsBINDING SITE FOR RESIDUE MG A 2701
ChainResidue
ATHR2073
ALEU2099
AASP2144

site_idAC4
Number of Residues2
DetailsBINDING SITE FOR RESIDUE MG A 3701
ChainResidue
ATHR3073
AASP3144

site_idAC5
Number of Residues3
DetailsBINDING SITE FOR RESIDUE MG B 701
ChainResidue
BTHR73
BALA98
BASP144

site_idAC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE MG B 1701
ChainResidue
BTHR1073
BALA1098
BLEU1099
BASP1144

site_idAC7
Number of Residues4
DetailsBINDING SITE FOR RESIDUE MG B 2701
ChainResidue
BTHR2073
BALA2098
BLEU2099
BASP2144

site_idAC8
Number of Residues2
DetailsBINDING SITE FOR RESIDUE MG B 3701
ChainResidue
BTHR3073
BASP3144

site_idAC9
Number of Residues3
DetailsBINDING SITE FOR RESIDUE MG C 701
ChainResidue
CTHR73
CALA98
CASP144

site_idBC1
Number of Residues3
DetailsBINDING SITE FOR RESIDUE MG C 1701
ChainResidue
CTHR1073
CALA1098
CASP1144

site_idBC2
Number of Residues4
DetailsBINDING SITE FOR RESIDUE MG C 2701
ChainResidue
CTHR2073
CALA2098
CLEU2099
CASP2144

site_idBC3
Number of Residues2
DetailsBINDING SITE FOR RESIDUE MG C 3701
ChainResidue
CTHR3073
CASP3144

site_idBC4
Number of Residues3
DetailsBINDING SITE FOR RESIDUE MG D 701
ChainResidue
DTHR73
DALA98
DASP144

site_idBC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE MG D 1701
ChainResidue
DTHR1073
DALA1098
DLEU1099
DASP1144

site_idBC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE MG D 2701
ChainResidue
DTHR2073
DALA2098
DLEU2099
DASP2144

site_idBC7
Number of Residues2
DetailsBINDING SITE FOR RESIDUE MG D 3701
ChainResidue
DTHR3073
DASP3144

site_idBC8
Number of Residues3
DetailsBINDING SITE FOR RESIDUE MG E 701
ChainResidue
ETHR73
EALA98
EASP144

site_idBC9
Number of Residues4
DetailsBINDING SITE FOR RESIDUE MG E 1701
ChainResidue
ETHR1073
EALA1098
ELEU1099
EASP1144

site_idCC1
Number of Residues3
DetailsBINDING SITE FOR RESIDUE MG E 2701
ChainResidue
ETHR2073
ELEU2099
EASP2144

site_idCC2
Number of Residues2
DetailsBINDING SITE FOR RESIDUE MG E 3701
ChainResidue
ETHR3073
EASP3144

site_idCC3
Number of Residues2
DetailsBINDING SITE FOR RESIDUE MG F 701
ChainResidue
FTHR73
FASP144

site_idCC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE MG F 1701
ChainResidue
FTHR1073
FALA1098
FLEU1099
FASP1144

site_idCC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE MG F 2701
ChainResidue
FTHR2073
FALA2098
FLEU2099
FASP2144

site_idCC6
Number of Residues2
DetailsBINDING SITE FOR RESIDUE MG F 3701
ChainResidue
FTHR3073
FASP3144

site_idCC7
Number of Residues3
DetailsBINDING SITE FOR RESIDUE MG G 701
ChainResidue
GTHR73
GALA98
GASP144

site_idCC8
Number of Residues4
DetailsBINDING SITE FOR RESIDUE MG G 1701
ChainResidue
GTHR1073
GALA1098
GLEU1099
GASP1144

site_idCC9
Number of Residues4
DetailsBINDING SITE FOR RESIDUE MG G 2701
ChainResidue
GTHR2073
GALA2098
GLEU2099
GASP2144

site_idDC1
Number of Residues2
DetailsBINDING SITE FOR RESIDUE MG G 3701
ChainResidue
GTHR3073
GASP3144

site_idDC2
Number of Residues3
DetailsBINDING SITE FOR RESIDUE MG H 701
ChainResidue
HTHR73
HALA98
HASP144

site_idDC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE MG H 1701
ChainResidue
HTHR1073
HALA1098
HLEU1099
HASP1144

site_idDC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE MG H 2701
ChainResidue
HTHR2073
HALA2098
HLEU2099
HASP2144

site_idDC5
Number of Residues2
DetailsBINDING SITE FOR RESIDUE MG H 3701
ChainResidue
HTHR3073
HASP3144

site_idDC6
Number of Residues10
DetailsBINDING SITE FOR RESIDUE ANP A 400
ChainResidue
AGLU68
ASER69
ASER70
AGLY71
ALYS72
ATHR73
ATHR74
AASP100
ATYR103
ATYR264

site_idDC7
Number of Residues11
DetailsBINDING SITE FOR RESIDUE ANP A 1400
ChainResidue
AGLU1068
ASER1069
ASER1070
AGLY1071
ALYS1072
ATHR1073
ATHR1074
AASP1100
ATYR1103
ATYR1264
AGLY1265

site_idDC8
Number of Residues10
DetailsBINDING SITE FOR RESIDUE ANP A 2400
ChainResidue
AGLU2068
ASER2069
ASER2070
AGLY2071
ALYS2072
ATHR2073
ATHR2074
AGLU2096
AASP2100
ATYR2264

site_idDC9
Number of Residues11
DetailsBINDING SITE FOR RESIDUE ANP A 3400
ChainResidue
AGLU3068
ASER3069
AGLY3071
ALYS3072
ATHR3073
ATHR3074
AGLU3096
AASP3100
ATYR3103
AGLN3194
ATYR3264

site_idEC1
Number of Residues9
DetailsBINDING SITE FOR RESIDUE ANP B 400
ChainResidue
BGLU68
BSER69
BGLY71
BLYS72
BTHR73
BTHR74
BASP100
BTYR103
BTYR264

site_idEC2
Number of Residues9
DetailsBINDING SITE FOR RESIDUE ANP B 1400
ChainResidue
BGLU1068
BSER1069
BSER1070
BGLY1071
BLYS1072
BTHR1073
BTHR1074
BGLU1096
BASP1100

site_idEC3
Number of Residues10
DetailsBINDING SITE FOR RESIDUE ANP B 2400
ChainResidue
BGLU2068
BSER2069
BSER2070
BGLY2071
BLYS2072
BTHR2073
BTHR2074
BGLU2096
BASP2100
BTYR2264

site_idEC4
Number of Residues13
DetailsBINDING SITE FOR RESIDUE ANP B 3400
ChainResidue
BPRO3067
BGLU3068
BSER3069
BSER3070
BGLY3071
BLYS3072
BTHR3073
BTHR3074
BGLU3096
BASP3100
BTYR3103
BGLN3194
BTYR3264

site_idEC5
Number of Residues10
DetailsBINDING SITE FOR RESIDUE ANP C 400
ChainResidue
CGLU68
CSER69
CSER70
CGLY71
CLYS72
CTHR73
CTHR74
CGLU96
CASP100
CTYR103

site_idEC6
Number of Residues9
DetailsBINDING SITE FOR RESIDUE ANP C 1400
ChainResidue
CGLU1068
CSER1069
CSER1070
CGLY1071
CLYS1072
CTHR1073
CTHR1074
CGLU1096
CASP1100

site_idEC7
Number of Residues10
DetailsBINDING SITE FOR RESIDUE ANP C 2400
ChainResidue
CGLU2068
CSER2069
CSER2070
CGLY2071
CLYS2072
CTHR2073
CTHR2074
CGLU2096
CASP2100
CTYR2264

site_idEC8
Number of Residues10
DetailsBINDING SITE FOR RESIDUE ANP C 3400
ChainResidue
CSER3069
CGLY3071
CLYS3072
CTHR3073
CTHR3074
CGLU3096
CASP3100
CTYR3103
CGLN3194
CTYR3264

site_idEC9
Number of Residues10
DetailsBINDING SITE FOR RESIDUE ANP D 400
ChainResidue
DGLU68
DSER69
DSER70
DGLY71
DLYS72
DTHR73
DTHR74
DASP100
DSER240
DTYR264

site_idFC1
Number of Residues9
DetailsBINDING SITE FOR RESIDUE ANP D 1400
ChainResidue
DGLU1068
DSER1069
DSER1070
DGLY1071
DLYS1072
DTHR1073
DTHR1074
DGLU1096
DASP1100

site_idFC2
Number of Residues10
DetailsBINDING SITE FOR RESIDUE ANP D 2400
ChainResidue
DGLU2068
DSER2069
DSER2070
DGLY2071
DLYS2072
DTHR2073
DTHR2074
DGLU2096
DASP2100
DTYR2264

site_idFC3
Number of Residues13
DetailsBINDING SITE FOR RESIDUE ANP D 3400
ChainResidue
DPRO3067
DGLU3068
DSER3069
DSER3070
DGLY3071
DLYS3072
DTHR3073
DTHR3074
DGLU3096
DASP3100
DTYR3103
DGLN3194
DTYR3264

site_idFC4
Number of Residues8
DetailsBINDING SITE FOR RESIDUE ANP E 400
ChainResidue
EGLU68
ESER69
EGLY71
ELYS72
ETHR73
ETHR74
EGLU96
EASP100

site_idFC5
Number of Residues9
DetailsBINDING SITE FOR RESIDUE ANP E 1400
ChainResidue
ESER1069
ESER1070
EGLY1071
ELYS1072
ETHR1073
ETHR1074
EGLU1096
EASP1100
EGLY1265

site_idFC6
Number of Residues10
DetailsBINDING SITE FOR RESIDUE ANP E 2400
ChainResidue
EGLU2068
ESER2069
ESER2070
EGLY2071
ELYS2072
ETHR2073
ETHR2074
EGLU2096
EASP2100
ETYR2264

site_idFC7
Number of Residues13
DetailsBINDING SITE FOR RESIDUE ANP E 3400
ChainResidue
EPRO3067
EGLU3068
ESER3069
ESER3070
EGLY3071
ELYS3072
ETHR3073
ETHR3074
EGLU3096
EASP3100
ETYR3103
EGLN3194
ETYR3264

site_idFC8
Number of Residues9
DetailsBINDING SITE FOR RESIDUE ANP F 400
ChainResidue
FGLU68
FSER69
FSER70
FGLY71
FLYS72
FTHR73
FTHR74
FASP100
FTYR103

site_idFC9
Number of Residues8
DetailsBINDING SITE FOR RESIDUE ANP F 1400
ChainResidue
FSER1069
FSER1070
FGLY1071
FLYS1072
FTHR1073
FTHR1074
FGLU1096
FASP1100

site_idGC1
Number of Residues10
DetailsBINDING SITE FOR RESIDUE ANP F 2400
ChainResidue
FGLU2068
FSER2069
FSER2070
FGLY2071
FLYS2072
FTHR2073
FTHR2074
FGLU2096
FASP2100
FTYR2264

site_idGC2
Number of Residues13
DetailsBINDING SITE FOR RESIDUE ANP F 3400
ChainResidue
FPRO3067
FGLU3068
FSER3069
FSER3070
FGLY3071
FLYS3072
FTHR3073
FTHR3074
FGLU3096
FASP3100
FTYR3103
FGLN3194
FTYR3264

site_idGC3
Number of Residues12
DetailsBINDING SITE FOR RESIDUE ANP G 400
ChainResidue
GGLU68
GSER69
GSER70
GGLY71
GLYS72
GTHR73
GTHR74
GASP100
GTYR103
GSER240
GTYR264
GGLY265

site_idGC4
Number of Residues9
DetailsBINDING SITE FOR RESIDUE ANP G 1400
ChainResidue
GGLU1068
GSER1069
GSER1070
GGLY1071
GLYS1072
GTHR1073
GTHR1074
GGLU1096
GASP1100

site_idGC5
Number of Residues10
DetailsBINDING SITE FOR RESIDUE ANP G 2400
ChainResidue
GGLU2068
GSER2069
GSER2070
GGLY2071
GLYS2072
GTHR2073
GTHR2074
GGLU2096
GASP2100
GTYR2264

site_idGC6
Number of Residues11
DetailsBINDING SITE FOR RESIDUE ANP G 3400
ChainResidue
GGLU3068
GSER3069
GSER3070
GGLY3071
GLYS3072
GTHR3073
GTHR3074
GGLU3096
GASP3100
GTYR3103
GTYR3264

site_idGC7
Number of Residues10
DetailsBINDING SITE FOR RESIDUE ANP H 400
ChainResidue
HGLU68
HSER69
HSER70
HGLY71
HLYS72
HTHR73
HTHR74
HASP100
HTYR103
HTYR264

site_idGC8
Number of Residues10
DetailsBINDING SITE FOR RESIDUE ANP H 1400
ChainResidue
HGLU1068
HSER1069
HSER1070
HGLY1071
HLYS1072
HTHR1073
HTHR1074
HGLU1096
HASP1100
HGLY1265

site_idGC9
Number of Residues10
DetailsBINDING SITE FOR RESIDUE ANP H 2400
ChainResidue
HGLU2068
HSER2069
HSER2070
HGLY2071
HLYS2072
HTHR2073
HTHR2074
HGLU2096
HASP2100
HTYR2264

site_idHC1
Number of Residues12
DetailsBINDING SITE FOR RESIDUE ANP H 3400
ChainResidue
HPRO3067
HGLU3068
HSER3069
HSER3070
HGLY3071
HLYS3072
HTHR3073
HTHR3074
HGLU3096
HTYR3103
HGLN3194
HTYR3264

Functional Information from PROSITE/UniProt
site_idPS00321
Number of Residues9
DetailsRECA_1 recA signature. ALKFYASVR
ChainResidueDetails
AALA214-ARG222
AALA1214-ARG1222
AALA2214-ARG2222
AALA3214-ARG3222

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsBINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00268, ECO:0000269|PubMed:1731253
ChainResidueDetails
AGLY3066
BGLY3066
CGLY3066
DGLY3066
EGLY3066
FGLY3066
GGLY3066
HGLY3066

227111

PDB entries from 2024-11-06

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