3CL0
N1 Neuraminidase H274Y + oseltamivir
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004308 | molecular_function | exo-alpha-sialidase activity |
| A | 0005975 | biological_process | carbohydrate metabolic process |
| A | 0016020 | cellular_component | membrane |
| A | 0033644 | cellular_component | host cell membrane |
| A | 0046761 | biological_process | viral budding from plasma membrane |
| A | 0055036 | cellular_component | virion membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 1 |
| Chain | Residue |
| A | ASP293 |
| A | GLY297 |
| A | ASP324 |
| A | GLY345 |
| A | TYR347 |
| A | HOH972 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE G39 A 800 |
| Chain | Residue |
| A | ARG152 |
| A | GLU276 |
| A | ARG292 |
| A | ASN294 |
| A | TYR347 |
| A | ARG371 |
| A | TYR406 |
| A | HOH861 |
| A | HOH885 |
| A | ARG118 |
| A | GLU119 |
| A | ASP151 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_04071","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"HAMAP-Rule","id":"MF_04071","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 5 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_04071","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_04071","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"16915235","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18480754","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2HTY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CKZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CL0","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16915235","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18480754","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2HTY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CKZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CL0","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16915235","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18480754","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2HTY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3CKZ","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a4g |
| Chain | Residue | Details |
| A | ASP151 | |
| A | GLU277 |
