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3CHN

Solution structure of human secretory IgA1

Functional Information from GO Data
ChainGOidnamespacecontents
A0001895biological_processretina homeostasis
A0002250biological_processadaptive immune response
A0002376biological_processimmune system process
A0003094biological_processglomerular filtration
A0003823molecular_functionantigen binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005886cellular_componentplasma membrane
A0006955biological_processimmune response
A0016020cellular_componentmembrane
A0019731biological_processantibacterial humoral response
A0019814cellular_componentimmunoglobulin complex
A0034987molecular_functionimmunoglobulin receptor binding
A0050853biological_processB cell receptor signaling pathway
A0060267biological_processpositive regulation of respiratory burst
A0070062cellular_componentextracellular exosome
A0071735cellular_componentIgG immunoglobulin complex
A0071745cellular_componentIgA immunoglobulin complex
A0071748cellular_componentmonomeric IgA immunoglobulin complex
A0071751cellular_componentsecretory IgA immunoglobulin complex
A0071752cellular_componentsecretory dimeric IgA immunoglobulin complex
A0072562cellular_componentblood microparticle
B0001895biological_processretina homeostasis
B0002250biological_processadaptive immune response
B0002376biological_processimmune system process
B0003094biological_processglomerular filtration
B0003823molecular_functionantigen binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005886cellular_componentplasma membrane
B0006955biological_processimmune response
B0016020cellular_componentmembrane
B0019731biological_processantibacterial humoral response
B0019814cellular_componentimmunoglobulin complex
B0034987molecular_functionimmunoglobulin receptor binding
B0050853biological_processB cell receptor signaling pathway
B0060267biological_processpositive regulation of respiratory burst
B0070062cellular_componentextracellular exosome
B0071735cellular_componentIgG immunoglobulin complex
B0071745cellular_componentIgA immunoglobulin complex
B0071748cellular_componentmonomeric IgA immunoglobulin complex
B0071751cellular_componentsecretory IgA immunoglobulin complex
B0071752cellular_componentsecretory dimeric IgA immunoglobulin complex
B0072562cellular_componentblood microparticle
C0001895biological_processretina homeostasis
C0002250biological_processadaptive immune response
C0002376biological_processimmune system process
C0003094biological_processglomerular filtration
C0003823molecular_functionantigen binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005886cellular_componentplasma membrane
C0006955biological_processimmune response
C0016020cellular_componentmembrane
C0019731biological_processantibacterial humoral response
C0019814cellular_componentimmunoglobulin complex
C0034987molecular_functionimmunoglobulin receptor binding
C0050853biological_processB cell receptor signaling pathway
C0060267biological_processpositive regulation of respiratory burst
C0070062cellular_componentextracellular exosome
C0071735cellular_componentIgG immunoglobulin complex
C0071745cellular_componentIgA immunoglobulin complex
C0071748cellular_componentmonomeric IgA immunoglobulin complex
C0071751cellular_componentsecretory IgA immunoglobulin complex
C0071752cellular_componentsecretory dimeric IgA immunoglobulin complex
C0072562cellular_componentblood microparticle
D0001895biological_processretina homeostasis
D0002250biological_processadaptive immune response
D0002376biological_processimmune system process
D0003094biological_processglomerular filtration
D0003823molecular_functionantigen binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005886cellular_componentplasma membrane
D0006955biological_processimmune response
D0016020cellular_componentmembrane
D0019731biological_processantibacterial humoral response
D0019814cellular_componentimmunoglobulin complex
D0034987molecular_functionimmunoglobulin receptor binding
D0050853biological_processB cell receptor signaling pathway
D0060267biological_processpositive regulation of respiratory burst
D0070062cellular_componentextracellular exosome
D0071735cellular_componentIgG immunoglobulin complex
D0071745cellular_componentIgA immunoglobulin complex
D0071748cellular_componentmonomeric IgA immunoglobulin complex
D0071751cellular_componentsecretory IgA immunoglobulin complex
D0071752cellular_componentsecretory dimeric IgA immunoglobulin complex
D0072562cellular_componentblood microparticle
Functional Information from PROSITE/UniProt
site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH
ChainResidueDetails
LTYR192-HIS198
APHE433-HIS439

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:15084671, ECO:0000269|PubMed:16740002, ECO:0000269|PubMed:18780401, ECO:0000269|PubMed:6526384
ChainResidueDetails
SASN65
CSER227
CSER241
CSER243
ASER241
ASER243
BSER227
BSER241
BSER243
DSER227
DSER241
DSER243

site_idSWS_FT_FI2
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:15084671, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:16740002, ECO:0000269|PubMed:18780401, ECO:0000269|PubMed:6526384
ChainResidueDetails
SASN72
CTHR228
CTHR231
CTHR239
ATHR231
ATHR239
BTHR228
BTHR231
BTHR239
DTHR228
DTHR231
DTHR239

site_idSWS_FT_FI3
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:18780401, ECO:0000269|PubMed:6526384
ChainResidueDetails
SASN117
ASER235
BSER233
BSER235
DSER233
DSER235
CSER233
CSER235

site_idSWS_FT_FI4
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16740002, ECO:0000269|PubMed:18780401, ECO:0000269|PubMed:6526384
ChainResidueDetails
SASN168
SASN481
DTHR236
CTHR236

site_idSWS_FT_FI5
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:15084671, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:16740002, ECO:0000269|PubMed:18780401, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:6526384
ChainResidueDetails
SASN403
BASN266
DASN266
CASN266

site_idSWS_FT_FI6
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) (complex) asparagine => ECO:0000269|PubMed:15084671, ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:16740002, ECO:0000269|PubMed:18780401, ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:6526384
ChainResidueDetails
SASN451

218853

PDB entries from 2024-04-24

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