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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

3CHN

Solution structure of human secretory IgA1

Functional Information from GO Data
ChainGOidnamespacecontents
A0001895biological_processretina homeostasis
A0002250biological_processadaptive immune response
A0002376biological_processimmune system process
A0003094biological_processglomerular filtration
A0003823molecular_functionantigen binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005886cellular_componentplasma membrane
A0006955biological_processimmune response
A0016020cellular_componentmembrane
A0019731biological_processantibacterial humoral response
A0019814cellular_componentimmunoglobulin complex
A0034987molecular_functionimmunoglobulin receptor binding
A0050853biological_processB cell receptor signaling pathway
A0060267biological_processpositive regulation of respiratory burst
A0070062cellular_componentextracellular exosome
A0071735cellular_componentIgG immunoglobulin complex
A0071745cellular_componentIgA immunoglobulin complex
A0071748cellular_componentmonomeric IgA immunoglobulin complex
A0071751cellular_componentsecretory IgA immunoglobulin complex
A0071752cellular_componentsecretory dimeric IgA immunoglobulin complex
A0072562cellular_componentblood microparticle
B0001895biological_processretina homeostasis
B0002250biological_processadaptive immune response
B0002376biological_processimmune system process
B0003094biological_processglomerular filtration
B0003823molecular_functionantigen binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005886cellular_componentplasma membrane
B0006955biological_processimmune response
B0016020cellular_componentmembrane
B0019731biological_processantibacterial humoral response
B0019814cellular_componentimmunoglobulin complex
B0034987molecular_functionimmunoglobulin receptor binding
B0050853biological_processB cell receptor signaling pathway
B0060267biological_processpositive regulation of respiratory burst
B0070062cellular_componentextracellular exosome
B0071735cellular_componentIgG immunoglobulin complex
B0071745cellular_componentIgA immunoglobulin complex
B0071748cellular_componentmonomeric IgA immunoglobulin complex
B0071751cellular_componentsecretory IgA immunoglobulin complex
B0071752cellular_componentsecretory dimeric IgA immunoglobulin complex
B0072562cellular_componentblood microparticle
C0001895biological_processretina homeostasis
C0002250biological_processadaptive immune response
C0002376biological_processimmune system process
C0003094biological_processglomerular filtration
C0003823molecular_functionantigen binding
C0005576cellular_componentextracellular region
C0005615cellular_componentextracellular space
C0005886cellular_componentplasma membrane
C0006955biological_processimmune response
C0016020cellular_componentmembrane
C0019731biological_processantibacterial humoral response
C0019814cellular_componentimmunoglobulin complex
C0034987molecular_functionimmunoglobulin receptor binding
C0050853biological_processB cell receptor signaling pathway
C0060267biological_processpositive regulation of respiratory burst
C0070062cellular_componentextracellular exosome
C0071735cellular_componentIgG immunoglobulin complex
C0071745cellular_componentIgA immunoglobulin complex
C0071748cellular_componentmonomeric IgA immunoglobulin complex
C0071751cellular_componentsecretory IgA immunoglobulin complex
C0071752cellular_componentsecretory dimeric IgA immunoglobulin complex
C0072562cellular_componentblood microparticle
D0001895biological_processretina homeostasis
D0002250biological_processadaptive immune response
D0002376biological_processimmune system process
D0003094biological_processglomerular filtration
D0003823molecular_functionantigen binding
D0005576cellular_componentextracellular region
D0005615cellular_componentextracellular space
D0005886cellular_componentplasma membrane
D0006955biological_processimmune response
D0016020cellular_componentmembrane
D0019731biological_processantibacterial humoral response
D0019814cellular_componentimmunoglobulin complex
D0034987molecular_functionimmunoglobulin receptor binding
D0050853biological_processB cell receptor signaling pathway
D0060267biological_processpositive regulation of respiratory burst
D0070062cellular_componentextracellular exosome
D0071735cellular_componentIgG immunoglobulin complex
D0071745cellular_componentIgA immunoglobulin complex
D0071748cellular_componentmonomeric IgA immunoglobulin complex
D0071751cellular_componentsecretory IgA immunoglobulin complex
D0071752cellular_componentsecretory dimeric IgA immunoglobulin complex
D0072562cellular_componentblood microparticle
Functional Information from PROSITE/UniProt
site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH
ChainResidueDetails
LTYR192-HIS198
APHE433-HIS439
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues368
DetailsDomain: {"description":"Ig-like 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00114","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues380
DetailsDomain: {"description":"Ig-like 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00114","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues408
DetailsDomain: {"description":"Ig-like 3","evidences":[{"source":"PROSITE-ProRule","id":"PRU00114","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues104
DetailsRegion: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues72
DetailsCompositional bias: {"description":"Pro residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues12
DetailsGlycosylation: {"description":"O-linked (GalNAc...) serine","evidences":[{"source":"PubMed","id":"4373463","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues12
DetailsGlycosylation: {"description":"O-linked (GalNAc...) threonine","evidences":[{"source":"PubMed","id":"20823119","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31959827","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues8
DetailsGlycosylation: {"description":"O-linked (GalNAc...) serine","evidences":[{"source":"PubMed","id":"20823119","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31959827","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"4373463","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues4
DetailsGlycosylation: {"description":"O-linked (GalNAc...) threonine","evidences":[{"source":"PubMed","id":"31959827","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues4
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"15084671","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19139490","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19838169","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22171320","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues188
DetailsDomain: {"description":"Ig-like V-type 4"}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"15084671","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16740002","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18780401","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"6526384","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues101
DetailsDomain: {"description":"Ig-like V-type 1; required for binding to polymeric IgA and IgM","evidences":[{"source":"PubMed","id":"10229845","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15530357","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues92
DetailsDomain: {"description":"Ig-like V-type 2"}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues102
DetailsDomain: {"description":"Ig-like V-type 3"}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues99
DetailsDomain: {"description":"Ig-like V-type 5"}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"15084671","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16740002","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18780401","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"6526384","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"15084671","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16740002","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18780401","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"6526384","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI19
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"18780401","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"6526384","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI20
Number of Residues2
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16740002","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18780401","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"6526384","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI21
Number of Residues1
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) (complex) asparagine","evidences":[{"source":"PubMed","id":"15084671","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16740002","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18780401","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19139490","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"6526384","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

246333

PDB entries from 2025-12-17

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