3CH5
The crystal structure of the RanGDP-Nup153ZnF2 complex
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000054 | biological_process | ribosomal subunit export from nucleus |
A | 0000055 | biological_process | ribosomal large subunit export from nucleus |
A | 0000056 | biological_process | ribosomal small subunit export from nucleus |
A | 0000070 | biological_process | mitotic sister chromatid segregation |
A | 0000278 | biological_process | mitotic cell cycle |
A | 0000287 | molecular_function | magnesium ion binding |
A | 0000785 | cellular_component | chromatin |
A | 0001673 | cellular_component | male germ cell nucleus |
A | 0002177 | cellular_component | manchette |
A | 0003682 | molecular_function | chromatin binding |
A | 0003723 | molecular_function | RNA binding |
A | 0003924 | molecular_function | GTPase activity |
A | 0003925 | molecular_function | G protein activity |
A | 0005049 | molecular_function | nuclear export signal receptor activity |
A | 0005515 | molecular_function | protein binding |
A | 0005525 | molecular_function | GTP binding |
A | 0005634 | cellular_component | nucleus |
A | 0005635 | cellular_component | nuclear envelope |
A | 0005643 | cellular_component | nuclear pore |
A | 0005654 | cellular_component | nucleoplasm |
A | 0005730 | cellular_component | nucleolus |
A | 0005737 | cellular_component | cytoplasm |
A | 0005814 | cellular_component | centriole |
A | 0005829 | cellular_component | cytosol |
A | 0006259 | biological_process | DNA metabolic process |
A | 0006606 | biological_process | protein import into nucleus |
A | 0006611 | biological_process | protein export from nucleus |
A | 0006913 | biological_process | nucleocytoplasmic transport |
A | 0007052 | biological_process | mitotic spindle organization |
A | 0007286 | biological_process | spermatid development |
A | 0008104 | biological_process | protein localization |
A | 0014070 | biological_process | response to organic cyclic compound |
A | 0015031 | biological_process | protein transport |
A | 0016020 | cellular_component | membrane |
A | 0016032 | biological_process | viral process |
A | 0016787 | molecular_function | hydrolase activity |
A | 0019003 | molecular_function | GDP binding |
A | 0019904 | molecular_function | protein domain specific binding |
A | 0021766 | biological_process | hippocampus development |
A | 0030036 | biological_process | actin cytoskeleton organization |
A | 0030496 | cellular_component | midbody |
A | 0031503 | biological_process | protein-containing complex localization |
A | 0032092 | biological_process | positive regulation of protein binding |
A | 0032991 | cellular_component | protein-containing complex |
A | 0035281 | biological_process | pre-miRNA export from nucleus |
A | 0036126 | cellular_component | sperm flagellum |
A | 0042307 | biological_process | positive regulation of protein import into nucleus |
A | 0042470 | cellular_component | melanosome |
A | 0042565 | cellular_component | RNA nuclear export complex |
A | 0044877 | molecular_function | protein-containing complex binding |
A | 0045296 | molecular_function | cadherin binding |
A | 0045505 | molecular_function | dynein intermediate chain binding |
A | 0046039 | biological_process | GTP metabolic process |
A | 0046872 | molecular_function | metal ion binding |
A | 0046982 | molecular_function | protein heterodimerization activity |
A | 0051301 | biological_process | cell division |
A | 0055037 | cellular_component | recycling endosome |
A | 0061015 | biological_process | snRNA import into nucleus |
A | 0061676 | molecular_function | importin-alpha family protein binding |
A | 0070062 | cellular_component | extracellular exosome |
A | 0070883 | molecular_function | pre-miRNA binding |
A | 0071389 | biological_process | cellular response to mineralocorticoid stimulus |
A | 0090543 | cellular_component | Flemming body |
A | 1902570 | biological_process | protein localization to nucleolus |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 1 |
Details | BINDING SITE FOR RESIDUE MG A 221 |
Chain | Residue |
A | THR24 |
site_id | AC2 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE ZN B 800 |
Chain | Residue |
B | CYS727 |
B | CYS730 |
B | CYS741 |
B | CYS744 |
site_id | AC3 |
Number of Residues | 4 |
Details | BINDING SITE FOR RESIDUE SO4 A 222 |
Chain | Residue |
A | THR32 |
A | HIS53 |
A | PRO180 |
A | ALA181 |
site_id | AC4 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE GDP A 220 |
Chain | Residue |
A | ASP18 |
A | GLY19 |
A | GLY20 |
A | THR21 |
A | GLY22 |
A | LYS23 |
A | THR24 |
A | THR25 |
A | ASN122 |
A | LYS123 |
A | ASP125 |
A | ILE126 |
A | SER150 |
A | ALA151 |
A | LYS152 |
Functional Information from PROSITE/UniProt
site_id | PS01358 |
Number of Residues | 20 |
Details | ZF_RANBP2_1 Zinc finger RanBP2-type signature. WdCdt..ClvqNkpeavkCvaC |
Chain | Residue | Details |
B | TRP725-CYS744 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 29 |
Details | ZN_FING: RanBP2-type 2 => ECO:0000255|PROSITE-ProRule:PRU00322 |
Chain | Residue | Details |
B | ALA721-GLY750 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | BINDING: BINDING => ECO:0000269|PubMed:18611384, ECO:0000269|PubMed:19505478 |
Chain | Residue | Details |
B | CYS727 | |
B | CYS730 | |
B | CYS741 | |
B | CYS744 |
site_id | SWS_FT_FI3 |
Number of Residues | 1 |
Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P49790 |
Chain | Residue | Details |
B | LYS717 |
Chain | Residue | Details |
A | ASN122 |
Chain | Residue | Details |
A | SER150 |
site_id | SWS_FT_FI6 |
Number of Residues | 1 |
Details | SITE: Essential for GTP hydrolysis => ECO:0000269|PubMed:18591255, ECO:0000269|PubMed:26272610, ECO:0000269|PubMed:8636225 |
Chain | Residue | Details |
A | GLN69 |
site_id | SWS_FT_FI7 |
Number of Residues | 1 |
Details | MOD_RES: N-acetylalanine => ECO:0000269|Ref.12, ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895, ECO:0007744|PubMed:22814378 |
Chain | Residue | Details |
A | ALA2 |
site_id | SWS_FT_FI8 |
Number of Residues | 1 |
Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
A | THR24 |
site_id | SWS_FT_FI9 |
Number of Residues | 1 |
Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:31075303 |
Chain | Residue | Details |
A | LYS37 |
site_id | SWS_FT_FI10 |
Number of Residues | 2 |
Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
Chain | Residue | Details |
A | LYS60 | |
A | LYS99 |
site_id | SWS_FT_FI11 |
Number of Residues | 1 |
Details | MOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861 |
Chain | Residue | Details |
A | LYS71 |
site_id | SWS_FT_FI12 |
Number of Residues | 1 |
Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:29040603 |
Chain | Residue | Details |
A | LYS134 |
site_id | SWS_FT_FI13 |
Number of Residues | 1 |
Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P62827 |
Chain | Residue | Details |
A | LYS159 |
site_id | SWS_FT_FI14 |
Number of Residues | 1 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate |
Chain | Residue | Details |
A | LYS71 |
site_id | SWS_FT_FI15 |
Number of Residues | 2 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
Chain | Residue | Details |
A | LYS152 |