3CH4
The Crystal Structure of Human Phosphomavelonate Kinase At 1.8 A Resolution
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| B | 0000166 | molecular_function | nucleotide binding |
| B | 0004631 | molecular_function | phosphomevalonate kinase activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005524 | molecular_function | ATP binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005777 | cellular_component | peroxisome |
| B | 0005829 | cellular_component | cytosol |
| B | 0006629 | biological_process | lipid metabolic process |
| B | 0006694 | biological_process | steroid biosynthetic process |
| B | 0006695 | biological_process | cholesterol biosynthetic process |
| B | 0008202 | biological_process | steroid metabolic process |
| B | 0008203 | biological_process | cholesterol metabolic process |
| B | 0010142 | biological_process | farnesyl diphosphate biosynthetic process, mevalonate pathway |
| B | 0016020 | cellular_component | membrane |
| B | 0016126 | biological_process | sterol biosynthetic process |
| B | 0016301 | molecular_function | kinase activity |
| B | 0016740 | molecular_function | transferase activity |
| B | 0019287 | biological_process | isopentenyl diphosphate biosynthetic process, mevalonate pathway |
| B | 0033386 | biological_process | geranylgeranyl diphosphate biosynthetic process |
| B | 0033489 | biological_process | cholesterol biosynthetic process via desmosterol |
| B | 0033490 | biological_process | cholesterol biosynthetic process via lathosterol |
| B | 0036197 | biological_process | zymosterol biosynthetic process |
| B | 0070062 | cellular_component | extracellular exosome |
| B | 0070723 | biological_process | response to cholesterol |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE SO4 B 201 |
| Chain | Residue |
| B | LYS19 |
| B | HOH207 |
| B | HOH229 |
| B | HOH247 |
| B | SER20 |
| B | GLY21 |
| B | LYS22 |
| B | ASP23 |
| B | PHE24 |
| B | ARG141 |
| B | GLU169 |
| B | HIS171 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 B 202 |
| Chain | Residue |
| B | LYS19 |
| B | ARG141 |
| B | HIS171 |
| B | ARG176 |
| B | GLN180 |
| B | HOH253 |
| B | HOH285 |
| B | HOH326 |
| B | HOH330 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MPD B 203 |
| Chain | Residue |
| B | ASN170 |
| B | GLY172 |
| B | GLU174 |
| B | HOH236 |
| B | HOH252 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MPD B 204 |
| Chain | Residue |
| B | GLN140 |
| B | GLY142 |
| B | TRP166 |
| B | ILE168 |
| B | ASN183 |
| B | HOH285 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"16519518","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"18618710","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"17902708","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"18618710","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"18618710","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"18618710","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
