Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3CH1

Crystal structure of H-2Db in complex with chimeric gp100

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0001913	biological_process	T cell mediated cytotoxicity
B	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
B	0002237	biological_process	response to molecule of bacterial origin
B	0002376	biological_process	immune system process
B	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
B	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
B	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
B	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
B	0002726	biological_process	positive regulation of T cell cytokine production
B	0005198	molecular_function	structural molecule activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005765	cellular_component	lysosomal membrane
B	0005794	cellular_component	Golgi apparatus
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006826	biological_process	iron ion transport
B	0006879	biological_process	intracellular iron ion homeostasis
B	0006955	biological_process	immune response
B	0006968	biological_process	cellular defense response
B	0007608	biological_process	sensory perception of smell
B	0007611	biological_process	learning or memory
B	0009897	cellular_component	external side of plasma membrane
B	0010038	biological_process	response to metal ion
B	0010977	biological_process	negative regulation of neuron projection development
B	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
B	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
B	0023026	molecular_function	MHC class II protein complex binding
B	0030670	cellular_component	phagocytic vesicle membrane
B	0031902	cellular_component	late endosome membrane
B	0033077	biological_process	T cell differentiation in thymus
B	0033572	biological_process	transferrin transport
B	0034756	biological_process	regulation of iron ion transport
B	0034757	biological_process	negative regulation of iron ion transport
B	0042026	biological_process	protein refolding
B	0042605	molecular_function	peptide antigen binding
B	0042612	cellular_component	MHC class I protein complex
B	0042613	cellular_component	MHC class II protein complex
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0042824	cellular_component	MHC class I peptide loading complex
B	0045646	biological_process	regulation of erythrocyte differentiation
B	0048260	biological_process	positive regulation of receptor-mediated endocytosis
B	0048261	biological_process	negative regulation of receptor-mediated endocytosis
B	0050680	biological_process	negative regulation of epithelial cell proliferation
B	0050768	biological_process	negative regulation of neurogenesis
B	0050778	biological_process	positive regulation of immune response
B	0050870	biological_process	positive regulation of T cell activation
B	0051289	biological_process	protein homotetramerization
B	0060586	biological_process	multicellular organismal-level iron ion homeostasis
B	0071281	biological_process	cellular response to iron ion
B	0071283	biological_process	cellular response to iron(III) ion
B	0071316	biological_process	cellular response to nicotine
B	1990000	biological_process	amyloid fibril formation
B	1990712	cellular_component	HFE-transferrin receptor complex
B	2000774	biological_process	positive regulation of cellular senescence
B	2000978	biological_process	negative regulation of forebrain neuron differentiation
E	0001913	biological_process	T cell mediated cytotoxicity
E	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
E	0002237	biological_process	response to molecule of bacterial origin
E	0002376	biological_process	immune system process
E	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
E	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
E	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
E	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
E	0002726	biological_process	positive regulation of T cell cytokine production
E	0005198	molecular_function	structural molecule activity
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0005765	cellular_component	lysosomal membrane
E	0005794	cellular_component	Golgi apparatus
E	0005829	cellular_component	cytosol
E	0005886	cellular_component	plasma membrane
E	0006826	biological_process	iron ion transport
E	0006879	biological_process	intracellular iron ion homeostasis
E	0006955	biological_process	immune response
E	0006968	biological_process	cellular defense response
E	0007608	biological_process	sensory perception of smell
E	0007611	biological_process	learning or memory
E	0009897	cellular_component	external side of plasma membrane
E	0010038	biological_process	response to metal ion
E	0010977	biological_process	negative regulation of neuron projection development
E	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
E	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
E	0023026	molecular_function	MHC class II protein complex binding
E	0030670	cellular_component	phagocytic vesicle membrane
E	0031902	cellular_component	late endosome membrane
E	0033077	biological_process	T cell differentiation in thymus
E	0033572	biological_process	transferrin transport
E	0034756	biological_process	regulation of iron ion transport
E	0034757	biological_process	negative regulation of iron ion transport
E	0042026	biological_process	protein refolding
E	0042605	molecular_function	peptide antigen binding
E	0042612	cellular_component	MHC class I protein complex
E	0042613	cellular_component	MHC class II protein complex
E	0042802	molecular_function	identical protein binding
E	0042803	molecular_function	protein homodimerization activity
E	0042824	cellular_component	MHC class I peptide loading complex
E	0045646	biological_process	regulation of erythrocyte differentiation
E	0048260	biological_process	positive regulation of receptor-mediated endocytosis
E	0048261	biological_process	negative regulation of receptor-mediated endocytosis
E	0050680	biological_process	negative regulation of epithelial cell proliferation
E	0050768	biological_process	negative regulation of neurogenesis
E	0050778	biological_process	positive regulation of immune response
E	0050870	biological_process	positive regulation of T cell activation
E	0051289	biological_process	protein homotetramerization
E	0060586	biological_process	multicellular organismal-level iron ion homeostasis
E	0071281	biological_process	cellular response to iron ion
E	0071283	biological_process	cellular response to iron(III) ion
E	0071316	biological_process	cellular response to nicotine
E	1990000	biological_process	amyloid fibril formation
E	1990712	cellular_component	HFE-transferrin receptor complex
E	2000774	biological_process	positive regulation of cellular senescence
E	2000978	biological_process	negative regulation of forebrain neuron differentiation
H	0001913	biological_process	T cell mediated cytotoxicity
H	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
H	0002237	biological_process	response to molecule of bacterial origin
H	0002376	biological_process	immune system process
H	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
H	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
H	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
H	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
H	0002726	biological_process	positive regulation of T cell cytokine production
H	0005198	molecular_function	structural molecule activity
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005615	cellular_component	extracellular space
H	0005765	cellular_component	lysosomal membrane
H	0005794	cellular_component	Golgi apparatus
H	0005829	cellular_component	cytosol
H	0005886	cellular_component	plasma membrane
H	0006826	biological_process	iron ion transport
H	0006879	biological_process	intracellular iron ion homeostasis
H	0006955	biological_process	immune response
H	0006968	biological_process	cellular defense response
H	0007608	biological_process	sensory perception of smell
H	0007611	biological_process	learning or memory
H	0009897	cellular_component	external side of plasma membrane
H	0010038	biological_process	response to metal ion
H	0010977	biological_process	negative regulation of neuron projection development
H	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
H	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
H	0023026	molecular_function	MHC class II protein complex binding
H	0030670	cellular_component	phagocytic vesicle membrane
H	0031902	cellular_component	late endosome membrane
H	0033077	biological_process	T cell differentiation in thymus
H	0033572	biological_process	transferrin transport
H	0034756	biological_process	regulation of iron ion transport
H	0034757	biological_process	negative regulation of iron ion transport
H	0042026	biological_process	protein refolding
H	0042605	molecular_function	peptide antigen binding
H	0042612	cellular_component	MHC class I protein complex
H	0042613	cellular_component	MHC class II protein complex
H	0042802	molecular_function	identical protein binding
H	0042803	molecular_function	protein homodimerization activity
H	0042824	cellular_component	MHC class I peptide loading complex
H	0045646	biological_process	regulation of erythrocyte differentiation
H	0048260	biological_process	positive regulation of receptor-mediated endocytosis
H	0048261	biological_process	negative regulation of receptor-mediated endocytosis
H	0050680	biological_process	negative regulation of epithelial cell proliferation
H	0050768	biological_process	negative regulation of neurogenesis
H	0050778	biological_process	positive regulation of immune response
H	0050870	biological_process	positive regulation of T cell activation
H	0051289	biological_process	protein homotetramerization
H	0060586	biological_process	multicellular organismal-level iron ion homeostasis
H	0071281	biological_process	cellular response to iron ion
H	0071283	biological_process	cellular response to iron(III) ion
H	0071316	biological_process	cellular response to nicotine
H	1990000	biological_process	amyloid fibril formation
H	1990712	cellular_component	HFE-transferrin receptor complex
H	2000774	biological_process	positive regulation of cellular senescence
H	2000978	biological_process	negative regulation of forebrain neuron differentiation
K	0001913	biological_process	T cell mediated cytotoxicity
K	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
K	0002237	biological_process	response to molecule of bacterial origin
K	0002376	biological_process	immune system process
K	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
K	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
K	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
K	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
K	0002726	biological_process	positive regulation of T cell cytokine production
K	0005198	molecular_function	structural molecule activity
K	0005515	molecular_function	protein binding
K	0005576	cellular_component	extracellular region
K	0005615	cellular_component	extracellular space
K	0005765	cellular_component	lysosomal membrane
K	0005794	cellular_component	Golgi apparatus
K	0005829	cellular_component	cytosol
K	0005886	cellular_component	plasma membrane
K	0006826	biological_process	iron ion transport
K	0006879	biological_process	intracellular iron ion homeostasis
K	0006955	biological_process	immune response
K	0006968	biological_process	cellular defense response
K	0007608	biological_process	sensory perception of smell
K	0007611	biological_process	learning or memory
K	0009897	cellular_component	external side of plasma membrane
K	0010038	biological_process	response to metal ion
K	0010977	biological_process	negative regulation of neuron projection development
K	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
K	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
K	0023026	molecular_function	MHC class II protein complex binding
K	0030670	cellular_component	phagocytic vesicle membrane
K	0031902	cellular_component	late endosome membrane
K	0033077	biological_process	T cell differentiation in thymus
K	0033572	biological_process	transferrin transport
K	0034756	biological_process	regulation of iron ion transport
K	0034757	biological_process	negative regulation of iron ion transport
K	0042026	biological_process	protein refolding
K	0042605	molecular_function	peptide antigen binding
K	0042612	cellular_component	MHC class I protein complex
K	0042613	cellular_component	MHC class II protein complex
K	0042802	molecular_function	identical protein binding
K	0042803	molecular_function	protein homodimerization activity
K	0042824	cellular_component	MHC class I peptide loading complex
K	0045646	biological_process	regulation of erythrocyte differentiation
K	0048260	biological_process	positive regulation of receptor-mediated endocytosis
K	0048261	biological_process	negative regulation of receptor-mediated endocytosis
K	0050680	biological_process	negative regulation of epithelial cell proliferation
K	0050768	biological_process	negative regulation of neurogenesis
K	0050778	biological_process	positive regulation of immune response
K	0050870	biological_process	positive regulation of T cell activation
K	0051289	biological_process	protein homotetramerization
K	0060586	biological_process	multicellular organismal-level iron ion homeostasis
K	0071281	biological_process	cellular response to iron ion
K	0071283	biological_process	cellular response to iron(III) ion
K	0071316	biological_process	cellular response to nicotine
K	1990000	biological_process	amyloid fibril formation
K	1990712	cellular_component	HFE-transferrin receptor complex
K	2000774	biological_process	positive regulation of cellular senescence
K	2000978	biological_process	negative regulation of forebrain neuron differentiation

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL A 278

Chain	Residue
A	GLU166
A	ARG170

site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL A 279

Chain	Residue
B	SER55
B	PHE56
A	PHE8
A	GLU9
A	THR10
A	ILE23
A	VAL25
A	TYR27
B	MET54

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 280

Chain	Residue
A	ARG111
A	GLY112
A	TYR113
A	LEU114
A	GLN115
A	LEU126
A	GLU128

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL A 281

Chain	Residue
A	PRO185
A	ALA187
A	LEU270

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 282

Chain	Residue
A	ARG6
A	PHE8
A	TYR27
A	ASN30
A	HOH315
A	HOH340

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL A 283

Chain	Residue
A	GLU19
A	ARG75
A	HOH319

site_id	AC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE GOL A 284

Chain	Residue
A	TRP204
A	ARG234
A	GLN242
B	SER11
B	PRO14
B	PRO15
B	ARG97

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 277

Chain	Residue
A	PRO15
A	GLY16
A	ALA89
A	GLY90

site_id	AC9
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL B 100

Chain	Residue
B	GLN8
B	VAL9
B	VAL93
B	TYR94
B	ASP96
B	MET99
B	HOH131
B	HOH142

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL B 101

Chain	Residue
A	ARG121
B	ILE1
B	GLN2
B	LYS3
B	HOH149

site_id	BC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL D 278

Chain	Residue
D	GLU166
D	TRP167
D	ARG170

site_id	BC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL D 279

Chain	Residue
D	ARG6
D	TYR27
D	ASN30
D	HOH305
D	HOH309

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 D 277

Chain	Residue
D	PRO15
D	GLY16
D	ALA89
D	GLY90

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL E 100

Chain	Residue
E	HIS13
E	PRO20
E	ASN21
E	ILE22
E	GLU69

site_id	BC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL E 101

Chain	Residue
D	TRP204
D	ARG234
D	GLN242
E	SER11
E	PRO14
E	PRO15
E	ARG97
E	MET99
E	HOH118

site_id	BC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL E 102

Chain	Residue
E	LYS41
E	ASN42
E	LYS44

site_id	BC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL E 103

Chain	Residue
D	ARG121
D	HOH340
E	ILE1
E	GLN2
E	LYS3

site_id	BC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE GOL E 104

Chain	Residue
E	ILE1
E	GLN2

site_id	CC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL G 277

Chain	Residue
G	ARG6
G	TYR27
G	ASN30
G	HOH333
G	HOH369

site_id	CC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL G 278

Chain	Residue
H	PRO33
H	HIS34
G	VAL12
G	ARG14
G	SER92
H	PRO32

site_id	CC3
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL J 280

Chain	Residue
J	ARG6
J	TYR27
J	ASN30
J	HOH292
J	HOH313

site_id	CC4
Number of Residues	8
Details	BINDING SITE FOR RESIDUE GOL J 281

Chain	Residue
J	VAL12
J	ARG14
J	SER92
J	HOH330
J	HOH363
K	PRO32
K	PRO33
K	HIS34

site_id	CC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL J 282

Chain	Residue
J	TYR84
J	ILE142
J	LYS146
J	HOH326
J	HOH349

site_id	CC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL J 283

Chain	Residue
J	GLU19
J	PRO20
J	GLU71
J	GLN72
J	ARG75

site_id	CC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE GOL J 284

Chain	Residue
J	GLU166
J	TRP167
J	ARG170

site_id	CC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL J 285

Chain	Residue
J	ARG21
J	HOH363
K	MET54
K	HOH126

site_id	CC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 J 277

Chain	Residue
J	PRO15
J	GLY16
J	ALA89
J	GLY90

site_id	DC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 J 278

Chain	Residue
J	GLU58
J	TYR59
J	ARG62
J	TRP167
L	GLU1

site_id	DC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 J 279

Chain	Residue
J	ARG75
J	ARG79
J	HOH351

site_id	DC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL I 10

Chain	Residue
G	TRP73
I	GLN6
I	TRP8
I	HOH43
I	HOH327
I	HOH333

site_id	DC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL I 16

Chain	Residue
G	VAL76
I	TRP8
I	HOH476
I	HOH494

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCRVYH

Chain	Residue	Details
A	TYR257-HIS263
B	TYR78-HIS84

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:3980466, ECO:0000269\|PubMed:7118212

Chain	Residue	Details
A	ASN86
D	ASN86
G	ASN86
J	ASN86

site_id	SWS_FT_FI2
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000305

Chain	Residue	Details
A	ASN176
D	ASN176
G	ASN176
J	ASN176

site_id	SWS_FT_FI3
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:3980466

Chain	Residue	Details
A	ASN256
D	ASN256
G	ASN256
J	ASN256

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)