3CFV

Structural basis of the interaction of RbAp46/RbAp48 with histone H4

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000118	cellular_component	histone deacetylase complex
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0000781	cellular_component	chromosome, telomeric region
A	0003723	molecular_function	RNA binding
A	0005515	molecular_function	protein binding
A	0005634	cellular_component	nucleus
A	0005654	cellular_component	nucleoplasm
A	0005829	cellular_component	cytosol
A	0006260	biological_process	DNA replication
A	0006325	biological_process	chromatin organization
A	0006338	biological_process	chromatin remodeling
A	0006355	biological_process	regulation of DNA-templated transcription
A	0007420	biological_process	brain development
A	0016581	cellular_component	NuRD complex
A	0016589	cellular_component	NURF complex
A	0030308	biological_process	negative regulation of cell growth
A	0030336	biological_process	negative regulation of cell migration
A	0030512	biological_process	negative regulation of transforming growth factor beta receptor signaling pathway
A	0035098	cellular_component	ESC/E(Z) complex
A	0042393	molecular_function	histone binding
A	0042659	biological_process	regulation of cell fate specification
A	0045892	biological_process	negative regulation of DNA-templated transcription
A	0045893	biological_process	positive regulation of DNA-templated transcription
A	0048545	biological_process	response to steroid hormone
A	0070370	biological_process	cellular heat acclimation
A	0070822	cellular_component	Sin3-type complex
A	1902455	biological_process	negative regulation of stem cell population maintenance
A	1902459	biological_process	positive regulation of stem cell population maintenance
A	1904949	cellular_component	ATPase complex
A	2000736	biological_process	regulation of stem cell differentiation
B	0000118	cellular_component	histone deacetylase complex
B	0000122	biological_process	negative regulation of transcription by RNA polymerase II
B	0000781	cellular_component	chromosome, telomeric region
B	0003723	molecular_function	RNA binding
B	0005515	molecular_function	protein binding
B	0005634	cellular_component	nucleus
B	0005654	cellular_component	nucleoplasm
B	0005829	cellular_component	cytosol
B	0006260	biological_process	DNA replication
B	0006325	biological_process	chromatin organization
B	0006338	biological_process	chromatin remodeling
B	0006355	biological_process	regulation of DNA-templated transcription
B	0007420	biological_process	brain development
B	0016581	cellular_component	NuRD complex
B	0016589	cellular_component	NURF complex
B	0030308	biological_process	negative regulation of cell growth
B	0030336	biological_process	negative regulation of cell migration
B	0030512	biological_process	negative regulation of transforming growth factor beta receptor signaling pathway
B	0035098	cellular_component	ESC/E(Z) complex
B	0042393	molecular_function	histone binding
B	0042659	biological_process	regulation of cell fate specification
B	0045892	biological_process	negative regulation of DNA-templated transcription
B	0045893	biological_process	positive regulation of DNA-templated transcription
B	0048545	biological_process	response to steroid hormone
B	0070370	biological_process	cellular heat acclimation
B	0070822	cellular_component	Sin3-type complex
B	1902455	biological_process	negative regulation of stem cell population maintenance
B	1902459	biological_process	positive regulation of stem cell population maintenance
B	1904949	cellular_component	ATPase complex
B	2000736	biological_process	regulation of stem cell differentiation
E	0046982	molecular_function	protein heterodimerization activity
F	0046982	molecular_function	protein heterodimerization activity

Functional Information from PROSITE/UniProt

site_id	PS00678
Number of Residues	15
Details	WD_REPEATS_1 Trp-Asp (WD) repeats signature. LLSAsdDhTVCLWDI

Chain	Residue	Details
B	LEU192-ILE206
B	LEU288-LEU302
B	LEU332-LEU346

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: N6-succinyllysine; alternate => ECO:0000269|PubMed:22389435

Chain	Residue	Details
E	LYS31
F	LYS31

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site_id	SWS_FT_FI2
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in UFM1); alternate => ECO:0000269|PubMed:30886146

Chain	Residue	Details
E	LYS31
A	SER3
F	LYS31

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861

Chain	Residue	Details
B	LYS4
A	LYS4

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site_id	SWS_FT_FI4
Number of Residues	2
Details	MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163

Chain	Residue	Details
B	THR10
A	THR10

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site_id	SWS_FT_FI5
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569

Chain	Residue	Details
B	SER95
A	SER95

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q60973

Chain	Residue	Details
B	LYS119
A	LYS119

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: N6-acetyllysine; alternate => ECO:0000250|UniProtKB:Q60973

Chain	Residue	Details
B	LYS159
A	LYS159

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site_id	SWS_FT_FI8
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163

Chain	Residue	Details
B	SER354
A	SER354

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site_id	SWS_FT_FI9
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate

Chain	Residue	Details
B	LYS4
A	LYS4

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site_id	SWS_FT_FI10
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:25772364, ECO:0007744|PubMed:28112733

Chain	Residue	Details
B	LYS159
A	LYS159

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site_id	SWS_FT_FI11
Number of Residues	4
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
B	LYS101
B	LYS155
A	LYS101
A	LYS155

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