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3CF2

Structure of P97/vcp in complex with ADP/AMP-PNP

Replaces:  1YPW
Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0000502cellular_componentproteasome complex
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0005811cellular_componentlipid droplet
A0005829cellular_componentcytosol
A0006281biological_processDNA repair
A0006302biological_processdouble-strand break repair
A0006511biological_processubiquitin-dependent protein catabolic process
A0006734biological_processNADH metabolic process
A0006888biological_processendoplasmic reticulum to Golgi vesicle-mediated transport
A0006914biological_processautophagy
A0006974biological_processDNA damage response
A0008289molecular_functionlipid binding
A0010494cellular_componentcytoplasmic stress granule
A0010498biological_processproteasomal protein catabolic process
A0010918biological_processpositive regulation of mitochondrial membrane potential
A0016236biological_processmacroautophagy
A0016567biological_processprotein ubiquitination
A0016787molecular_functionhydrolase activity
A0016887molecular_functionATP hydrolysis activity
A0019079biological_processviral genome replication
A0019903molecular_functionprotein phosphatase binding
A0019904molecular_functionprotein domain specific binding
A0019985biological_processtranslesion synthesis
A0030970biological_processretrograde protein transport, ER to cytosol
A0031334biological_processpositive regulation of protein-containing complex assembly
A0031593molecular_functionpolyubiquitin modification-dependent protein binding
A0031625molecular_functionubiquitin protein ligase binding
A0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
A0032510biological_processendosome to lysosome transport via multivesicular body sorting pathway
A0032991cellular_componentprotein-containing complex
A0033554biological_processcellular response to stress
A0034098cellular_componentVCP-NPL4-UFD1 AAA ATPase complex
A0034605biological_processcellular response to heat
A0035617biological_processstress granule disassembly
A0035800molecular_functiondeubiquitinase activator activity
A0035861cellular_componentsite of double-strand break
A0036297biological_processinterstrand cross-link repair
A0036435molecular_functionK48-linked polyubiquitin modification-dependent protein binding
A0036503biological_processERAD pathway
A0036513cellular_componentDerlin-1 retrotranslocation complex
A0042288molecular_functionMHC class I protein binding
A0042802molecular_functionidentical protein binding
A0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
A0043209cellular_componentmyelin sheath
A0043531molecular_functionADP binding
A0044389molecular_functionubiquitin-like protein ligase binding
A0044877molecular_functionprotein-containing complex binding
A0045202cellular_componentsynapse
A0045732biological_processpositive regulation of protein catabolic process
A0045879biological_processnegative regulation of smoothened signaling pathway
A0046034biological_processATP metabolic process
A0048471cellular_componentperinuclear region of cytoplasm
A0050807biological_processregulation of synapse organization
A0051228biological_processmitotic spindle disassembly
A0061857biological_processendoplasmic reticulum stress-induced pre-emptive quality control
A0070842biological_processaggresome assembly
A0071218biological_processcellular response to misfolded protein
A0072389biological_processflavin adenine dinucleotide catabolic process
A0090263biological_processpositive regulation of canonical Wnt signaling pathway
A0097352biological_processautophagosome maturation
A0098978cellular_componentglutamatergic synapse
A0106300biological_processprotein-DNA covalent cross-linking repair
A0120186biological_processnegative regulation of protein localization to chromatin
A0140036molecular_functionubiquitin-modified protein reader activity
A1901224biological_processpositive regulation of non-canonical NF-kappaB signal transduction
A1903006biological_processpositive regulation of protein K63-linked deubiquitination
A1903715biological_processregulation of aerobic respiration
A1903843biological_processcellular response to arsenite ion
A1903862biological_processpositive regulation of oxidative phosphorylation
A1904288molecular_functionBAT3 complex binding
A1904949cellular_componentATPase complex
A1905634biological_processregulation of protein localization to chromatin
A1990381molecular_functionubiquitin-specific protease binding
A1990730cellular_componentVCP-NSFL1C complex
A2000060biological_processpositive regulation of ubiquitin-dependent protein catabolic process
A2001171biological_processpositive regulation of ATP biosynthetic process
B0000166molecular_functionnucleotide binding
B0000502cellular_componentproteasome complex
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005783cellular_componentendoplasmic reticulum
B0005789cellular_componentendoplasmic reticulum membrane
B0005811cellular_componentlipid droplet
B0005829cellular_componentcytosol
B0006281biological_processDNA repair
B0006302biological_processdouble-strand break repair
B0006511biological_processubiquitin-dependent protein catabolic process
B0006734biological_processNADH metabolic process
B0006888biological_processendoplasmic reticulum to Golgi vesicle-mediated transport
B0006914biological_processautophagy
B0006974biological_processDNA damage response
B0008289molecular_functionlipid binding
B0010494cellular_componentcytoplasmic stress granule
B0010498biological_processproteasomal protein catabolic process
B0010918biological_processpositive regulation of mitochondrial membrane potential
B0016236biological_processmacroautophagy
B0016567biological_processprotein ubiquitination
B0016787molecular_functionhydrolase activity
B0016887molecular_functionATP hydrolysis activity
B0019079biological_processviral genome replication
B0019903molecular_functionprotein phosphatase binding
B0019904molecular_functionprotein domain specific binding
B0019985biological_processtranslesion synthesis
B0030970biological_processretrograde protein transport, ER to cytosol
B0031334biological_processpositive regulation of protein-containing complex assembly
B0031593molecular_functionpolyubiquitin modification-dependent protein binding
B0031625molecular_functionubiquitin protein ligase binding
B0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
B0032510biological_processendosome to lysosome transport via multivesicular body sorting pathway
B0032991cellular_componentprotein-containing complex
B0033554biological_processcellular response to stress
B0034098cellular_componentVCP-NPL4-UFD1 AAA ATPase complex
B0034605biological_processcellular response to heat
B0035617biological_processstress granule disassembly
B0035800molecular_functiondeubiquitinase activator activity
B0035861cellular_componentsite of double-strand break
B0036297biological_processinterstrand cross-link repair
B0036435molecular_functionK48-linked polyubiquitin modification-dependent protein binding
B0036503biological_processERAD pathway
B0036513cellular_componentDerlin-1 retrotranslocation complex
B0042288molecular_functionMHC class I protein binding
B0042802molecular_functionidentical protein binding
B0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
B0043209cellular_componentmyelin sheath
B0043531molecular_functionADP binding
B0044389molecular_functionubiquitin-like protein ligase binding
B0044877molecular_functionprotein-containing complex binding
B0045202cellular_componentsynapse
B0045732biological_processpositive regulation of protein catabolic process
B0045879biological_processnegative regulation of smoothened signaling pathway
B0046034biological_processATP metabolic process
B0048471cellular_componentperinuclear region of cytoplasm
B0050807biological_processregulation of synapse organization
B0051228biological_processmitotic spindle disassembly
B0061857biological_processendoplasmic reticulum stress-induced pre-emptive quality control
B0070842biological_processaggresome assembly
B0071218biological_processcellular response to misfolded protein
B0072389biological_processflavin adenine dinucleotide catabolic process
B0090263biological_processpositive regulation of canonical Wnt signaling pathway
B0097352biological_processautophagosome maturation
B0098978cellular_componentglutamatergic synapse
B0106300biological_processprotein-DNA covalent cross-linking repair
B0120186biological_processnegative regulation of protein localization to chromatin
B0140036molecular_functionubiquitin-modified protein reader activity
B1901224biological_processpositive regulation of non-canonical NF-kappaB signal transduction
B1903006biological_processpositive regulation of protein K63-linked deubiquitination
B1903715biological_processregulation of aerobic respiration
B1903843biological_processcellular response to arsenite ion
B1903862biological_processpositive regulation of oxidative phosphorylation
B1904288molecular_functionBAT3 complex binding
B1904949cellular_componentATPase complex
B1905634biological_processregulation of protein localization to chromatin
B1990381molecular_functionubiquitin-specific protease binding
B1990730cellular_componentVCP-NSFL1C complex
B2000060biological_processpositive regulation of ubiquitin-dependent protein catabolic process
B2001171biological_processpositive regulation of ATP biosynthetic process
C0000166molecular_functionnucleotide binding
C0000502cellular_componentproteasome complex
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005783cellular_componentendoplasmic reticulum
C0005789cellular_componentendoplasmic reticulum membrane
C0005811cellular_componentlipid droplet
C0005829cellular_componentcytosol
C0006281biological_processDNA repair
C0006302biological_processdouble-strand break repair
C0006511biological_processubiquitin-dependent protein catabolic process
C0006734biological_processNADH metabolic process
C0006888biological_processendoplasmic reticulum to Golgi vesicle-mediated transport
C0006914biological_processautophagy
C0006974biological_processDNA damage response
C0008289molecular_functionlipid binding
C0010494cellular_componentcytoplasmic stress granule
C0010498biological_processproteasomal protein catabolic process
C0010918biological_processpositive regulation of mitochondrial membrane potential
C0016236biological_processmacroautophagy
C0016567biological_processprotein ubiquitination
C0016787molecular_functionhydrolase activity
C0016887molecular_functionATP hydrolysis activity
C0019079biological_processviral genome replication
C0019903molecular_functionprotein phosphatase binding
C0019904molecular_functionprotein domain specific binding
C0019985biological_processtranslesion synthesis
C0030970biological_processretrograde protein transport, ER to cytosol
C0031334biological_processpositive regulation of protein-containing complex assembly
C0031593molecular_functionpolyubiquitin modification-dependent protein binding
C0031625molecular_functionubiquitin protein ligase binding
C0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
C0032510biological_processendosome to lysosome transport via multivesicular body sorting pathway
C0032991cellular_componentprotein-containing complex
C0033554biological_processcellular response to stress
C0034098cellular_componentVCP-NPL4-UFD1 AAA ATPase complex
C0034605biological_processcellular response to heat
C0035617biological_processstress granule disassembly
C0035800molecular_functiondeubiquitinase activator activity
C0035861cellular_componentsite of double-strand break
C0036297biological_processinterstrand cross-link repair
C0036435molecular_functionK48-linked polyubiquitin modification-dependent protein binding
C0036503biological_processERAD pathway
C0036513cellular_componentDerlin-1 retrotranslocation complex
C0042288molecular_functionMHC class I protein binding
C0042802molecular_functionidentical protein binding
C0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
C0043209cellular_componentmyelin sheath
C0043531molecular_functionADP binding
C0044389molecular_functionubiquitin-like protein ligase binding
C0044877molecular_functionprotein-containing complex binding
C0045202cellular_componentsynapse
C0045732biological_processpositive regulation of protein catabolic process
C0045879biological_processnegative regulation of smoothened signaling pathway
C0046034biological_processATP metabolic process
C0048471cellular_componentperinuclear region of cytoplasm
C0050807biological_processregulation of synapse organization
C0051228biological_processmitotic spindle disassembly
C0061857biological_processendoplasmic reticulum stress-induced pre-emptive quality control
C0070842biological_processaggresome assembly
C0071218biological_processcellular response to misfolded protein
C0072389biological_processflavin adenine dinucleotide catabolic process
C0090263biological_processpositive regulation of canonical Wnt signaling pathway
C0097352biological_processautophagosome maturation
C0098978cellular_componentglutamatergic synapse
C0106300biological_processprotein-DNA covalent cross-linking repair
C0120186biological_processnegative regulation of protein localization to chromatin
C0140036molecular_functionubiquitin-modified protein reader activity
C1901224biological_processpositive regulation of non-canonical NF-kappaB signal transduction
C1903006biological_processpositive regulation of protein K63-linked deubiquitination
C1903715biological_processregulation of aerobic respiration
C1903843biological_processcellular response to arsenite ion
C1903862biological_processpositive regulation of oxidative phosphorylation
C1904288molecular_functionBAT3 complex binding
C1904949cellular_componentATPase complex
C1905634biological_processregulation of protein localization to chromatin
C1990381molecular_functionubiquitin-specific protease binding
C1990730cellular_componentVCP-NSFL1C complex
C2000060biological_processpositive regulation of ubiquitin-dependent protein catabolic process
C2001171biological_processpositive regulation of ATP biosynthetic process
D0000166molecular_functionnucleotide binding
D0000502cellular_componentproteasome complex
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005783cellular_componentendoplasmic reticulum
D0005789cellular_componentendoplasmic reticulum membrane
D0005811cellular_componentlipid droplet
D0005829cellular_componentcytosol
D0006281biological_processDNA repair
D0006302biological_processdouble-strand break repair
D0006511biological_processubiquitin-dependent protein catabolic process
D0006734biological_processNADH metabolic process
D0006888biological_processendoplasmic reticulum to Golgi vesicle-mediated transport
D0006914biological_processautophagy
D0006974biological_processDNA damage response
D0008289molecular_functionlipid binding
D0010494cellular_componentcytoplasmic stress granule
D0010498biological_processproteasomal protein catabolic process
D0010918biological_processpositive regulation of mitochondrial membrane potential
D0016236biological_processmacroautophagy
D0016567biological_processprotein ubiquitination
D0016787molecular_functionhydrolase activity
D0016887molecular_functionATP hydrolysis activity
D0019079biological_processviral genome replication
D0019903molecular_functionprotein phosphatase binding
D0019904molecular_functionprotein domain specific binding
D0019985biological_processtranslesion synthesis
D0030970biological_processretrograde protein transport, ER to cytosol
D0031334biological_processpositive regulation of protein-containing complex assembly
D0031593molecular_functionpolyubiquitin modification-dependent protein binding
D0031625molecular_functionubiquitin protein ligase binding
D0032436biological_processpositive regulation of proteasomal ubiquitin-dependent protein catabolic process
D0032510biological_processendosome to lysosome transport via multivesicular body sorting pathway
D0032991cellular_componentprotein-containing complex
D0033554biological_processcellular response to stress
D0034098cellular_componentVCP-NPL4-UFD1 AAA ATPase complex
D0034605biological_processcellular response to heat
D0035617biological_processstress granule disassembly
D0035800molecular_functiondeubiquitinase activator activity
D0035861cellular_componentsite of double-strand break
D0036297biological_processinterstrand cross-link repair
D0036435molecular_functionK48-linked polyubiquitin modification-dependent protein binding
D0036503biological_processERAD pathway
D0036513cellular_componentDerlin-1 retrotranslocation complex
D0042288molecular_functionMHC class I protein binding
D0042802molecular_functionidentical protein binding
D0043161biological_processproteasome-mediated ubiquitin-dependent protein catabolic process
D0043209cellular_componentmyelin sheath
D0043531molecular_functionADP binding
D0044389molecular_functionubiquitin-like protein ligase binding
D0044877molecular_functionprotein-containing complex binding
D0045202cellular_componentsynapse
D0045732biological_processpositive regulation of protein catabolic process
D0045879biological_processnegative regulation of smoothened signaling pathway
D0046034biological_processATP metabolic process
D0048471cellular_componentperinuclear region of cytoplasm
D0050807biological_processregulation of synapse organization
D0051228biological_processmitotic spindle disassembly
D0061857biological_processendoplasmic reticulum stress-induced pre-emptive quality control
D0070842biological_processaggresome assembly
D0071218biological_processcellular response to misfolded protein
D0072389biological_processflavin adenine dinucleotide catabolic process
D0090263biological_processpositive regulation of canonical Wnt signaling pathway
D0097352biological_processautophagosome maturation
D0098978cellular_componentglutamatergic synapse
D0106300biological_processprotein-DNA covalent cross-linking repair
D0120186biological_processnegative regulation of protein localization to chromatin
D0140036molecular_functionubiquitin-modified protein reader activity
D1901224biological_processpositive regulation of non-canonical NF-kappaB signal transduction
D1903006biological_processpositive regulation of protein K63-linked deubiquitination
D1903715biological_processregulation of aerobic respiration
D1903843biological_processcellular response to arsenite ion
D1903862biological_processpositive regulation of oxidative phosphorylation
D1904288molecular_functionBAT3 complex binding
D1904949cellular_componentATPase complex
D1905634biological_processregulation of protein localization to chromatin
D1990381molecular_functionubiquitin-specific protease binding
D1990730cellular_componentVCP-NSFL1C complex
D2000060biological_processpositive regulation of ubiquitin-dependent protein catabolic process
D2001171biological_processpositive regulation of ATP biosynthetic process
Functional Information from PDB Data
site_idAC1
Number of Residues13
DetailsBINDING SITE FOR RESIDUE ADP A 807
ChainResidue
AASP205
AHIS384
AGLY408
AALA409
BARG359
AGLY207
AGLY248
ATHR249
AGLY250
ALYS251
ATHR252
ALEU253
AILE380

site_idAC2
Number of Residues15
DetailsBINDING SITE FOR RESIDUE ANP A 901
ChainResidue
AASP478
AILE479
APRO519
APRO520
AGLY521
ACYS522
AGLY523
ALYS524
ATHR525
ALEU526
AASP577
AASN624
AILE656
ATHR688
BARG635

site_idAC3
Number of Residues14
DetailsBINDING SITE FOR RESIDUE ADP B 807
ChainResidue
ALYS236
AARG359
BASP205
BGLY207
BGLY248
BTHR249
BGLY250
BLYS251
BTHR252
BLEU253
BILE380
BHIS384
BGLY408
BALA409

site_idAC4
Number of Residues15
DetailsBINDING SITE FOR RESIDUE ANP B 901
ChainResidue
AARG635
BASP478
BILE479
BPRO519
BPRO520
BGLY521
BCYS522
BGLY523
BLYS524
BTHR525
BLEU526
BASP577
BASN624
BILE656
BTHR688

site_idAC5
Number of Residues14
DetailsBINDING SITE FOR RESIDUE ADP C 807
ChainResidue
CASP205
CGLY207
CGLY248
CTHR249
CGLY250
CLYS251
CTHR252
CLEU253
CILE380
CHIS384
CGLY408
CALA409
DLYS236
DARG359

site_idAC6
Number of Residues15
DetailsBINDING SITE FOR RESIDUE ANP C 901
ChainResidue
CASP478
CILE479
CPRO519
CPRO520
CGLY521
CCYS522
CGLY523
CLYS524
CTHR525
CLEU526
CASP577
CASN624
CILE656
CTHR688
DARG635

site_idAC7
Number of Residues14
DetailsBINDING SITE FOR RESIDUE ADP D 807
ChainResidue
DALA409
CLYS236
CARG359
DASP205
DGLY207
DGLY248
DTHR249
DGLY250
DLYS251
DTHR252
DLEU253
DILE380
DHIS384
DGLY408

site_idAC8
Number of Residues15
DetailsBINDING SITE FOR RESIDUE ANP D 901
ChainResidue
CARG635
DASP478
DILE479
DPRO519
DPRO520
DGLY521
DCYS522
DGLY523
DLYS524
DTHR525
DLEU526
DASP577
DASN624
DILE656
DTHR688

Functional Information from PROSITE/UniProt
site_idPS00674
Number of Residues19
DetailsAAA AAA-protein family signature. ViVMaATNrpnsIDpALr.R
ChainResidueDetails
AVAL341-ARG359
AVAL617-ARG635

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues12
DetailsBINDING: BINDING => ECO:0000305|PubMed:11163219, ECO:0000305|PubMed:14988733
ChainResidueDetails
APRO247
DPRO247
DHIS384
DGLY521
AHIS384
AGLY521
BPRO247
BHIS384
BGLY521
CPRO247
CHIS384
CGLY521

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:P55072
ChainResidueDetails
AASN348
BASN348
CASN348
DASN348

site_idSWS_FT_FI3
Number of Residues4
DetailsMOD_RES: N-acetylalanine => ECO:0000250|UniProtKB:P55072
ChainResidueDetails
AALA2
BALA2
CALA2
DALA2

site_idSWS_FT_FI4
Number of Residues32
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P55072
ChainResidueDetails
ASER3
BSER7
BSER13
BSER37
BSER462
BSER702
BSER775
BSER787
CSER3
CSER7
CSER13
ASER7
CSER37
CSER462
CSER702
CSER775
CSER787
DSER3
DSER7
DSER13
DSER37
DSER462
ASER13
DSER702
DSER775
DSER787
ASER37
ASER462
ASER702
ASER775
ASER787
BSER3

site_idSWS_FT_FI5
Number of Residues4
DetailsMOD_RES: N6,N6,N6-trimethyllysine; by VCPKMT => ECO:0000269|PubMed:22948820
ChainResidueDetails
ALYS315
BLYS315
CLYS315
DLYS315

site_idSWS_FT_FI6
Number of Residues4
DetailsMOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:P55072
ChainResidueDetails
ATHR436
BTHR436
CTHR436
DTHR436

site_idSWS_FT_FI7
Number of Residues12
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:23806337
ChainResidueDetails
ALYS502
DLYS502
DLYS505
DLYS754
ALYS505
ALYS754
BLYS502
BLYS505
BLYS754
CLYS502
CLYS505
CLYS754

site_idSWS_FT_FI8
Number of Residues4
DetailsMOD_RES: N6-succinyllysine; alternate => ECO:0007744|PubMed:23806337
ChainResidueDetails
ALYS668
BLYS668
CLYS668
DLYS668

site_idSWS_FT_FI9
Number of Residues4
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:21183079
ChainResidueDetails
ASER770
BSER770
CSER770
DSER770

site_idSWS_FT_FI10
Number of Residues4
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:15592455
ChainResidueDetails
ATYR805
BTYR805
CTYR805
DTYR805

site_idSWS_FT_FI11
Number of Residues12
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0000250|UniProtKB:P55072
ChainResidueDetails
ALYS8
DLYS8
DLYS18
ALYS18
BLYS8
BLYS18
CLYS8
CLYS18

218853

PDB entries from 2024-04-24

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