3CE0

Human poly(ADP-ribose) polymerase 3, catalytic fragment in complex with an inhibitor PJ34

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003950	molecular_function	NAD+ poly-ADP-ribosyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE P34 A 601

Chain	Residue
A	ASP284
A	GLU514
A	TRP383
A	HIS384
A	GLY385
A	TYR414
A	PHE415
A	LYS421
A	SER422
A	TYR425

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	28
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Modified residue: {"description":"ADP-ribosyl aspartic acid","evidences":[{"source":"PubMed","id":"25043379","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	5
Details	Modified residue: {"description":"ADP-ribosyl glutamic acid","evidences":[{"source":"PubMed","id":"25043379","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1a26

Chain	Residue	Details
A	GLU514
A	TYR425

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