3CD3

Crystal structure of phosphorylated human feline sarcoma viral oncogene homologue (v-FES) in complex with staurosporine and a consensus peptide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004713	molecular_function	protein tyrosine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 904

Chain	Residue
A	ASN766
A	GLN767
A	ARG770

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site_id	AC3
Number of Residues	14
Details	BINDING SITE FOR RESIDUE STU A 901

Chain	Residue
A	GLU637
A	LEU638
A	GLY642
A	ASP643
A	ARG687
A	LEU690
A	SER700
A	ASP701
A	ILE567
A	GLY568
A	ARG569
A	ALA588
A	GLU607
A	MET636

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site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE STU A 902

Chain	Residue
A	ASP583
A	THR585
A	ARG621
A	LEU622
A	ILE623

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site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE STU A 903

Chain	Residue
A	HIS456
A	LYS553
A	TRP554
A	GLU559
A	ARG581

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Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGRGNFGEVFsGrlradntl..........VAVK

Chain	Residue	Details
A	ILE567-LYS590

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site_id	PS00109
Number of Residues	13
Details	PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. CIHrDLAARNCLV

Chain	Residue	Details
A	CYS679-VAL691

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028

Chain	Residue	Details
A	ASP683

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site_id	SWS_FT_FI2
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00159

Chain	Residue	Details
A	ILE567
A	LYS590

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: Phosphotyrosine; by autocatalysis => ECO:0000269|PubMed:15485904, ECO:0000269|PubMed:18046454, ECO:0000269|PubMed:18775312, ECO:0000269|PubMed:19382747, ECO:0000269|PubMed:7687763, ECO:0007744|PubMed:19369195

Chain	Residue	Details
A	PTR713

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site_id	SWS_FT_FI4
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:19369195

Chain	Residue	Details
A	SER716

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	ARG687
A	ASP683

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site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	ASP683
A	ALA685

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site_id	CSA3
Number of Residues	3
Details	Annotated By Reference To The Literature 1ir3

Chain	Residue	Details
A	ASP683
A	ALA685
A	ASN688

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