3CBJ
Chagasin-Cathepsin B complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006508 | biological_process | proteolysis |
| A | 0008234 | molecular_function | cysteine-type peptidase activity |
| B | 0004869 | molecular_function | cysteine-type endopeptidase inhibitor activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0009986 | cellular_component | cell surface |
| B | 0020016 | cellular_component | ciliary pocket |
| B | 0030414 | molecular_function | peptidase inhibitor activity |
| B | 0031410 | cellular_component | cytoplasmic vesicle |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PO4 A 261 |
| Chain | Residue |
| A | CYS62 |
| A | PHE82 |
| A | LYS86 |
| A | LYS130 |
| A | TYR140 |
| A | LYS144 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE PO4 A 262 |
| Chain | Residue |
| A | LYS127 |
| A | SER129 |
| B | ASN110 |
| A | GLU57 |
| A | ARG101 |
| A | PRO126 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PO4 B 111 |
| Chain | Residue |
| B | GLU23 |
| B | HIS72 |
| B | HIS74 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PO4 A 263 |
| Chain | Residue |
| A | ASN155 |
| A | ASP227 |
| A | LYS232 |
| A | SER244 |
Functional Information from PROSITE/UniProt
| site_id | PS00639 |
| Number of Residues | 11 |
| Details | THIOL_PROTEASE_HIS Eukaryotic thiol (cysteine) proteases histidine active site. GGHAIRILGWG |
| Chain | Residue | Details |
| A | GLY197-GLY207 |
| site_id | PS00640 |
| Number of Residues | 20 |
| Details | THIOL_PROTEASE_ASN Eukaryotic thiol (cysteine) proteases asparagine active site. YWLvANSWntdWGdnGFFkI |
| Chain | Residue | Details |
| A | TYR214-ILE233 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | Active site: {"evidences":[{"source":"PubMed","id":"9299326","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"P10605","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"3463996","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 5 |
| Details | Motif: {"description":"BC loop","evidences":[{"source":"PubMed","id":"17502099","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17561110","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18515357","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19143838","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 9 |
| Details | Motif: {"description":"DE loop","evidences":[{"source":"PubMed","id":"17502099","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17561110","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18515357","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19143838","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 9 |
| Details | Motif: {"description":"FG loop","evidences":[{"source":"PubMed","id":"17502099","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17561110","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"18515357","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19143838","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 9pap |
| Chain | Residue | Details |
| A | HIS199 | |
| A | ASN219 | |
| A | GLN23 |
