3C9A

High Resolution Crystal Structure of Argos bound to the EGF domain of Spitz

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0005154	molecular_function	epidermal growth factor receptor binding
C	0007173	biological_process	epidermal growth factor receptor signaling pathway
C	0048018	molecular_function	receptor ligand activity
D	0005154	molecular_function	epidermal growth factor receptor binding
D	0007173	biological_process	epidermal growth factor receptor signaling pathway
D	0048018	molecular_function	receptor ligand activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE BR B 1

Chain	Residue
B	ARG135
B	CYS139
B	CYS260

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE BR A 2

Chain	Residue
A	ARG135
A	CYS139
A	CYS260

---

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE BR A 3

Chain	Residue
A	ILE102
D	HIS68

---

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE BR A 4

Chain	Residue
A	TYR339
B	HIS392
A	PRO331

---

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE BR A 7

Chain	Residue
A	SER395
B	PRO337

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE BR A 9

Chain	Residue
A	SER263
A	GLY265
A	GLU267

---

site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE BR A 10

Chain	Residue
A	CYS382
A	CYS388

---

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE BR B 11

Chain	Residue
A	ASN334
B	HIS286
B	ALA399

---

site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE BR B 12

Chain	Residue
A	GLN283
B	LEU264

---

site_id	BC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE BR B 13

Chain	Residue
B	PHE294
B	THR327

---

site_id	BC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE BR B 14

Chain	Residue
B	GLN394
B	SER395

---

site_id	BC3
Number of Residues	1
Details	BINDING SITE FOR RESIDUE BR B 15

Chain	Residue
B	GLN283

---

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE BR B 16

Chain	Residue
A	PRO118
B	GLY265
B	GLU267
B	ASP268

---

site_id	BC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE BR A 17

Chain	Residue
A	THR410
A	SER412
C	THR57

---

site_id	BC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE BR C 18

Chain	Residue
C	GLU56
C	THR57

---

Functional Information from PROSITE/UniProt

site_id	PS00022
Number of Residues	12
Details	EGF_1 EGF-like domain signature 1. CeCaiGfmGQrC

Chain	Residue	Details
C	CYS82-CYS93

---

site_id	PS01186
Number of Residues	12
Details	EGF_2 EGF-like domain signature 2. CeCaiGFmgqr....C

Chain	Residue	Details
C	CYS82-CYS93

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	84
Details	Repeat: {"description":"Two-fingered domain 1 part 1","evidences":[{"source":"PubMed","id":"18500331","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	44
Details	Repeat: {"description":"Two-fingered domain 1 part 2","evidences":[{"source":"PubMed","id":"18500331","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	108
Details	Repeat: {"description":"Two-fingered domain 2","evidences":[{"source":"PubMed","id":"18500331","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	66
Details	Repeat: {"description":"Two-fingered domain 3","evidences":[{"source":"PubMed","id":"18500331","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	88
Details	Domain: {"description":"EGF-like","evidences":[{"source":"PROSITE-ProRule","id":"PRU00076","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---