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3C98

Revised structure of the munc18a-syntaxin1 complex

Replaces:  1DN1
Functional Information from GO Data
ChainGOidnamespacecontents
A0000149molecular_functionSNARE binding
A0002576biological_processplatelet degranulation
A0003006biological_processdevelopmental process involved in reproduction
A0005515molecular_functionprotein binding
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0006886biological_processintracellular protein transport
A0006887biological_processexocytosis
A0006904biological_processvesicle docking involved in exocytosis
A0007269biological_processneurotransmitter secretion
A0007274biological_processneuromuscular synaptic transmission
A0007412biological_processaxon target recognition
A0010807biological_processregulation of synaptic vesicle priming
A0015031biological_processprotein transport
A0016020cellular_componentmembrane
A0016082biological_processsynaptic vesicle priming
A0016188biological_processsynaptic vesicle maturation
A0016192biological_processvesicle-mediated transport
A0017075molecular_functionsyntaxin-1 binding
A0019901molecular_functionprotein kinase binding
A0019904molecular_functionprotein domain specific binding
A0019905molecular_functionsyntaxin binding
A0030141cellular_componentsecretory granule
A0030424cellular_componentaxon
A0031091cellular_componentplatelet alpha granule
A0031333biological_processnegative regulation of protein-containing complex assembly
A0031338biological_processregulation of vesicle fusion
A0032229biological_processnegative regulation of synaptic transmission, GABAergic
A0032355biological_processresponse to estradiol
A0032991cellular_componentprotein-containing complex
A0035493biological_processSNARE complex assembly
A0035544biological_processnegative regulation of SNARE complex assembly
A0042802molecular_functionidentical protein binding
A0043195cellular_componentterminal bouton
A0043274molecular_functionphospholipase binding
A0043306biological_processpositive regulation of mast cell degranulation
A0043524biological_processnegative regulation of neuron apoptotic process
A0045335cellular_componentphagocytic vesicle
A0045921biological_processpositive regulation of exocytosis
A0045956biological_processpositive regulation of calcium ion-dependent exocytosis
A0048471cellular_componentperinuclear region of cytoplasm
A0050821biological_processprotein stabilization
A0051402biological_processneuron apoptotic process
A0051649biological_processestablishment of localization in cell
A0060090molecular_functionmolecular adaptor activity
A0060292biological_processlong-term synaptic depression
A0070527biological_processplatelet aggregation
A0071346biological_processcellular response to type II interferon
A0072659biological_processprotein localization to plasma membrane
A0098688cellular_componentparallel fiber to Purkinje cell synapse
A0098793cellular_componentpresynapse
A0098794cellular_componentpostsynapse
A0098831cellular_componentpresynaptic active zone cytoplasmic component
A0098888cellular_componentextrinsic component of presynaptic membrane
A0098978cellular_componentglutamatergic synapse
A0099523cellular_componentpresynaptic cytosol
A0099525biological_processpresynaptic dense core vesicle exocytosis
A0106022biological_processpositive regulation of vesicle docking
A1903296biological_processpositive regulation of glutamate secretion, neurotransmission
A2000367biological_processregulation of acrosomal vesicle exocytosis
B0000149molecular_functionSNARE binding
B0001669cellular_componentacrosomal vesicle
B0001956biological_processpositive regulation of neurotransmitter secretion
B0005484molecular_functionSNAP receptor activity
B0005515molecular_functionprotein binding
B0005886cellular_componentplasma membrane
B0006836biological_processneurotransmitter transport
B0006886biological_processintracellular protein transport
B0006887biological_processexocytosis
B0006906biological_processvesicle fusion
B0008021cellular_componentsynaptic vesicle
B0008076cellular_componentvoltage-gated potassium channel complex
B0009629biological_processresponse to gravity
B0010701biological_processpositive regulation of norepinephrine secretion
B0010807biological_processregulation of synaptic vesicle priming
B0012505cellular_componentendomembrane system
B0016020cellular_componentmembrane
B0016079biological_processsynaptic vesicle exocytosis
B0016081biological_processsynaptic vesicle docking
B0016192biological_processvesicle-mediated transport
B0016925biological_processprotein sumoylation
B0017022molecular_functionmyosin binding
B0017156biological_processcalcium-ion regulated exocytosis
B0017157biological_processregulation of exocytosis
B0019855molecular_functioncalcium channel inhibitor activity
B0019869molecular_functionchloride channel inhibitor activity
B0019900molecular_functionkinase binding
B0030073biological_processinsulin secretion
B0030141cellular_componentsecretory granule
B0030424cellular_componentaxon
B0030672cellular_componentsynaptic vesicle membrane
B0030674molecular_functionprotein-macromolecule adaptor activity
B0031201cellular_componentSNARE complex
B0031410cellular_componentcytoplasmic vesicle
B0031965cellular_componentnuclear membrane
B0032028molecular_functionmyosin head/neck binding
B0032940biological_processsecretion by cell
B0032991cellular_componentprotein-containing complex
B0033605biological_processpositive regulation of catecholamine secretion
B0035493biological_processSNARE complex assembly
B0042641cellular_componentactomyosin
B0042734cellular_componentpresynaptic membrane
B0042802molecular_functionidentical protein binding
B0043005cellular_componentneuron projection
B0043008molecular_functionATP-dependent protein binding
B0044325molecular_functiontransmembrane transporter binding
B0044877molecular_functionprotein-containing complex binding
B0045055biological_processregulated exocytosis
B0045202cellular_componentsynapse
B0045921biological_processpositive regulation of exocytosis
B0045956biological_processpositive regulation of calcium ion-dependent exocytosis
B0046879biological_processhormone secretion
B0048278biological_processvesicle docking
B0048306molecular_functioncalcium-dependent protein binding
B0048488biological_processsynaptic vesicle endocytosis
B0048787cellular_componentpresynaptic active zone membrane
B0070032cellular_componentsynaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex
B0070033cellular_componentsynaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex
B0070044cellular_componentsynaptobrevin 2-SNAP-25-syntaxin-1a complex
B0072657biological_processprotein localization to membrane
B0098685cellular_componentSchaffer collateral - CA1 synapse
B0098793cellular_componentpresynapse
B0098815biological_processmodulation of excitatory postsynaptic potential
B0098839cellular_componentpostsynaptic density membrane
B0098978cellular_componentglutamatergic synapse
B1903530biological_processregulation of secretion by cell
B2000463biological_processpositive regulation of excitatory postsynaptic potential
Functional Information from PROSITE/UniProt
site_idPS00914
Number of Residues40
DetailsSYNTAXIN Syntaxin / epimorphin family signature. RhseIikLEnsIrELhdMFmdMamlVesQGemIDrIEyn.V
ChainResidueDetails
BARG198-VAL237

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsModified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"22673903","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues41
DetailsCoiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails

site_idSWS_FT_FI3
Number of Residues1
DetailsModified residue: {"description":"Phosphoserine; by DAPK1","evidences":[{"source":"PubMed","id":"12730201","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails

239492

PDB entries from 2025-07-30

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