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3C8N

Crystal structure of apo-FGD1 from Mycobacterium tuberculosis

Functional Information from GO Data
ChainGOidnamespacecontents
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0005975biological_processcarbohydrate metabolic process
A0009274cellular_componentpeptidoglycan-based cell wall
A0016491molecular_functionoxidoreductase activity
A0016614molecular_functionoxidoreductase activity, acting on CH-OH group of donors
A0016705molecular_functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
A0045454biological_processcell redox homeostasis
A0052749molecular_functionglucose-6-phosphate dehydrogenase (coenzyme F420) activity
A0070967molecular_functioncoenzyme F420 binding
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0005975biological_processcarbohydrate metabolic process
B0009274cellular_componentpeptidoglycan-based cell wall
B0016491molecular_functionoxidoreductase activity
B0016614molecular_functionoxidoreductase activity, acting on CH-OH group of donors
B0016705molecular_functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
B0045454biological_processcell redox homeostasis
B0052749molecular_functionglucose-6-phosphate dehydrogenase (coenzyme F420) activity
B0070967molecular_functioncoenzyme F420 binding
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0005975biological_processcarbohydrate metabolic process
C0009274cellular_componentpeptidoglycan-based cell wall
C0016491molecular_functionoxidoreductase activity
C0016614molecular_functionoxidoreductase activity, acting on CH-OH group of donors
C0016705molecular_functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
C0045454biological_processcell redox homeostasis
C0052749molecular_functionglucose-6-phosphate dehydrogenase (coenzyme F420) activity
C0070967molecular_functioncoenzyme F420 binding
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0005975biological_processcarbohydrate metabolic process
D0009274cellular_componentpeptidoglycan-based cell wall
D0016491molecular_functionoxidoreductase activity
D0016614molecular_functionoxidoreductase activity, acting on CH-OH group of donors
D0016705molecular_functionoxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
D0045454biological_processcell redox homeostasis
D0052749molecular_functionglucose-6-phosphate dehydrogenase (coenzyme F420) activity
D0070967molecular_functioncoenzyme F420 binding
Functional Information from PROSITE/UniProt
site_idPS00683
Number of Residues11
DetailsRHODANESE_2 Rhodanese C-terminal signature. AtgYEGAWpEF
ChainResidueDetails
AALA115-PHE125

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsACT_SITE: Proton donor => ECO:0000305|PubMed:18434308
ChainResidueDetails
AHIS40
BHIS40
CHIS40
DHIS40

site_idSWS_FT_FI2
Number of Residues4
DetailsACT_SITE: Proton acceptor => ECO:0000305|PubMed:18434308
ChainResidueDetails
AGLU109
BGLU109
CGLU109
DGLU109

site_idSWS_FT_FI3
Number of Residues16
DetailsBINDING: BINDING => ECO:0000305|PubMed:18434308, ECO:0007744|PDB:3B4Y
ChainResidueDetails
AASP39
CTHR107
CASN112
CGLY177
DASP39
DTHR107
DASN112
DGLY177
ATHR107
AASN112
AGLY177
BASP39
BTHR107
BASN112
BGLY177
CASP39

site_idSWS_FT_FI4
Number of Residues24
DetailsBINDING: BINDING => ECO:0000305|PubMed:18434308
ChainResidueDetails
ATHR76
BLYS198
BLYS259
BARG283
CTHR76
CALA180
CTHR195
CLYS198
CLYS259
CARG283
DTHR76
AALA180
DALA180
DTHR195
DLYS198
DLYS259
DARG283
ATHR195
ALYS198
ALYS259
AARG283
BTHR76
BALA180
BTHR195

Catalytic Information from CSA
site_idCSA1
Number of Residues3
DetailsAnnotated By Reference To The Literature 1rhc
ChainResidueDetails
AGLU109
ATRP44
AHIS40

site_idCSA2
Number of Residues2
DetailsAnnotated By Reference To The Literature 1rhc
ChainResidueDetails
BGLU109
BHIS40

site_idCSA3
Number of Residues3
DetailsAnnotated By Reference To The Literature 1rhc
ChainResidueDetails
CGLU109
CTRP44
CHIS40

site_idCSA4
Number of Residues3
DetailsAnnotated By Reference To The Literature 1rhc
ChainResidueDetails
DGLU109
DTRP44
DHIS40

238268

PDB entries from 2025-07-02

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