3C5H

Crystal structure of the Ras homolog domain of human GRLF1 (p190RhoGAP)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003924	molecular_function	GTPase activity
A	0005525	molecular_function	GTP binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 302

Chain	Residue
A	SER36
A	GLU95
A	GNP301
A	HOH389
A	HOH390

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site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 303

Chain	Residue
A	HOH328
A	HOH337
A	HOH312
A	HOH314
A	HOH318
A	HOH323

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site_id	AC3
Number of Residues	26
Details	BINDING SITE FOR RESIDUE GNP A 301

Chain	Residue
A	LYS28
A	GLY32
A	ILE33
A	GLY34
A	LYS35
A	SER36
A	CYS37
A	LEU52
A	ASP53
A	SER56
A	GLU95
A	THR97
A	LYS201
A	ASP203
A	SER229
A	ALA230
A	ARG231
A	MG302
A	HOH311
A	HOH316
A	HOH319
A	HOH389
A	HOH390
A	HOH394
A	HOH395
A	HOH396

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site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE UNX A 304

Chain	Residue
A	TYR116
A	ILE117

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site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE UNX A 305

Chain	Residue
A	VAL43
A	ARG44
A	MET132

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site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE UNX A 307

Chain	Residue
A	ASN235
A	ASP237
A	LEU238

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site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE UNX A 308

Chain	Residue
A	PHE42
A	ASP237

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	7
Details	BINDING: BINDING => ECO:0000269|Ref.23, ECO:0007744|PDB:3C5H

Chain	Residue	Details
A	LYS28
A	ILE33
A	LEU52
A	SER56
A	GLU95
A	LYS201
A	SER229

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
A	GLN143

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