3C5G

Structure of a ternary complex of the R517K Pol lambda mutant

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003887	molecular_function	DNA-directed DNA polymerase activity
A	0006281	biological_process	DNA repair
A	0016779	molecular_function	nucleotidyltransferase activity
A	0034061	molecular_function	DNA polymerase activity
B	0003677	molecular_function	DNA binding
B	0003887	molecular_function	DNA-directed DNA polymerase activity
B	0006281	biological_process	DNA repair
B	0016779	molecular_function	nucleotidyltransferase activity
B	0034061	molecular_function	DNA polymerase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 602

Chain	Residue
A	ASP427
A	ASP429
A	D3T576
A	NA803
A	HOH976

---

site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA A 803

Chain	Residue
A	MG602
P	HOH671
A	ASP427
A	ASP429
A	ASP490
A	D3T576

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA A 804

Chain	Residue
A	SER339
A	ILE341
A	ALA344
P	DA5
P	HOH170
P	HOH311

---

site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA A 805

Chain	Residue
A	CYS300
A	ILE302
A	PRO303
A	ILE305
B	HOH953
D	DC3

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE EDO T 2801

Chain	Residue
D	DG1
D	DC2
T	DG2
T	DG3
T	HOH619

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA P 807

Chain	Residue
A	GLN372
A	HOH866
A	HOH934
P	DG3
P	DT4
P	HOH342

---

site_id	AC7
Number of Residues	22
Details	BINDING SITE FOR RESIDUE D3T B 577

Chain	Residue
B	ARG386
B	GLY416
B	SER417
B	ARG420
B	GLY426
B	ASP427
B	ASP429
B	TYR505
B	PHE506
B	GLY508
B	ALA510
B	ASN513
B	MG601
B	NA802
B	HOH840
B	HOH984
B	HOH1008
B	HOH1067
B	HOH1098
Q	2DT6
Q	HOH16
U	DA5

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG B 601

Chain	Residue
B	ASP427
B	ASP429
B	D3T577
B	NA802
B	HOH1067

---

site_id	AC9
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA B 801

Chain	Residue
B	SER339
B	ILE341
B	ALA344
Q	DA5
Q	HOH7
Q	HOH12

---

site_id	BC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA B 802

Chain	Residue
B	ASP427
B	ASP429
B	ASP490
B	D3T577
B	MG601
Q	HOH16

---

site_id	BC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE NA B 806

Chain	Residue
A	LYS307
B	CYS300
B	ILE302
B	ILE305
E	DC3

---

site_id	BC3
Number of Residues	22
Details	BINDING SITE FOR RESIDUE D3T A 576

Chain	Residue
T	DA5
A	ARG386
A	GLY416
A	SER417
A	ARG420
A	GLY426
A	ASP427
A	ASP429
A	TYR505
A	PHE506
A	GLY508
A	ALA510
A	ASN513
A	MG602
A	NA803
A	HOH976
A	HOH1125
A	HOH1126
A	HOH1128
A	HOH1129
P	2DT6
P	HOH671

---

site_id	BC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE NA B 808

Chain	Residue
B	GLU396
B	GLN400
B	CYS412
B	HOH947
B	HOH949
B	HOH1076

---

Functional Information from PROSITE/UniProt

site_id	PS00522
Number of Residues	20
Details	DNA_POLYMERASE_X DNA polymerase family X signature. GSYrRGkatCgDVDVLIthP

Chain	Residue	Details
A	GLY416-PRO435

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	ACT_SITE: Schiff-base intermediate with DNA => ECO:0000269|PubMed:11457865

Chain	Residue	Details
A	LYS312
B	LYS312

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFP, ECO:0007744|PDB:2PFQ

Chain	Residue	Details
A	ARG386
A	SER417
A	GLY426
A	ASN513
B	ARG386
B	SER417
B	GLY426
B	ASN513

---

site_id	SWS_FT_FI3
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269|PubMed:17475573, ECO:0007744|PDB:2PFO, ECO:0007744|PDB:2PFQ

Chain	Residue	Details
A	ASP427
A	ASP429
A	ASP490
B	ASP427
B	ASP429
B	ASP490

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1jms

Chain	Residue	Details
A	ASP490

---

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1jms

Chain	Residue	Details
B	ASP490

---