3C3W
Crystal Structure of the Mycobacterium tuberculosis Hypoxic Response Regulator DosR
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000160 | biological_process | phosphorelay signal transduction system |
| A | 0001666 | biological_process | response to hypoxia |
| A | 0003677 | molecular_function | DNA binding |
| A | 0003700 | molecular_function | DNA-binding transcription factor activity |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0006355 | biological_process | regulation of DNA-templated transcription |
| A | 0009274 | cellular_component | peptidoglycan-based cell wall |
| A | 0022611 | biological_process | dormancy process |
| A | 0044161 | cellular_component | host cell cytoplasmic vesicle |
| A | 0045893 | biological_process | positive regulation of DNA-templated transcription |
| A | 0072493 | cellular_component | host cell endosome lumen |
| B | 0000160 | biological_process | phosphorelay signal transduction system |
| B | 0001666 | biological_process | response to hypoxia |
| B | 0003677 | molecular_function | DNA binding |
| B | 0003700 | molecular_function | DNA-binding transcription factor activity |
| B | 0005615 | cellular_component | extracellular space |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0005829 | cellular_component | cytosol |
| B | 0005886 | cellular_component | plasma membrane |
| B | 0006355 | biological_process | regulation of DNA-templated transcription |
| B | 0009274 | cellular_component | peptidoglycan-based cell wall |
| B | 0022611 | biological_process | dormancy process |
| B | 0044161 | cellular_component | host cell cytoplasmic vesicle |
| B | 0045893 | biological_process | positive regulation of DNA-templated transcription |
| B | 0072493 | cellular_component | host cell endosome lumen |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 226 |
| Chain | Residue |
| A | ARG67 |
| A | ARG113 |
| A | ASP117 |
| B | ARG67 |
| B | ARG113 |
| B | ASP117 |
Functional Information from PROSITE/UniProt
| site_id | PS00622 |
| Number of Residues | 28 |
| Details | HTH_LUXR_1 LuxR-type HTH domain signature. GltNkqIAdrMfLaekTVknYvsRLlaK |
| Chain | Residue | Details |
| A | GLY164-LYS191 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 232 |
| Details | Domain: {"description":"Response regulatory","evidences":[{"source":"PROSITE-ProRule","id":"PRU00169","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 130 |
| Details | Domain: {"description":"HTH luxR-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00411","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 38 |
| Details | DNA binding: {"description":"H-T-H motif","evidences":[{"source":"PROSITE-ProRule","id":"PRU00411","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"4-aspartylphosphate","evidences":[{"source":"PROSITE-ProRule","id":"PRU00169","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15033981","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"15073296","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Modified residue: {"description":"Phosphothreonine; by PknH","evidences":[{"source":"PubMed","id":"20630871","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
