3C3W

Crystal Structure of the Mycobacterium tuberculosis Hypoxic Response Regulator DosR

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000160	biological_process	phosphorelay signal transduction system
A	0001666	biological_process	response to hypoxia
A	0003677	molecular_function	DNA binding
A	0003700	molecular_function	DNA-binding transcription factor activity
A	0005615	cellular_component	extracellular space
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006355	biological_process	regulation of DNA-templated transcription
A	0009274	cellular_component	peptidoglycan-based cell wall
A	0022611	biological_process	dormancy process
A	0044161	cellular_component	host cell cytoplasmic vesicle
A	0045893	biological_process	positive regulation of DNA-templated transcription
A	0072493	cellular_component	host cell endosome lumen
B	0000160	biological_process	phosphorelay signal transduction system
B	0001666	biological_process	response to hypoxia
B	0003677	molecular_function	DNA binding
B	0003700	molecular_function	DNA-binding transcription factor activity
B	0005615	cellular_component	extracellular space
B	0005737	cellular_component	cytoplasm
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006355	biological_process	regulation of DNA-templated transcription
B	0009274	cellular_component	peptidoglycan-based cell wall
B	0022611	biological_process	dormancy process
B	0044161	cellular_component	host cell cytoplasmic vesicle
B	0045893	biological_process	positive regulation of DNA-templated transcription
B	0072493	cellular_component	host cell endosome lumen

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 226

Chain	Residue
A	ARG67
A	ARG113
A	ASP117
B	ARG67
B	ARG113
B	ASP117

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Functional Information from PROSITE/UniProt

site_id	PS00622
Number of Residues	28
Details	HTH_LUXR_1 LuxR-type HTH domain signature. GltNkqIAdrMfLaekTVknYvsRLlaK

Chain	Residue	Details
A	GLY164-LYS191

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	38
Details	DNA_BIND: H-T-H motif => ECO:0000255|PROSITE-ProRule:PRU00411

Chain	Residue	Details
A	ASN167-SER186
B	ASN167-SER186

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site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: 4-aspartylphosphate => ECO:0000255|PROSITE-ProRule:PRU00169, ECO:0000305|PubMed:15033981, ECO:0000305|PubMed:15073296

Chain	Residue	Details
A	ASP54
B	ASP54

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site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: Phosphothreonine; by PknH => ECO:0000269|PubMed:20630871

Chain	Residue	Details
A	THR198
A	THR205
B	THR198
B	THR205

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