3C35

Crystal structure of GluR5 ligand-binding core in complex with cesium at 1.97 Angstrom resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CS A 301

Chain	Residue
A	GLU96
A	ILE99
A	ASP100

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CS B 302

Chain	Residue
B	GLU96
B	ILE99
B	ASP100

---

site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CS A 303

Chain	Residue
A	SER22
B	LEU181

---

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CS A 304

Chain	Residue
A	ASN45
A	PHE49
A	SER44

---

site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CS A 305

Chain	Residue
A	LYS150
A	GLU155

---

site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CS A 306

Chain	Residue
A	LEU181
B	SER22

---

site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CS B 307

Chain	Residue
B	THR118
B	ILE120
B	ASP121

---

site_id	AC8
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CS B 308

Chain	Residue
B	SER44
B	ASN45
B	PHE49

---

site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CS A 309

Chain	Residue
A	THR118
A	ILE120

---

site_id	BC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CS B 310

Chain	Residue
B	LYS150
B	GLU155

---

site_id	BC2
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CS B 311

Chain	Residue
B	CYS256
B	PRO257

---

site_id	BC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CS B 312

Chain	Residue
B	PRO119
B	ASP125

---

site_id	BC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CS B 313

Chain	Residue
B	ASN29
B	TYR51
B	ASP52

---

site_id	BC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL A 314

Chain	Residue
A	LYS103
A	ARG227
B	LYS103

---

site_id	BC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE KAI A 401

Chain	Residue
A	GLU13
A	TYR61
A	PRO88
A	THR90
A	ARG95
A	GLY140
A	SER141
A	THR142
A	GLU190

---

site_id	BC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE KAI B 401

Chain	Residue
B	GLU13
B	TYR61
B	PRO88
B	THR90
B	ARG95
B	GLY140
B	SER141
B	THR142
B	GLU190

---

site_id	BC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 402

Chain	Residue
A	LYS60
A	TYR61
A	GLY62
A	ALA63
A	ARG138
A	ASP139

---

site_id	BC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE GOL B 402

Chain	Residue
B	LYS60
B	TYR61
B	GLY62
B	ARG138
B	ASP139

---

site_id	CC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL A 403

Chain	Residue
A	SER213
A	LYS214
B	PRO104
B	MET106
B	THR107
B	GLN238

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15710405","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1YCJ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"15710405","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15721240","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1YCJ","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by PKC","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine; by PKC","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---