Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3BWN

L-tryptophan aminotransferase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004021	molecular_function	L-alanine:2-oxoglutarate aminotransferase activity
A	0004838	molecular_function	L-tyrosine-2-oxoglutarate transaminase activity
A	0005515	molecular_function	protein binding
A	0005737	cellular_component	cytoplasm
A	0008483	molecular_function	transaminase activity
A	0009641	biological_process	shade avoidance
A	0009684	biological_process	indoleacetic acid biosynthetic process
A	0009723	biological_process	response to ethylene
A	0009793	biological_process	embryo development ending in seed dormancy
A	0009851	biological_process	auxin biosynthetic process
A	0009908	biological_process	flower development
A	0009926	biological_process	auxin polar transport
A	0009958	biological_process	positive gravitropism
A	0010078	biological_process	maintenance of root meristem identity
A	0010087	biological_process	phloem or xylem histogenesis
A	0010588	biological_process	cotyledon vascular tissue pattern formation
A	0016846	molecular_function	carbon-sulfur lyase activity
A	0030170	molecular_function	pyridoxal phosphate binding
A	0042742	biological_process	defense response to bacterium
A	0047312	molecular_function	L-phenylalanine-pyruvate transaminase activity
A	0048364	biological_process	root development
A	0048366	biological_process	leaf development
A	0048367	biological_process	shoot system development
A	0048467	biological_process	gynoecium development
A	0048825	biological_process	cotyledon development
A	0050048	molecular_function	obsolete L-leucine:2-oxoglutarate aminotransferase activity
A	0050362	molecular_function	L-tryptophan:2-oxoglutarate aminotransferase activity
A	0080022	biological_process	primary root development
A	0080097	molecular_function	L-tryptophan:pyruvate aminotransferase activity
A	0080098	molecular_function	L-tyrosine-pyruvate transaminase activity
A	0080099	molecular_function	L-methionine:2-oxoglutarate aminotransferase activity
A	0080100	molecular_function	obsolete L-glutamine:2-oxoglutarate aminotransferase activity
A	0080130	molecular_function	L-phenylalanine-2-oxoglutarate transaminase activity
B	0004021	molecular_function	L-alanine:2-oxoglutarate aminotransferase activity
B	0004838	molecular_function	L-tyrosine-2-oxoglutarate transaminase activity
B	0005515	molecular_function	protein binding
B	0005737	cellular_component	cytoplasm
B	0008483	molecular_function	transaminase activity
B	0009641	biological_process	shade avoidance
B	0009684	biological_process	indoleacetic acid biosynthetic process
B	0009723	biological_process	response to ethylene
B	0009793	biological_process	embryo development ending in seed dormancy
B	0009851	biological_process	auxin biosynthetic process
B	0009908	biological_process	flower development
B	0009926	biological_process	auxin polar transport
B	0009958	biological_process	positive gravitropism
B	0010078	biological_process	maintenance of root meristem identity
B	0010087	biological_process	phloem or xylem histogenesis
B	0010588	biological_process	cotyledon vascular tissue pattern formation
B	0016846	molecular_function	carbon-sulfur lyase activity
B	0030170	molecular_function	pyridoxal phosphate binding
B	0042742	biological_process	defense response to bacterium
B	0047312	molecular_function	L-phenylalanine-pyruvate transaminase activity
B	0048364	biological_process	root development
B	0048366	biological_process	leaf development
B	0048367	biological_process	shoot system development
B	0048467	biological_process	gynoecium development
B	0048825	biological_process	cotyledon development
B	0050048	molecular_function	obsolete L-leucine:2-oxoglutarate aminotransferase activity
B	0050362	molecular_function	L-tryptophan:2-oxoglutarate aminotransferase activity
B	0080022	biological_process	primary root development
B	0080097	molecular_function	L-tryptophan:pyruvate aminotransferase activity
B	0080098	molecular_function	L-tyrosine-pyruvate transaminase activity
B	0080099	molecular_function	L-methionine:2-oxoglutarate aminotransferase activity
B	0080100	molecular_function	obsolete L-glutamine:2-oxoglutarate aminotransferase activity
B	0080130	molecular_function	L-phenylalanine-2-oxoglutarate transaminase activity
C	0004021	molecular_function	L-alanine:2-oxoglutarate aminotransferase activity
C	0004838	molecular_function	L-tyrosine-2-oxoglutarate transaminase activity
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0008483	molecular_function	transaminase activity
C	0009641	biological_process	shade avoidance
C	0009684	biological_process	indoleacetic acid biosynthetic process
C	0009723	biological_process	response to ethylene
C	0009793	biological_process	embryo development ending in seed dormancy
C	0009851	biological_process	auxin biosynthetic process
C	0009908	biological_process	flower development
C	0009926	biological_process	auxin polar transport
C	0009958	biological_process	positive gravitropism
C	0010078	biological_process	maintenance of root meristem identity
C	0010087	biological_process	phloem or xylem histogenesis
C	0010588	biological_process	cotyledon vascular tissue pattern formation
C	0016846	molecular_function	carbon-sulfur lyase activity
C	0030170	molecular_function	pyridoxal phosphate binding
C	0042742	biological_process	defense response to bacterium
C	0047312	molecular_function	L-phenylalanine-pyruvate transaminase activity
C	0048364	biological_process	root development
C	0048366	biological_process	leaf development
C	0048367	biological_process	shoot system development
C	0048467	biological_process	gynoecium development
C	0048825	biological_process	cotyledon development
C	0050048	molecular_function	obsolete L-leucine:2-oxoglutarate aminotransferase activity
C	0050362	molecular_function	L-tryptophan:2-oxoglutarate aminotransferase activity
C	0080022	biological_process	primary root development
C	0080097	molecular_function	L-tryptophan:pyruvate aminotransferase activity
C	0080098	molecular_function	L-tyrosine-pyruvate transaminase activity
C	0080099	molecular_function	L-methionine:2-oxoglutarate aminotransferase activity
C	0080100	molecular_function	obsolete L-glutamine:2-oxoglutarate aminotransferase activity
C	0080130	molecular_function	L-phenylalanine-2-oxoglutarate transaminase activity
D	0004021	molecular_function	L-alanine:2-oxoglutarate aminotransferase activity
D	0004838	molecular_function	L-tyrosine-2-oxoglutarate transaminase activity
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0008483	molecular_function	transaminase activity
D	0009641	biological_process	shade avoidance
D	0009684	biological_process	indoleacetic acid biosynthetic process
D	0009723	biological_process	response to ethylene
D	0009793	biological_process	embryo development ending in seed dormancy
D	0009851	biological_process	auxin biosynthetic process
D	0009908	biological_process	flower development
D	0009926	biological_process	auxin polar transport
D	0009958	biological_process	positive gravitropism
D	0010078	biological_process	maintenance of root meristem identity
D	0010087	biological_process	phloem or xylem histogenesis
D	0010588	biological_process	cotyledon vascular tissue pattern formation
D	0016846	molecular_function	carbon-sulfur lyase activity
D	0030170	molecular_function	pyridoxal phosphate binding
D	0042742	biological_process	defense response to bacterium
D	0047312	molecular_function	L-phenylalanine-pyruvate transaminase activity
D	0048364	biological_process	root development
D	0048366	biological_process	leaf development
D	0048367	biological_process	shoot system development
D	0048467	biological_process	gynoecium development
D	0048825	biological_process	cotyledon development
D	0050048	molecular_function	obsolete L-leucine:2-oxoglutarate aminotransferase activity
D	0050362	molecular_function	L-tryptophan:2-oxoglutarate aminotransferase activity
D	0080022	biological_process	primary root development
D	0080097	molecular_function	L-tryptophan:pyruvate aminotransferase activity
D	0080098	molecular_function	L-tyrosine-pyruvate transaminase activity
D	0080099	molecular_function	L-methionine:2-oxoglutarate aminotransferase activity
D	0080100	molecular_function	obsolete L-glutamine:2-oxoglutarate aminotransferase activity
D	0080130	molecular_function	L-phenylalanine-2-oxoglutarate transaminase activity
E	0004021	molecular_function	L-alanine:2-oxoglutarate aminotransferase activity
E	0004838	molecular_function	L-tyrosine-2-oxoglutarate transaminase activity
E	0005515	molecular_function	protein binding
E	0005737	cellular_component	cytoplasm
E	0008483	molecular_function	transaminase activity
E	0009641	biological_process	shade avoidance
E	0009684	biological_process	indoleacetic acid biosynthetic process
E	0009723	biological_process	response to ethylene
E	0009793	biological_process	embryo development ending in seed dormancy
E	0009851	biological_process	auxin biosynthetic process
E	0009908	biological_process	flower development
E	0009926	biological_process	auxin polar transport
E	0009958	biological_process	positive gravitropism
E	0010078	biological_process	maintenance of root meristem identity
E	0010087	biological_process	phloem or xylem histogenesis
E	0010588	biological_process	cotyledon vascular tissue pattern formation
E	0016846	molecular_function	carbon-sulfur lyase activity
E	0030170	molecular_function	pyridoxal phosphate binding
E	0042742	biological_process	defense response to bacterium
E	0047312	molecular_function	L-phenylalanine-pyruvate transaminase activity
E	0048364	biological_process	root development
E	0048366	biological_process	leaf development
E	0048367	biological_process	shoot system development
E	0048467	biological_process	gynoecium development
E	0048825	biological_process	cotyledon development
E	0050048	molecular_function	obsolete L-leucine:2-oxoglutarate aminotransferase activity
E	0050362	molecular_function	L-tryptophan:2-oxoglutarate aminotransferase activity
E	0080022	biological_process	primary root development
E	0080097	molecular_function	L-tryptophan:pyruvate aminotransferase activity
E	0080098	molecular_function	L-tyrosine-pyruvate transaminase activity
E	0080099	molecular_function	L-methionine:2-oxoglutarate aminotransferase activity
E	0080100	molecular_function	obsolete L-glutamine:2-oxoglutarate aminotransferase activity
E	0080130	molecular_function	L-phenylalanine-2-oxoglutarate transaminase activity
F	0004021	molecular_function	L-alanine:2-oxoglutarate aminotransferase activity
F	0004838	molecular_function	L-tyrosine-2-oxoglutarate transaminase activity
F	0005515	molecular_function	protein binding
F	0005737	cellular_component	cytoplasm
F	0008483	molecular_function	transaminase activity
F	0009641	biological_process	shade avoidance
F	0009684	biological_process	indoleacetic acid biosynthetic process
F	0009723	biological_process	response to ethylene
F	0009793	biological_process	embryo development ending in seed dormancy
F	0009851	biological_process	auxin biosynthetic process
F	0009908	biological_process	flower development
F	0009926	biological_process	auxin polar transport
F	0009958	biological_process	positive gravitropism
F	0010078	biological_process	maintenance of root meristem identity
F	0010087	biological_process	phloem or xylem histogenesis
F	0010588	biological_process	cotyledon vascular tissue pattern formation
F	0016846	molecular_function	carbon-sulfur lyase activity
F	0030170	molecular_function	pyridoxal phosphate binding
F	0042742	biological_process	defense response to bacterium
F	0047312	molecular_function	L-phenylalanine-pyruvate transaminase activity
F	0048364	biological_process	root development
F	0048366	biological_process	leaf development
F	0048367	biological_process	shoot system development
F	0048467	biological_process	gynoecium development
F	0048825	biological_process	cotyledon development
F	0050048	molecular_function	obsolete L-leucine:2-oxoglutarate aminotransferase activity
F	0050362	molecular_function	L-tryptophan:2-oxoglutarate aminotransferase activity
F	0080022	biological_process	primary root development
F	0080097	molecular_function	L-tryptophan:pyruvate aminotransferase activity
F	0080098	molecular_function	L-tyrosine-pyruvate transaminase activity
F	0080099	molecular_function	L-methionine:2-oxoglutarate aminotransferase activity
F	0080100	molecular_function	obsolete L-glutamine:2-oxoglutarate aminotransferase activity
F	0080130	molecular_function	L-phenylalanine-2-oxoglutarate transaminase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE PO4 E 1001

Chain	Residue
E	GLY99
E	SER100
E	THR101
E	THR214
E	SER216
E	ARG225
F	TYR58
F	ILE249

site_id	AC2
Number of Residues	14
Details	BINDING SITE FOR RESIDUE PMP A 1001

Chain	Residue
A	SER100
A	THR101
A	TYR129
A	THR164
A	ASN168
A	ASP191
A	TYR194
A	THR214
A	SER216
A	LYS217
A	ARG225
B	TYR58
B	ILE249
A	GLY99

site_id	AC3
Number of Residues	13
Details	BINDING SITE FOR RESIDUE PMP B 1001

Chain	Residue
A	TYR58
A	ILE249
B	GLY99
B	SER100
B	THR101
B	THR164
B	ASN168
B	ASP191
B	TYR194
B	THR214
B	SER216
B	LYS217
B	ARG225

site_id	AC4
Number of Residues	14
Details	BINDING SITE FOR RESIDUE PMP D 1001

Chain	Residue
C	TYR58
C	ILE249
D	GLY99
D	SER100
D	THR101
D	TYR129
D	THR164
D	ASN168
D	ASP191
D	TYR194
D	THR214
D	SER216
D	LYS217
D	ARG225

site_id	AC5
Number of Residues	15
Details	BINDING SITE FOR RESIDUE PMP F 1001

Chain	Residue
E	TYR58
E	ILE249
F	GLY99
F	SER100
F	THR101
F	TYR129
F	THR164
F	ASN168
F	ASP191
F	TYR194
F	THR214
F	SER216
F	LYS217
F	ARG225
F	PHE2001

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE PHE F 2001

Chain	Residue
F	HIS29
F	GLY30
F	THR131
F	ASN168
F	LYS217
F	ARG350
F	ARG363

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	6
Details	BINDING: BINDING => ECO:0000269\|PubMed:18394996, ECO:0007744\|PDB:3BWN

Chain	Residue	Details
C	TYR58
B	ASP191
B	THR214
B	ARG225
D	TYR58
D	SER100
D	ASN168
D	ASP191
D	THR214
D	ARG225
E	TYR58
C	SER100
E	SER100
E	ASN168
E	ASP191
E	THR214
E	ARG225
F	TYR58
F	SER100
F	ASN168
F	ASP191
F	THR214
C	ASN168
F	ARG225
C	ASP191
C	THR214
C	ARG225
B	TYR58
B	SER100
B	ASN168

site_id	SWS_FT_FI2
Number of Residues	1
Details	MOD_RES: N6-(pyridoxal phosphate)lysine => ECO:0000255

Chain	Residue	Details
C	LLP217
B	LYS217
D	LYS217
E	LYS217
F	LYS217

Catalytic Information from CSA

site_id	CSA1
Number of Residues	3
Details	Annotated By Reference To The Literature 1ay4

Chain	Residue	Details
A	TYR129
A	ASP191
A	LYS217

site_id	CSA10
Number of Residues	3
Details	Annotated By Reference To The Literature 1ay4

Chain	Residue	Details
E	ASP191
E	TYR93
E	LYS217

site_id	CSA11
Number of Residues	3
Details	Annotated By Reference To The Literature 1ay4

Chain	Residue	Details
F	ASP191
F	TYR93
F	LYS217

site_id	CSA12
Number of Residues	2
Details	Annotated By Reference To The Literature 1ay4

Chain	Residue	Details
C	ASP191
C	TYR93

site_id	CSA2
Number of Residues	3
Details	Annotated By Reference To The Literature 1ay4

Chain	Residue	Details
B	TYR129
B	ASP191
B	LYS217

site_id	CSA3
Number of Residues	3
Details	Annotated By Reference To The Literature 1ay4

Chain	Residue	Details
D	TYR129
D	ASP191
D	LYS217

site_id	CSA4
Number of Residues	3
Details	Annotated By Reference To The Literature 1ay4

Chain	Residue	Details
E	TYR129
E	ASP191
E	LYS217

site_id	CSA5
Number of Residues	3
Details	Annotated By Reference To The Literature 1ay4

Chain	Residue	Details
F	TYR129
F	ASP191
F	LYS217

site_id	CSA6
Number of Residues	2
Details	Annotated By Reference To The Literature 1ay4

Chain	Residue	Details
C	TYR129
C	ASP191

site_id	CSA7
Number of Residues	3
Details	Annotated By Reference To The Literature 1ay4

Chain	Residue	Details
A	ASP191
A	TYR93
A	LYS217

site_id	CSA8
Number of Residues	3
Details	Annotated By Reference To The Literature 1ay4

Chain	Residue	Details
B	ASP191
B	TYR93
B	LYS217

site_id	CSA9
Number of Residues	3
Details	Annotated By Reference To The Literature 1ay4

Chain	Residue	Details
D	ASP191
D	TYR93
D	LYS217

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)