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3BWE

Crystal structure of aggregated form of DJ1

Functional Information from GO Data
ChainGOidnamespacecontents
A0000785cellular_componentchromatin
A0001046molecular_functioncore promoter sequence-specific DNA binding
A0001933biological_processnegative regulation of protein phosphorylation
A0001963biological_processsynaptic transmission, dopaminergic
A0002866biological_processpositive regulation of acute inflammatory response to antigenic stimulus
A0003690molecular_functiondouble-stranded DNA binding
A0003697molecular_functionsingle-stranded DNA binding
A0003713molecular_functiontranscription coactivator activity
A0003723molecular_functionRNA binding
A0003729molecular_functionmRNA binding
A0005102molecular_functionsignaling receptor binding
A0005507molecular_functioncopper ion binding
A0005515molecular_functionprotein binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005758cellular_componentmitochondrial intermembrane space
A0005759cellular_componentmitochondrial matrix
A0005783cellular_componentendoplasmic reticulum
A0005829cellular_componentcytosol
A0005886cellular_componentplasma membrane
A0005912cellular_componentadherens junction
A0006281biological_processDNA repair
A0006508biological_processproteolysis
A0006914biological_processautophagy
A0006954biological_processinflammatory response
A0006979biological_processresponse to oxidative stress
A0007005biological_processmitochondrion organization
A0007265biological_processRas protein signal transduction
A0007338biological_processsingle fertilization
A0008021cellular_componentsynaptic vesicle
A0008047molecular_functionenzyme activator activity
A0008233molecular_functionpeptidase activity
A0008344biological_processadult locomotory behavior
A0009438biological_processmethylglyoxal metabolic process
A0010273biological_processdetoxification of copper ion
A0010628biological_processpositive regulation of gene expression
A0010629biological_processnegative regulation of gene expression
A0016532molecular_functionsuperoxide dismutase copper chaperone activity
A0016605cellular_componentPML body
A0016684molecular_functionoxidoreductase activity, acting on peroxide as acceptor
A0019249biological_processlactate biosynthetic process
A0019430biological_processremoval of superoxide radicals
A0019826molecular_functionoxygen sensor activity
A0019899molecular_functionenzyme binding
A0019900molecular_functionkinase binding
A0019955molecular_functioncytokine binding
A0030073biological_processinsulin secretion
A0030091biological_processprotein repair
A0030414molecular_functionpeptidase inhibitor activity
A0030424cellular_componentaxon
A0030521biological_processandrogen receptor signaling pathway
A0030546molecular_functionsignaling receptor activator activity
A0031334biological_processpositive regulation of protein-containing complex assembly
A0031397biological_processnegative regulation of protein ubiquitination
A0032435biological_processnegative regulation of proteasomal ubiquitin-dependent protein catabolic process
A0032679biological_processregulation of TRAIL production
A0032757biological_processpositive regulation of interleukin-8 production
A0033138biological_processpositive regulation of peptidyl-serine phosphorylation
A0033234biological_processnegative regulation of protein sumoylation
A0033864biological_processpositive regulation of NAD(P)H oxidase activity
A0034599biological_processcellular response to oxidative stress
A0034614biological_processcellular response to reactive oxygen species
A0036470molecular_functiontyrosine 3-monooxygenase activator activity
A0036471biological_processcellular response to glyoxal
A0036478molecular_functionL-dopa decarboxylase activator activity
A0036524molecular_functionprotein deglycase activity
A0042177biological_processnegative regulation of protein catabolic process
A0042542biological_processresponse to hydrogen peroxide
A0042593biological_processglucose homeostasis
A0042743biological_processhydrogen peroxide metabolic process
A0042802molecular_functionidentical protein binding
A0042803molecular_functionprotein homodimerization activity
A0043005cellular_componentneuron projection
A0043523biological_processregulation of neuron apoptotic process
A0043524biological_processnegative regulation of neuron apoptotic process
A0044297cellular_componentcell body
A0044388molecular_functionsmall protein activating enzyme binding
A0044390molecular_functionubiquitin-like protein conjugating enzyme binding
A0045121cellular_componentmembrane raft
A0045296molecular_functioncadherin binding
A0045340molecular_functionmercury ion binding
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0046295biological_processglycolate biosynthetic process
A0046826biological_processnegative regulation of protein export from nucleus
A0048471cellular_componentperinuclear region of cytoplasm
A0050681molecular_functionnuclear androgen receptor binding
A0050727biological_processregulation of inflammatory response
A0050787biological_processdetoxification of mercury ion
A0050821biological_processprotein stabilization
A0051583biological_processdopamine uptake involved in synaptic transmission
A0051881biological_processregulation of mitochondrial membrane potential
A0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
A0051899biological_processmembrane depolarization
A0051920molecular_functionperoxiredoxin activity
A0055105molecular_functionubiquitin-protein transferase inhibitor activity
A0060081biological_processmembrane hyperpolarization
A0060765biological_processregulation of androgen receptor signaling pathway
A0061691biological_processdetoxification of hydrogen peroxide
A0061727biological_processmethylglyoxal catabolic process to lactate
A0070062cellular_componentextracellular exosome
A0070301biological_processcellular response to hydrogen peroxide
A0070994biological_processdetection of oxidative stress
A0097110molecular_functionscaffold protein binding
A0106044biological_processguanine deglycation
A0106045biological_processguanine deglycation, methylglyoxal removal
A0106046biological_processguanine deglycation, glyoxal removal
A0110095biological_processcellular detoxification of aldehyde
A0140041biological_processcellular detoxification of methylglyoxal
A0140297molecular_functionDNA-binding transcription factor binding
A1900182biological_processpositive regulation of protein localization to nucleus
A1900242biological_processregulation of synaptic vesicle endocytosis
A1901984biological_processnegative regulation of protein acetylation
A1902176biological_processnegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
A1902177biological_processpositive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
A1902236biological_processnegative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
A1902903biological_processregulation of supramolecular fiber organization
A1902958biological_processpositive regulation of mitochondrial electron transport, NADH to ubiquinone
A1903073biological_processnegative regulation of death-inducing signaling complex assembly
A1903094biological_processnegative regulation of protein K48-linked deubiquitination
A1903122biological_processnegative regulation of TRAIL-activated apoptotic signaling pathway
A1903135molecular_functioncupric ion binding
A1903136molecular_functioncuprous ion binding
A1903181biological_processpositive regulation of dopamine biosynthetic process
A1903189biological_processglyoxal metabolic process
A1903190biological_processglyoxal catabolic process
A1903197biological_processpositive regulation of L-dopa biosynthetic process
A1903376biological_processregulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
A1903377biological_processnegative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
A1903384biological_processnegative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway
A1903427biological_processnegative regulation of reactive oxygen species biosynthetic process
A1903428biological_processpositive regulation of reactive oxygen species biosynthetic process
A1903599biological_processpositive regulation of autophagy of mitochondrion
A1903751biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide
A1905259biological_processnegative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway
A1990381molecular_functionubiquitin-specific protease binding
A1990422molecular_functionglyoxalase (glycolic acid-forming) activity
A2000277biological_processpositive regulation of oxidative phosphorylation uncoupler activity
A2000379biological_processpositive regulation of reactive oxygen species metabolic process
A2001237biological_processnegative regulation of extrinsic apoptotic signaling pathway
B0000785cellular_componentchromatin
B0001046molecular_functioncore promoter sequence-specific DNA binding
B0001933biological_processnegative regulation of protein phosphorylation
B0001963biological_processsynaptic transmission, dopaminergic
B0002866biological_processpositive regulation of acute inflammatory response to antigenic stimulus
B0003690molecular_functiondouble-stranded DNA binding
B0003697molecular_functionsingle-stranded DNA binding
B0003713molecular_functiontranscription coactivator activity
B0003723molecular_functionRNA binding
B0003729molecular_functionmRNA binding
B0005102molecular_functionsignaling receptor binding
B0005507molecular_functioncopper ion binding
B0005515molecular_functionprotein binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005758cellular_componentmitochondrial intermembrane space
B0005759cellular_componentmitochondrial matrix
B0005783cellular_componentendoplasmic reticulum
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0005912cellular_componentadherens junction
B0006281biological_processDNA repair
B0006508biological_processproteolysis
B0006914biological_processautophagy
B0006954biological_processinflammatory response
B0006979biological_processresponse to oxidative stress
B0007005biological_processmitochondrion organization
B0007265biological_processRas protein signal transduction
B0007338biological_processsingle fertilization
B0008021cellular_componentsynaptic vesicle
B0008047molecular_functionenzyme activator activity
B0008233molecular_functionpeptidase activity
B0008344biological_processadult locomotory behavior
B0009438biological_processmethylglyoxal metabolic process
B0010273biological_processdetoxification of copper ion
B0010628biological_processpositive regulation of gene expression
B0010629biological_processnegative regulation of gene expression
B0016532molecular_functionsuperoxide dismutase copper chaperone activity
B0016605cellular_componentPML body
B0016684molecular_functionoxidoreductase activity, acting on peroxide as acceptor
B0019249biological_processlactate biosynthetic process
B0019430biological_processremoval of superoxide radicals
B0019826molecular_functionoxygen sensor activity
B0019899molecular_functionenzyme binding
B0019900molecular_functionkinase binding
B0019955molecular_functioncytokine binding
B0030073biological_processinsulin secretion
B0030091biological_processprotein repair
B0030414molecular_functionpeptidase inhibitor activity
B0030424cellular_componentaxon
B0030521biological_processandrogen receptor signaling pathway
B0030546molecular_functionsignaling receptor activator activity
B0031334biological_processpositive regulation of protein-containing complex assembly
B0031397biological_processnegative regulation of protein ubiquitination
B0032435biological_processnegative regulation of proteasomal ubiquitin-dependent protein catabolic process
B0032679biological_processregulation of TRAIL production
B0032757biological_processpositive regulation of interleukin-8 production
B0033138biological_processpositive regulation of peptidyl-serine phosphorylation
B0033234biological_processnegative regulation of protein sumoylation
B0033864biological_processpositive regulation of NAD(P)H oxidase activity
B0034599biological_processcellular response to oxidative stress
B0034614biological_processcellular response to reactive oxygen species
B0036470molecular_functiontyrosine 3-monooxygenase activator activity
B0036471biological_processcellular response to glyoxal
B0036478molecular_functionL-dopa decarboxylase activator activity
B0036524molecular_functionprotein deglycase activity
B0042177biological_processnegative regulation of protein catabolic process
B0042542biological_processresponse to hydrogen peroxide
B0042593biological_processglucose homeostasis
B0042743biological_processhydrogen peroxide metabolic process
B0042802molecular_functionidentical protein binding
B0042803molecular_functionprotein homodimerization activity
B0043005cellular_componentneuron projection
B0043523biological_processregulation of neuron apoptotic process
B0043524biological_processnegative regulation of neuron apoptotic process
B0044297cellular_componentcell body
B0044388molecular_functionsmall protein activating enzyme binding
B0044390molecular_functionubiquitin-like protein conjugating enzyme binding
B0045121cellular_componentmembrane raft
B0045296molecular_functioncadherin binding
B0045340molecular_functionmercury ion binding
B0045944biological_processpositive regulation of transcription by RNA polymerase II
B0046295biological_processglycolate biosynthetic process
B0046826biological_processnegative regulation of protein export from nucleus
B0048471cellular_componentperinuclear region of cytoplasm
B0050681molecular_functionnuclear androgen receptor binding
B0050727biological_processregulation of inflammatory response
B0050787biological_processdetoxification of mercury ion
B0050821biological_processprotein stabilization
B0051583biological_processdopamine uptake involved in synaptic transmission
B0051881biological_processregulation of mitochondrial membrane potential
B0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
B0051899biological_processmembrane depolarization
B0051920molecular_functionperoxiredoxin activity
B0055105molecular_functionubiquitin-protein transferase inhibitor activity
B0060081biological_processmembrane hyperpolarization
B0060765biological_processregulation of androgen receptor signaling pathway
B0061691biological_processdetoxification of hydrogen peroxide
B0061727biological_processmethylglyoxal catabolic process to lactate
B0070062cellular_componentextracellular exosome
B0070301biological_processcellular response to hydrogen peroxide
B0070994biological_processdetection of oxidative stress
B0097110molecular_functionscaffold protein binding
B0106044biological_processguanine deglycation
B0106045biological_processguanine deglycation, methylglyoxal removal
B0106046biological_processguanine deglycation, glyoxal removal
B0110095biological_processcellular detoxification of aldehyde
B0140041biological_processcellular detoxification of methylglyoxal
B0140297molecular_functionDNA-binding transcription factor binding
B1900182biological_processpositive regulation of protein localization to nucleus
B1900242biological_processregulation of synaptic vesicle endocytosis
B1901984biological_processnegative regulation of protein acetylation
B1902176biological_processnegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
B1902177biological_processpositive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
B1902236biological_processnegative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
B1902903biological_processregulation of supramolecular fiber organization
B1902958biological_processpositive regulation of mitochondrial electron transport, NADH to ubiquinone
B1903073biological_processnegative regulation of death-inducing signaling complex assembly
B1903094biological_processnegative regulation of protein K48-linked deubiquitination
B1903122biological_processnegative regulation of TRAIL-activated apoptotic signaling pathway
B1903135molecular_functioncupric ion binding
B1903136molecular_functioncuprous ion binding
B1903181biological_processpositive regulation of dopamine biosynthetic process
B1903189biological_processglyoxal metabolic process
B1903190biological_processglyoxal catabolic process
B1903197biological_processpositive regulation of L-dopa biosynthetic process
B1903376biological_processregulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
B1903377biological_processnegative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
B1903384biological_processnegative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway
B1903427biological_processnegative regulation of reactive oxygen species biosynthetic process
B1903428biological_processpositive regulation of reactive oxygen species biosynthetic process
B1903599biological_processpositive regulation of autophagy of mitochondrion
B1903751biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide
B1905259biological_processnegative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway
B1990381molecular_functionubiquitin-specific protease binding
B1990422molecular_functionglyoxalase (glycolic acid-forming) activity
B2000277biological_processpositive regulation of oxidative phosphorylation uncoupler activity
B2000379biological_processpositive regulation of reactive oxygen species metabolic process
B2001237biological_processnegative regulation of extrinsic apoptotic signaling pathway
C0000785cellular_componentchromatin
C0001046molecular_functioncore promoter sequence-specific DNA binding
C0001933biological_processnegative regulation of protein phosphorylation
C0001963biological_processsynaptic transmission, dopaminergic
C0002866biological_processpositive regulation of acute inflammatory response to antigenic stimulus
C0003690molecular_functiondouble-stranded DNA binding
C0003697molecular_functionsingle-stranded DNA binding
C0003713molecular_functiontranscription coactivator activity
C0003723molecular_functionRNA binding
C0003729molecular_functionmRNA binding
C0005102molecular_functionsignaling receptor binding
C0005507molecular_functioncopper ion binding
C0005515molecular_functionprotein binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005739cellular_componentmitochondrion
C0005758cellular_componentmitochondrial intermembrane space
C0005759cellular_componentmitochondrial matrix
C0005783cellular_componentendoplasmic reticulum
C0005829cellular_componentcytosol
C0005886cellular_componentplasma membrane
C0005912cellular_componentadherens junction
C0006281biological_processDNA repair
C0006508biological_processproteolysis
C0006914biological_processautophagy
C0006954biological_processinflammatory response
C0006979biological_processresponse to oxidative stress
C0007005biological_processmitochondrion organization
C0007265biological_processRas protein signal transduction
C0007338biological_processsingle fertilization
C0008021cellular_componentsynaptic vesicle
C0008047molecular_functionenzyme activator activity
C0008233molecular_functionpeptidase activity
C0008344biological_processadult locomotory behavior
C0009438biological_processmethylglyoxal metabolic process
C0010273biological_processdetoxification of copper ion
C0010628biological_processpositive regulation of gene expression
C0010629biological_processnegative regulation of gene expression
C0016532molecular_functionsuperoxide dismutase copper chaperone activity
C0016605cellular_componentPML body
C0016684molecular_functionoxidoreductase activity, acting on peroxide as acceptor
C0019249biological_processlactate biosynthetic process
C0019430biological_processremoval of superoxide radicals
C0019826molecular_functionoxygen sensor activity
C0019899molecular_functionenzyme binding
C0019900molecular_functionkinase binding
C0019955molecular_functioncytokine binding
C0030073biological_processinsulin secretion
C0030091biological_processprotein repair
C0030414molecular_functionpeptidase inhibitor activity
C0030424cellular_componentaxon
C0030521biological_processandrogen receptor signaling pathway
C0030546molecular_functionsignaling receptor activator activity
C0031334biological_processpositive regulation of protein-containing complex assembly
C0031397biological_processnegative regulation of protein ubiquitination
C0032435biological_processnegative regulation of proteasomal ubiquitin-dependent protein catabolic process
C0032679biological_processregulation of TRAIL production
C0032757biological_processpositive regulation of interleukin-8 production
C0033138biological_processpositive regulation of peptidyl-serine phosphorylation
C0033234biological_processnegative regulation of protein sumoylation
C0033864biological_processpositive regulation of NAD(P)H oxidase activity
C0034599biological_processcellular response to oxidative stress
C0034614biological_processcellular response to reactive oxygen species
C0036470molecular_functiontyrosine 3-monooxygenase activator activity
C0036471biological_processcellular response to glyoxal
C0036478molecular_functionL-dopa decarboxylase activator activity
C0036524molecular_functionprotein deglycase activity
C0042177biological_processnegative regulation of protein catabolic process
C0042542biological_processresponse to hydrogen peroxide
C0042593biological_processglucose homeostasis
C0042743biological_processhydrogen peroxide metabolic process
C0042802molecular_functionidentical protein binding
C0042803molecular_functionprotein homodimerization activity
C0043005cellular_componentneuron projection
C0043523biological_processregulation of neuron apoptotic process
C0043524biological_processnegative regulation of neuron apoptotic process
C0044297cellular_componentcell body
C0044388molecular_functionsmall protein activating enzyme binding
C0044390molecular_functionubiquitin-like protein conjugating enzyme binding
C0045121cellular_componentmembrane raft
C0045296molecular_functioncadherin binding
C0045340molecular_functionmercury ion binding
C0045944biological_processpositive regulation of transcription by RNA polymerase II
C0046295biological_processglycolate biosynthetic process
C0046826biological_processnegative regulation of protein export from nucleus
C0048471cellular_componentperinuclear region of cytoplasm
C0050681molecular_functionnuclear androgen receptor binding
C0050727biological_processregulation of inflammatory response
C0050787biological_processdetoxification of mercury ion
C0050821biological_processprotein stabilization
C0051583biological_processdopamine uptake involved in synaptic transmission
C0051881biological_processregulation of mitochondrial membrane potential
C0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
C0051899biological_processmembrane depolarization
C0051920molecular_functionperoxiredoxin activity
C0055105molecular_functionubiquitin-protein transferase inhibitor activity
C0060081biological_processmembrane hyperpolarization
C0060765biological_processregulation of androgen receptor signaling pathway
C0061691biological_processdetoxification of hydrogen peroxide
C0061727biological_processmethylglyoxal catabolic process to lactate
C0070062cellular_componentextracellular exosome
C0070301biological_processcellular response to hydrogen peroxide
C0070994biological_processdetection of oxidative stress
C0097110molecular_functionscaffold protein binding
C0106044biological_processguanine deglycation
C0106045biological_processguanine deglycation, methylglyoxal removal
C0106046biological_processguanine deglycation, glyoxal removal
C0110095biological_processcellular detoxification of aldehyde
C0140041biological_processcellular detoxification of methylglyoxal
C0140297molecular_functionDNA-binding transcription factor binding
C1900182biological_processpositive regulation of protein localization to nucleus
C1900242biological_processregulation of synaptic vesicle endocytosis
C1901984biological_processnegative regulation of protein acetylation
C1902176biological_processnegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
C1902177biological_processpositive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
C1902236biological_processnegative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
C1902903biological_processregulation of supramolecular fiber organization
C1902958biological_processpositive regulation of mitochondrial electron transport, NADH to ubiquinone
C1903073biological_processnegative regulation of death-inducing signaling complex assembly
C1903094biological_processnegative regulation of protein K48-linked deubiquitination
C1903122biological_processnegative regulation of TRAIL-activated apoptotic signaling pathway
C1903135molecular_functioncupric ion binding
C1903136molecular_functioncuprous ion binding
C1903181biological_processpositive regulation of dopamine biosynthetic process
C1903189biological_processglyoxal metabolic process
C1903190biological_processglyoxal catabolic process
C1903197biological_processpositive regulation of L-dopa biosynthetic process
C1903376biological_processregulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
C1903377biological_processnegative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
C1903384biological_processnegative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway
C1903427biological_processnegative regulation of reactive oxygen species biosynthetic process
C1903428biological_processpositive regulation of reactive oxygen species biosynthetic process
C1903599biological_processpositive regulation of autophagy of mitochondrion
C1903751biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide
C1905259biological_processnegative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway
C1990381molecular_functionubiquitin-specific protease binding
C1990422molecular_functionglyoxalase (glycolic acid-forming) activity
C2000277biological_processpositive regulation of oxidative phosphorylation uncoupler activity
C2000379biological_processpositive regulation of reactive oxygen species metabolic process
C2001237biological_processnegative regulation of extrinsic apoptotic signaling pathway
D0000785cellular_componentchromatin
D0001046molecular_functioncore promoter sequence-specific DNA binding
D0001933biological_processnegative regulation of protein phosphorylation
D0001963biological_processsynaptic transmission, dopaminergic
D0002866biological_processpositive regulation of acute inflammatory response to antigenic stimulus
D0003690molecular_functiondouble-stranded DNA binding
D0003697molecular_functionsingle-stranded DNA binding
D0003713molecular_functiontranscription coactivator activity
D0003723molecular_functionRNA binding
D0003729molecular_functionmRNA binding
D0005102molecular_functionsignaling receptor binding
D0005507molecular_functioncopper ion binding
D0005515molecular_functionprotein binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005739cellular_componentmitochondrion
D0005758cellular_componentmitochondrial intermembrane space
D0005759cellular_componentmitochondrial matrix
D0005783cellular_componentendoplasmic reticulum
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0005912cellular_componentadherens junction
D0006281biological_processDNA repair
D0006508biological_processproteolysis
D0006914biological_processautophagy
D0006954biological_processinflammatory response
D0006979biological_processresponse to oxidative stress
D0007005biological_processmitochondrion organization
D0007265biological_processRas protein signal transduction
D0007338biological_processsingle fertilization
D0008021cellular_componentsynaptic vesicle
D0008047molecular_functionenzyme activator activity
D0008233molecular_functionpeptidase activity
D0008344biological_processadult locomotory behavior
D0009438biological_processmethylglyoxal metabolic process
D0010273biological_processdetoxification of copper ion
D0010628biological_processpositive regulation of gene expression
D0010629biological_processnegative regulation of gene expression
D0016532molecular_functionsuperoxide dismutase copper chaperone activity
D0016605cellular_componentPML body
D0016684molecular_functionoxidoreductase activity, acting on peroxide as acceptor
D0019249biological_processlactate biosynthetic process
D0019430biological_processremoval of superoxide radicals
D0019826molecular_functionoxygen sensor activity
D0019899molecular_functionenzyme binding
D0019900molecular_functionkinase binding
D0019955molecular_functioncytokine binding
D0030073biological_processinsulin secretion
D0030091biological_processprotein repair
D0030414molecular_functionpeptidase inhibitor activity
D0030424cellular_componentaxon
D0030521biological_processandrogen receptor signaling pathway
D0030546molecular_functionsignaling receptor activator activity
D0031334biological_processpositive regulation of protein-containing complex assembly
D0031397biological_processnegative regulation of protein ubiquitination
D0032435biological_processnegative regulation of proteasomal ubiquitin-dependent protein catabolic process
D0032679biological_processregulation of TRAIL production
D0032757biological_processpositive regulation of interleukin-8 production
D0033138biological_processpositive regulation of peptidyl-serine phosphorylation
D0033234biological_processnegative regulation of protein sumoylation
D0033864biological_processpositive regulation of NAD(P)H oxidase activity
D0034599biological_processcellular response to oxidative stress
D0034614biological_processcellular response to reactive oxygen species
D0036470molecular_functiontyrosine 3-monooxygenase activator activity
D0036471biological_processcellular response to glyoxal
D0036478molecular_functionL-dopa decarboxylase activator activity
D0036524molecular_functionprotein deglycase activity
D0042177biological_processnegative regulation of protein catabolic process
D0042542biological_processresponse to hydrogen peroxide
D0042593biological_processglucose homeostasis
D0042743biological_processhydrogen peroxide metabolic process
D0042802molecular_functionidentical protein binding
D0042803molecular_functionprotein homodimerization activity
D0043005cellular_componentneuron projection
D0043523biological_processregulation of neuron apoptotic process
D0043524biological_processnegative regulation of neuron apoptotic process
D0044297cellular_componentcell body
D0044388molecular_functionsmall protein activating enzyme binding
D0044390molecular_functionubiquitin-like protein conjugating enzyme binding
D0045121cellular_componentmembrane raft
D0045296molecular_functioncadherin binding
D0045340molecular_functionmercury ion binding
D0045944biological_processpositive regulation of transcription by RNA polymerase II
D0046295biological_processglycolate biosynthetic process
D0046826biological_processnegative regulation of protein export from nucleus
D0048471cellular_componentperinuclear region of cytoplasm
D0050681molecular_functionnuclear androgen receptor binding
D0050727biological_processregulation of inflammatory response
D0050787biological_processdetoxification of mercury ion
D0050821biological_processprotein stabilization
D0051583biological_processdopamine uptake involved in synaptic transmission
D0051881biological_processregulation of mitochondrial membrane potential
D0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
D0051899biological_processmembrane depolarization
D0051920molecular_functionperoxiredoxin activity
D0055105molecular_functionubiquitin-protein transferase inhibitor activity
D0060081biological_processmembrane hyperpolarization
D0060765biological_processregulation of androgen receptor signaling pathway
D0061691biological_processdetoxification of hydrogen peroxide
D0061727biological_processmethylglyoxal catabolic process to lactate
D0070062cellular_componentextracellular exosome
D0070301biological_processcellular response to hydrogen peroxide
D0070994biological_processdetection of oxidative stress
D0097110molecular_functionscaffold protein binding
D0106044biological_processguanine deglycation
D0106045biological_processguanine deglycation, methylglyoxal removal
D0106046biological_processguanine deglycation, glyoxal removal
D0110095biological_processcellular detoxification of aldehyde
D0140041biological_processcellular detoxification of methylglyoxal
D0140297molecular_functionDNA-binding transcription factor binding
D1900182biological_processpositive regulation of protein localization to nucleus
D1900242biological_processregulation of synaptic vesicle endocytosis
D1901984biological_processnegative regulation of protein acetylation
D1902176biological_processnegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
D1902177biological_processpositive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
D1902236biological_processnegative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
D1902903biological_processregulation of supramolecular fiber organization
D1902958biological_processpositive regulation of mitochondrial electron transport, NADH to ubiquinone
D1903073biological_processnegative regulation of death-inducing signaling complex assembly
D1903094biological_processnegative regulation of protein K48-linked deubiquitination
D1903122biological_processnegative regulation of TRAIL-activated apoptotic signaling pathway
D1903135molecular_functioncupric ion binding
D1903136molecular_functioncuprous ion binding
D1903181biological_processpositive regulation of dopamine biosynthetic process
D1903189biological_processglyoxal metabolic process
D1903190biological_processglyoxal catabolic process
D1903197biological_processpositive regulation of L-dopa biosynthetic process
D1903376biological_processregulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
D1903377biological_processnegative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
D1903384biological_processnegative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway
D1903427biological_processnegative regulation of reactive oxygen species biosynthetic process
D1903428biological_processpositive regulation of reactive oxygen species biosynthetic process
D1903599biological_processpositive regulation of autophagy of mitochondrion
D1903751biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide
D1905259biological_processnegative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway
D1990381molecular_functionubiquitin-specific protease binding
D1990422molecular_functionglyoxalase (glycolic acid-forming) activity
D2000277biological_processpositive regulation of oxidative phosphorylation uncoupler activity
D2000379biological_processpositive regulation of reactive oxygen species metabolic process
D2001237biological_processnegative regulation of extrinsic apoptotic signaling pathway
E0000785cellular_componentchromatin
E0001046molecular_functioncore promoter sequence-specific DNA binding
E0001933biological_processnegative regulation of protein phosphorylation
E0001963biological_processsynaptic transmission, dopaminergic
E0002866biological_processpositive regulation of acute inflammatory response to antigenic stimulus
E0003690molecular_functiondouble-stranded DNA binding
E0003697molecular_functionsingle-stranded DNA binding
E0003713molecular_functiontranscription coactivator activity
E0003723molecular_functionRNA binding
E0003729molecular_functionmRNA binding
E0005102molecular_functionsignaling receptor binding
E0005507molecular_functioncopper ion binding
E0005515molecular_functionprotein binding
E0005634cellular_componentnucleus
E0005654cellular_componentnucleoplasm
E0005737cellular_componentcytoplasm
E0005739cellular_componentmitochondrion
E0005758cellular_componentmitochondrial intermembrane space
E0005759cellular_componentmitochondrial matrix
E0005783cellular_componentendoplasmic reticulum
E0005829cellular_componentcytosol
E0005886cellular_componentplasma membrane
E0005912cellular_componentadherens junction
E0006281biological_processDNA repair
E0006508biological_processproteolysis
E0006914biological_processautophagy
E0006954biological_processinflammatory response
E0006979biological_processresponse to oxidative stress
E0007005biological_processmitochondrion organization
E0007265biological_processRas protein signal transduction
E0007338biological_processsingle fertilization
E0008021cellular_componentsynaptic vesicle
E0008047molecular_functionenzyme activator activity
E0008233molecular_functionpeptidase activity
E0008344biological_processadult locomotory behavior
E0009438biological_processmethylglyoxal metabolic process
E0010273biological_processdetoxification of copper ion
E0010628biological_processpositive regulation of gene expression
E0010629biological_processnegative regulation of gene expression
E0016532molecular_functionsuperoxide dismutase copper chaperone activity
E0016605cellular_componentPML body
E0016684molecular_functionoxidoreductase activity, acting on peroxide as acceptor
E0019249biological_processlactate biosynthetic process
E0019430biological_processremoval of superoxide radicals
E0019826molecular_functionoxygen sensor activity
E0019899molecular_functionenzyme binding
E0019900molecular_functionkinase binding
E0019955molecular_functioncytokine binding
E0030073biological_processinsulin secretion
E0030091biological_processprotein repair
E0030414molecular_functionpeptidase inhibitor activity
E0030424cellular_componentaxon
E0030521biological_processandrogen receptor signaling pathway
E0030546molecular_functionsignaling receptor activator activity
E0031334biological_processpositive regulation of protein-containing complex assembly
E0031397biological_processnegative regulation of protein ubiquitination
E0032435biological_processnegative regulation of proteasomal ubiquitin-dependent protein catabolic process
E0032679biological_processregulation of TRAIL production
E0032757biological_processpositive regulation of interleukin-8 production
E0033138biological_processpositive regulation of peptidyl-serine phosphorylation
E0033234biological_processnegative regulation of protein sumoylation
E0033864biological_processpositive regulation of NAD(P)H oxidase activity
E0034599biological_processcellular response to oxidative stress
E0034614biological_processcellular response to reactive oxygen species
E0036470molecular_functiontyrosine 3-monooxygenase activator activity
E0036471biological_processcellular response to glyoxal
E0036478molecular_functionL-dopa decarboxylase activator activity
E0036524molecular_functionprotein deglycase activity
E0042177biological_processnegative regulation of protein catabolic process
E0042542biological_processresponse to hydrogen peroxide
E0042593biological_processglucose homeostasis
E0042743biological_processhydrogen peroxide metabolic process
E0042802molecular_functionidentical protein binding
E0042803molecular_functionprotein homodimerization activity
E0043005cellular_componentneuron projection
E0043523biological_processregulation of neuron apoptotic process
E0043524biological_processnegative regulation of neuron apoptotic process
E0044297cellular_componentcell body
E0044388molecular_functionsmall protein activating enzyme binding
E0044390molecular_functionubiquitin-like protein conjugating enzyme binding
E0045121cellular_componentmembrane raft
E0045296molecular_functioncadherin binding
E0045340molecular_functionmercury ion binding
E0045944biological_processpositive regulation of transcription by RNA polymerase II
E0046295biological_processglycolate biosynthetic process
E0046826biological_processnegative regulation of protein export from nucleus
E0048471cellular_componentperinuclear region of cytoplasm
E0050681molecular_functionnuclear androgen receptor binding
E0050727biological_processregulation of inflammatory response
E0050787biological_processdetoxification of mercury ion
E0050821biological_processprotein stabilization
E0051583biological_processdopamine uptake involved in synaptic transmission
E0051881biological_processregulation of mitochondrial membrane potential
E0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
E0051899biological_processmembrane depolarization
E0051920molecular_functionperoxiredoxin activity
E0055105molecular_functionubiquitin-protein transferase inhibitor activity
E0060081biological_processmembrane hyperpolarization
E0060765biological_processregulation of androgen receptor signaling pathway
E0061691biological_processdetoxification of hydrogen peroxide
E0061727biological_processmethylglyoxal catabolic process to lactate
E0070062cellular_componentextracellular exosome
E0070301biological_processcellular response to hydrogen peroxide
E0070994biological_processdetection of oxidative stress
E0097110molecular_functionscaffold protein binding
E0106044biological_processguanine deglycation
E0106045biological_processguanine deglycation, methylglyoxal removal
E0106046biological_processguanine deglycation, glyoxal removal
E0110095biological_processcellular detoxification of aldehyde
E0140041biological_processcellular detoxification of methylglyoxal
E0140297molecular_functionDNA-binding transcription factor binding
E1900182biological_processpositive regulation of protein localization to nucleus
E1900242biological_processregulation of synaptic vesicle endocytosis
E1901984biological_processnegative regulation of protein acetylation
E1902176biological_processnegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
E1902177biological_processpositive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
E1902236biological_processnegative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
E1902903biological_processregulation of supramolecular fiber organization
E1902958biological_processpositive regulation of mitochondrial electron transport, NADH to ubiquinone
E1903073biological_processnegative regulation of death-inducing signaling complex assembly
E1903094biological_processnegative regulation of protein K48-linked deubiquitination
E1903122biological_processnegative regulation of TRAIL-activated apoptotic signaling pathway
E1903135molecular_functioncupric ion binding
E1903136molecular_functioncuprous ion binding
E1903181biological_processpositive regulation of dopamine biosynthetic process
E1903189biological_processglyoxal metabolic process
E1903190biological_processglyoxal catabolic process
E1903197biological_processpositive regulation of L-dopa biosynthetic process
E1903376biological_processregulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
E1903377biological_processnegative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
E1903384biological_processnegative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway
E1903427biological_processnegative regulation of reactive oxygen species biosynthetic process
E1903428biological_processpositive regulation of reactive oxygen species biosynthetic process
E1903599biological_processpositive regulation of autophagy of mitochondrion
E1903751biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide
E1905259biological_processnegative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway
E1990381molecular_functionubiquitin-specific protease binding
E1990422molecular_functionglyoxalase (glycolic acid-forming) activity
E2000277biological_processpositive regulation of oxidative phosphorylation uncoupler activity
E2000379biological_processpositive regulation of reactive oxygen species metabolic process
E2001237biological_processnegative regulation of extrinsic apoptotic signaling pathway
F0000785cellular_componentchromatin
F0001046molecular_functioncore promoter sequence-specific DNA binding
F0001933biological_processnegative regulation of protein phosphorylation
F0001963biological_processsynaptic transmission, dopaminergic
F0002866biological_processpositive regulation of acute inflammatory response to antigenic stimulus
F0003690molecular_functiondouble-stranded DNA binding
F0003697molecular_functionsingle-stranded DNA binding
F0003713molecular_functiontranscription coactivator activity
F0003723molecular_functionRNA binding
F0003729molecular_functionmRNA binding
F0005102molecular_functionsignaling receptor binding
F0005507molecular_functioncopper ion binding
F0005515molecular_functionprotein binding
F0005634cellular_componentnucleus
F0005654cellular_componentnucleoplasm
F0005737cellular_componentcytoplasm
F0005739cellular_componentmitochondrion
F0005758cellular_componentmitochondrial intermembrane space
F0005759cellular_componentmitochondrial matrix
F0005783cellular_componentendoplasmic reticulum
F0005829cellular_componentcytosol
F0005886cellular_componentplasma membrane
F0005912cellular_componentadherens junction
F0006281biological_processDNA repair
F0006508biological_processproteolysis
F0006914biological_processautophagy
F0006954biological_processinflammatory response
F0006979biological_processresponse to oxidative stress
F0007005biological_processmitochondrion organization
F0007265biological_processRas protein signal transduction
F0007338biological_processsingle fertilization
F0008021cellular_componentsynaptic vesicle
F0008047molecular_functionenzyme activator activity
F0008233molecular_functionpeptidase activity
F0008344biological_processadult locomotory behavior
F0009438biological_processmethylglyoxal metabolic process
F0010273biological_processdetoxification of copper ion
F0010628biological_processpositive regulation of gene expression
F0010629biological_processnegative regulation of gene expression
F0016532molecular_functionsuperoxide dismutase copper chaperone activity
F0016605cellular_componentPML body
F0016684molecular_functionoxidoreductase activity, acting on peroxide as acceptor
F0019249biological_processlactate biosynthetic process
F0019430biological_processremoval of superoxide radicals
F0019826molecular_functionoxygen sensor activity
F0019899molecular_functionenzyme binding
F0019900molecular_functionkinase binding
F0019955molecular_functioncytokine binding
F0030073biological_processinsulin secretion
F0030091biological_processprotein repair
F0030414molecular_functionpeptidase inhibitor activity
F0030424cellular_componentaxon
F0030521biological_processandrogen receptor signaling pathway
F0030546molecular_functionsignaling receptor activator activity
F0031334biological_processpositive regulation of protein-containing complex assembly
F0031397biological_processnegative regulation of protein ubiquitination
F0032435biological_processnegative regulation of proteasomal ubiquitin-dependent protein catabolic process
F0032679biological_processregulation of TRAIL production
F0032757biological_processpositive regulation of interleukin-8 production
F0033138biological_processpositive regulation of peptidyl-serine phosphorylation
F0033234biological_processnegative regulation of protein sumoylation
F0033864biological_processpositive regulation of NAD(P)H oxidase activity
F0034599biological_processcellular response to oxidative stress
F0034614biological_processcellular response to reactive oxygen species
F0036470molecular_functiontyrosine 3-monooxygenase activator activity
F0036471biological_processcellular response to glyoxal
F0036478molecular_functionL-dopa decarboxylase activator activity
F0036524molecular_functionprotein deglycase activity
F0042177biological_processnegative regulation of protein catabolic process
F0042542biological_processresponse to hydrogen peroxide
F0042593biological_processglucose homeostasis
F0042743biological_processhydrogen peroxide metabolic process
F0042802molecular_functionidentical protein binding
F0042803molecular_functionprotein homodimerization activity
F0043005cellular_componentneuron projection
F0043523biological_processregulation of neuron apoptotic process
F0043524biological_processnegative regulation of neuron apoptotic process
F0044297cellular_componentcell body
F0044388molecular_functionsmall protein activating enzyme binding
F0044390molecular_functionubiquitin-like protein conjugating enzyme binding
F0045121cellular_componentmembrane raft
F0045296molecular_functioncadherin binding
F0045340molecular_functionmercury ion binding
F0045944biological_processpositive regulation of transcription by RNA polymerase II
F0046295biological_processglycolate biosynthetic process
F0046826biological_processnegative regulation of protein export from nucleus
F0048471cellular_componentperinuclear region of cytoplasm
F0050681molecular_functionnuclear androgen receptor binding
F0050727biological_processregulation of inflammatory response
F0050787biological_processdetoxification of mercury ion
F0050821biological_processprotein stabilization
F0051583biological_processdopamine uptake involved in synaptic transmission
F0051881biological_processregulation of mitochondrial membrane potential
F0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
F0051899biological_processmembrane depolarization
F0051920molecular_functionperoxiredoxin activity
F0055105molecular_functionubiquitin-protein transferase inhibitor activity
F0060081biological_processmembrane hyperpolarization
F0060765biological_processregulation of androgen receptor signaling pathway
F0061691biological_processdetoxification of hydrogen peroxide
F0061727biological_processmethylglyoxal catabolic process to lactate
F0070062cellular_componentextracellular exosome
F0070301biological_processcellular response to hydrogen peroxide
F0070994biological_processdetection of oxidative stress
F0097110molecular_functionscaffold protein binding
F0106044biological_processguanine deglycation
F0106045biological_processguanine deglycation, methylglyoxal removal
F0106046biological_processguanine deglycation, glyoxal removal
F0110095biological_processcellular detoxification of aldehyde
F0140041biological_processcellular detoxification of methylglyoxal
F0140297molecular_functionDNA-binding transcription factor binding
F1900182biological_processpositive regulation of protein localization to nucleus
F1900242biological_processregulation of synaptic vesicle endocytosis
F1901984biological_processnegative regulation of protein acetylation
F1902176biological_processnegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
F1902177biological_processpositive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
F1902236biological_processnegative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
F1902903biological_processregulation of supramolecular fiber organization
F1902958biological_processpositive regulation of mitochondrial electron transport, NADH to ubiquinone
F1903073biological_processnegative regulation of death-inducing signaling complex assembly
F1903094biological_processnegative regulation of protein K48-linked deubiquitination
F1903122biological_processnegative regulation of TRAIL-activated apoptotic signaling pathway
F1903135molecular_functioncupric ion binding
F1903136molecular_functioncuprous ion binding
F1903181biological_processpositive regulation of dopamine biosynthetic process
F1903189biological_processglyoxal metabolic process
F1903190biological_processglyoxal catabolic process
F1903197biological_processpositive regulation of L-dopa biosynthetic process
F1903376biological_processregulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
F1903377biological_processnegative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
F1903384biological_processnegative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway
F1903427biological_processnegative regulation of reactive oxygen species biosynthetic process
F1903428biological_processpositive regulation of reactive oxygen species biosynthetic process
F1903599biological_processpositive regulation of autophagy of mitochondrion
F1903751biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide
F1905259biological_processnegative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway
F1990381molecular_functionubiquitin-specific protease binding
F1990422molecular_functionglyoxalase (glycolic acid-forming) activity
F2000277biological_processpositive regulation of oxidative phosphorylation uncoupler activity
F2000379biological_processpositive regulation of reactive oxygen species metabolic process
F2001237biological_processnegative regulation of extrinsic apoptotic signaling pathway
G0000785cellular_componentchromatin
G0001046molecular_functioncore promoter sequence-specific DNA binding
G0001933biological_processnegative regulation of protein phosphorylation
G0001963biological_processsynaptic transmission, dopaminergic
G0002866biological_processpositive regulation of acute inflammatory response to antigenic stimulus
G0003690molecular_functiondouble-stranded DNA binding
G0003697molecular_functionsingle-stranded DNA binding
G0003713molecular_functiontranscription coactivator activity
G0003723molecular_functionRNA binding
G0003729molecular_functionmRNA binding
G0005102molecular_functionsignaling receptor binding
G0005507molecular_functioncopper ion binding
G0005515molecular_functionprotein binding
G0005634cellular_componentnucleus
G0005654cellular_componentnucleoplasm
G0005737cellular_componentcytoplasm
G0005739cellular_componentmitochondrion
G0005758cellular_componentmitochondrial intermembrane space
G0005759cellular_componentmitochondrial matrix
G0005783cellular_componentendoplasmic reticulum
G0005829cellular_componentcytosol
G0005886cellular_componentplasma membrane
G0005912cellular_componentadherens junction
G0006281biological_processDNA repair
G0006508biological_processproteolysis
G0006914biological_processautophagy
G0006954biological_processinflammatory response
G0006979biological_processresponse to oxidative stress
G0007005biological_processmitochondrion organization
G0007265biological_processRas protein signal transduction
G0007338biological_processsingle fertilization
G0008021cellular_componentsynaptic vesicle
G0008047molecular_functionenzyme activator activity
G0008233molecular_functionpeptidase activity
G0008344biological_processadult locomotory behavior
G0009438biological_processmethylglyoxal metabolic process
G0010273biological_processdetoxification of copper ion
G0010628biological_processpositive regulation of gene expression
G0010629biological_processnegative regulation of gene expression
G0016532molecular_functionsuperoxide dismutase copper chaperone activity
G0016605cellular_componentPML body
G0016684molecular_functionoxidoreductase activity, acting on peroxide as acceptor
G0019249biological_processlactate biosynthetic process
G0019430biological_processremoval of superoxide radicals
G0019826molecular_functionoxygen sensor activity
G0019899molecular_functionenzyme binding
G0019900molecular_functionkinase binding
G0019955molecular_functioncytokine binding
G0030073biological_processinsulin secretion
G0030091biological_processprotein repair
G0030414molecular_functionpeptidase inhibitor activity
G0030424cellular_componentaxon
G0030521biological_processandrogen receptor signaling pathway
G0030546molecular_functionsignaling receptor activator activity
G0031334biological_processpositive regulation of protein-containing complex assembly
G0031397biological_processnegative regulation of protein ubiquitination
G0032435biological_processnegative regulation of proteasomal ubiquitin-dependent protein catabolic process
G0032679biological_processregulation of TRAIL production
G0032757biological_processpositive regulation of interleukin-8 production
G0033138biological_processpositive regulation of peptidyl-serine phosphorylation
G0033234biological_processnegative regulation of protein sumoylation
G0033864biological_processpositive regulation of NAD(P)H oxidase activity
G0034599biological_processcellular response to oxidative stress
G0034614biological_processcellular response to reactive oxygen species
G0036470molecular_functiontyrosine 3-monooxygenase activator activity
G0036471biological_processcellular response to glyoxal
G0036478molecular_functionL-dopa decarboxylase activator activity
G0036524molecular_functionprotein deglycase activity
G0042177biological_processnegative regulation of protein catabolic process
G0042542biological_processresponse to hydrogen peroxide
G0042593biological_processglucose homeostasis
G0042743biological_processhydrogen peroxide metabolic process
G0042802molecular_functionidentical protein binding
G0042803molecular_functionprotein homodimerization activity
G0043005cellular_componentneuron projection
G0043523biological_processregulation of neuron apoptotic process
G0043524biological_processnegative regulation of neuron apoptotic process
G0044297cellular_componentcell body
G0044388molecular_functionsmall protein activating enzyme binding
G0044390molecular_functionubiquitin-like protein conjugating enzyme binding
G0045121cellular_componentmembrane raft
G0045296molecular_functioncadherin binding
G0045340molecular_functionmercury ion binding
G0045944biological_processpositive regulation of transcription by RNA polymerase II
G0046295biological_processglycolate biosynthetic process
G0046826biological_processnegative regulation of protein export from nucleus
G0048471cellular_componentperinuclear region of cytoplasm
G0050681molecular_functionnuclear androgen receptor binding
G0050727biological_processregulation of inflammatory response
G0050787biological_processdetoxification of mercury ion
G0050821biological_processprotein stabilization
G0051583biological_processdopamine uptake involved in synaptic transmission
G0051881biological_processregulation of mitochondrial membrane potential
G0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
G0051899biological_processmembrane depolarization
G0051920molecular_functionperoxiredoxin activity
G0055105molecular_functionubiquitin-protein transferase inhibitor activity
G0060081biological_processmembrane hyperpolarization
G0060765biological_processregulation of androgen receptor signaling pathway
G0061691biological_processdetoxification of hydrogen peroxide
G0061727biological_processmethylglyoxal catabolic process to lactate
G0070062cellular_componentextracellular exosome
G0070301biological_processcellular response to hydrogen peroxide
G0070994biological_processdetection of oxidative stress
G0097110molecular_functionscaffold protein binding
G0106044biological_processguanine deglycation
G0106045biological_processguanine deglycation, methylglyoxal removal
G0106046biological_processguanine deglycation, glyoxal removal
G0110095biological_processcellular detoxification of aldehyde
G0140041biological_processcellular detoxification of methylglyoxal
G0140297molecular_functionDNA-binding transcription factor binding
G1900182biological_processpositive regulation of protein localization to nucleus
G1900242biological_processregulation of synaptic vesicle endocytosis
G1901984biological_processnegative regulation of protein acetylation
G1902176biological_processnegative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
G1902177biological_processpositive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
G1902236biological_processnegative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway
G1902903biological_processregulation of supramolecular fiber organization
G1902958biological_processpositive regulation of mitochondrial electron transport, NADH to ubiquinone
G1903073biological_processnegative regulation of death-inducing signaling complex assembly
G1903094biological_processnegative regulation of protein K48-linked deubiquitination
G1903122biological_processnegative regulation of TRAIL-activated apoptotic signaling pathway
G1903135molecular_functioncupric ion binding
G1903136molecular_functioncuprous ion binding
G1903181biological_processpositive regulation of dopamine biosynthetic process
G1903189biological_processglyoxal metabolic process
G1903190biological_processglyoxal catabolic process
G1903197biological_processpositive regulation of L-dopa biosynthetic process
G1903376biological_processregulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
G1903377biological_processnegative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway
G1903384biological_processnegative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway
G1903427biological_processnegative regulation of reactive oxygen species biosynthetic process
G1903428biological_processpositive regulation of reactive oxygen species biosynthetic process
G1903599biological_processpositive regulation of autophagy of mitochondrion
G1903751biological_processnegative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide
G1905259biological_processnegative regulation of nitrosative stress-induced intrinsic apoptotic signaling pathway
G1990381molecular_functionubiquitin-specific protease binding
G1990422molecular_functionglyoxalase (glycolic acid-forming) activity
G2000277biological_processpositive regulation of oxidative phosphorylation uncoupler activity
G2000379biological_processpositive regulation of reactive oxygen species metabolic process
G2001237biological_processnegative regulation of extrinsic apoptotic signaling pathway
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE PO4 A 190
ChainResidue
AARG48
AASN76
CHOH95
CGLN580

site_idAC2
Number of Residues6
DetailsBINDING SITE FOR RESIDUE PO4 A 191
ChainResidue
BASN276
AGLN180
AHOH228
BSER247
BARG248
BGLY275

site_idAC3
Number of Residues4
DetailsBINDING SITE FOR RESIDUE PO4 C 3
ChainResidue
CARG448
CASN476
DARG628
EGLN980

site_idAC4
Number of Residues5
DetailsBINDING SITE FOR RESIDUE PO4 D 1
ChainResidue
BGLN380
CARG428
DARG648
DGLY675
DASN676

site_idAC5
Number of Residues4
DetailsBINDING SITE FOR RESIDUE PO4 E 6
ChainResidue
EARG848
EASN876
GHOH174
GGLN1380

site_idAC6
Number of Residues4
DetailsBINDING SITE FOR RESIDUE PO4 F 4
ChainResidue
DHOH126
DGLN780
FARG1048
FASN1076

site_idAC7
Number of Residues6
DetailsBINDING SITE FOR RESIDUE PO4 F 5
ChainResidue
FGLN1180
GGLU1215
GARG1248
GGLY1275
GASN1276
GLEU1277

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues7
DetailsACT_SITE: Nucleophile => ECO:0000305|PubMed:20304780, ECO:0000305|PubMed:25416785
ChainResidueDetails
ACYS106
BCYS306
CCYS506
DCYS706
ECYS906
FCYS1106
GCYS1306

site_idSWS_FT_FI2
Number of Residues7
DetailsACT_SITE: ACT_SITE => ECO:0000305|PubMed:20304780
ChainResidueDetails
AHIS126
BHIS326
CHIS526
DHIS726
EHIS926
FHIS1126
GHIS1326

site_idSWS_FT_FI3
Number of Residues7
DetailsSITE: Cleavage; by CASP6 => ECO:0000250|UniProtKB:Q99LX0
ChainResidueDetails
AASP149
BASP349
CASP549
DASP749
EASP949
FASP1149
GASP1349

site_idSWS_FT_FI4
Number of Residues7
DetailsMOD_RES: N-acetylalanine => ECO:0007744|PubMed:25944712
ChainResidueDetails
AALA2
BALA202
CALA402
DALA602
EALA802
FALA1002
GALA1202

site_idSWS_FT_FI5
Number of Residues7
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:15592455
ChainResidueDetails
ATYR67
BTYR267
CTYR467
DTYR667
ETYR867
FTYR1067
GTYR1267

site_idSWS_FT_FI6
Number of Residues7
DetailsMOD_RES: Cysteine sulfinic acid (-SO2H); alternate => ECO:0000269|PubMed:12939276
ChainResidueDetails
ACYS106
BCYS306
CCYS506
DCYS706
ECYS906
FCYS1106
GCYS1306

site_idSWS_FT_FI7
Number of Residues7
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q99LX0
ChainResidueDetails
ALYS148
BLYS348
CLYS548
DLYS748
ELYS948
FLYS1148
GLYS1348

site_idSWS_FT_FI8
Number of Residues7
DetailsMOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q99LX0
ChainResidueDetails
ALYS182
BLYS382
CLYS582
DLYS782
ELYS982
FLYS1182
GLYS1382

site_idSWS_FT_FI9
Number of Residues14
DetailsLIPID: S-palmitoyl cysteine => ECO:0000269|PubMed:23847046
ChainResidueDetails
ACYS46
ECYS853
FCYS1046
FCYS1053
GCYS1246
GCYS1253
ACYS53
BCYS246
BCYS253
CCYS446
CCYS453
DCYS646
DCYS653
ECYS846

site_idSWS_FT_FI10
Number of Residues7
DetailsLIPID: S-palmitoyl cysteine; alternate => ECO:0000269|PubMed:23847046
ChainResidueDetails
ACYS106
BCYS306
CCYS506
DCYS706
ECYS906
FCYS1106
GCYS1306

site_idSWS_FT_FI11
Number of Residues14
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO) => ECO:0000269|PubMed:15976810
ChainResidueDetails
ALYS130
FLYS1130
GLYS1330
BLYS330
CLYS530
DLYS730
ELYS930

223790

PDB entries from 2024-08-14

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