3BSZ

Crystal structure of the transthyretin-retinol binding protein-Fab complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001523	biological_process	retinoid metabolic process
A	0003105	biological_process	negative regulation of glomerular filtration
A	0005179	molecular_function	hormone activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005737	cellular_component	cytoplasm
A	0006144	biological_process	purine nucleobase metabolic process
A	0007603	biological_process	phototransduction, visible light
A	0032991	cellular_component	protein-containing complex
A	0035578	cellular_component	azurophil granule lumen
A	0042562	molecular_function	hormone binding
A	0042802	molecular_function	identical protein binding
A	0044877	molecular_function	protein-containing complex binding
A	0070062	cellular_component	extracellular exosome
A	0140313	molecular_function	molecular sequestering activity
B	0001523	biological_process	retinoid metabolic process
B	0003105	biological_process	negative regulation of glomerular filtration
B	0005179	molecular_function	hormone activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005737	cellular_component	cytoplasm
B	0006144	biological_process	purine nucleobase metabolic process
B	0007603	biological_process	phototransduction, visible light
B	0032991	cellular_component	protein-containing complex
B	0035578	cellular_component	azurophil granule lumen
B	0042562	molecular_function	hormone binding
B	0042802	molecular_function	identical protein binding
B	0044877	molecular_function	protein-containing complex binding
B	0070062	cellular_component	extracellular exosome
B	0140313	molecular_function	molecular sequestering activity
C	0001523	biological_process	retinoid metabolic process
C	0003105	biological_process	negative regulation of glomerular filtration
C	0005179	molecular_function	hormone activity
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005737	cellular_component	cytoplasm
C	0006144	biological_process	purine nucleobase metabolic process
C	0007603	biological_process	phototransduction, visible light
C	0032991	cellular_component	protein-containing complex
C	0035578	cellular_component	azurophil granule lumen
C	0042562	molecular_function	hormone binding
C	0042802	molecular_function	identical protein binding
C	0044877	molecular_function	protein-containing complex binding
C	0070062	cellular_component	extracellular exosome
C	0140313	molecular_function	molecular sequestering activity
D	0001523	biological_process	retinoid metabolic process
D	0003105	biological_process	negative regulation of glomerular filtration
D	0005179	molecular_function	hormone activity
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005737	cellular_component	cytoplasm
D	0006144	biological_process	purine nucleobase metabolic process
D	0007603	biological_process	phototransduction, visible light
D	0032991	cellular_component	protein-containing complex
D	0035578	cellular_component	azurophil granule lumen
D	0042562	molecular_function	hormone binding
D	0042802	molecular_function	identical protein binding
D	0044877	molecular_function	protein-containing complex binding
D	0070062	cellular_component	extracellular exosome
D	0140313	molecular_function	molecular sequestering activity
E	0001523	biological_process	retinoid metabolic process
E	0001654	biological_process	eye development
E	0002639	biological_process	positive regulation of immunoglobulin production
E	0005501	molecular_function	retinoid binding
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0006094	biological_process	gluconeogenesis
E	0007283	biological_process	spermatogenesis
E	0007507	biological_process	heart development
E	0007601	biological_process	visual perception
E	0007603	biological_process	phototransduction, visible light
E	0008584	biological_process	male gonad development
E	0009410	biological_process	response to xenobiotic stimulus
E	0014850	biological_process	response to muscle activity
E	0016918	molecular_function	retinal binding
E	0019841	molecular_function	retinol binding
E	0030277	biological_process	maintenance of gastrointestinal epithelium
E	0030324	biological_process	lung development
E	0032024	biological_process	positive regulation of insulin secretion
E	0032526	biological_process	response to retinoic acid
E	0032868	biological_process	response to insulin
E	0032991	cellular_component	protein-containing complex
E	0034632	molecular_function	retinol transmembrane transporter activity
E	0034633	biological_process	retinol transport
E	0042572	biological_process	retinol metabolic process
E	0042574	biological_process	retinal metabolic process
E	0042593	biological_process	glucose homeostasis
E	0044877	molecular_function	protein-containing complex binding
E	0045471	biological_process	response to ethanol
E	0048562	biological_process	embryonic organ morphogenesis
E	0048706	biological_process	embryonic skeletal system development
E	0048738	biological_process	cardiac muscle tissue development
E	0048807	biological_process	female genitalia morphogenesis
E	0050908	biological_process	detection of light stimulus involved in visual perception
E	0060041	biological_process	retina development in camera-type eye
E	0060044	biological_process	negative regulation of cardiac muscle cell proliferation
E	0060059	biological_process	embryonic retina morphogenesis in camera-type eye
E	0060065	biological_process	uterus development
E	0060068	biological_process	vagina development
E	0060157	biological_process	urinary bladder development
E	0060347	biological_process	heart trabecula formation
E	0070062	cellular_component	extracellular exosome
E	0071939	biological_process	vitamin A import into cell
E	0140104	molecular_function	molecular carrier activity
F	0001523	biological_process	retinoid metabolic process
F	0001654	biological_process	eye development
F	0002639	biological_process	positive regulation of immunoglobulin production
F	0005501	molecular_function	retinoid binding
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005615	cellular_component	extracellular space
F	0006094	biological_process	gluconeogenesis
F	0007283	biological_process	spermatogenesis
F	0007507	biological_process	heart development
F	0007601	biological_process	visual perception
F	0007603	biological_process	phototransduction, visible light
F	0008584	biological_process	male gonad development
F	0009410	biological_process	response to xenobiotic stimulus
F	0014850	biological_process	response to muscle activity
F	0016918	molecular_function	retinal binding
F	0019841	molecular_function	retinol binding
F	0030277	biological_process	maintenance of gastrointestinal epithelium
F	0030324	biological_process	lung development
F	0032024	biological_process	positive regulation of insulin secretion
F	0032526	biological_process	response to retinoic acid
F	0032868	biological_process	response to insulin
F	0032991	cellular_component	protein-containing complex
F	0034632	molecular_function	retinol transmembrane transporter activity
F	0034633	biological_process	retinol transport
F	0042572	biological_process	retinol metabolic process
F	0042574	biological_process	retinal metabolic process
F	0042593	biological_process	glucose homeostasis
F	0044877	molecular_function	protein-containing complex binding
F	0045471	biological_process	response to ethanol
F	0048562	biological_process	embryonic organ morphogenesis
F	0048706	biological_process	embryonic skeletal system development
F	0048738	biological_process	cardiac muscle tissue development
F	0048807	biological_process	female genitalia morphogenesis
F	0050908	biological_process	detection of light stimulus involved in visual perception
F	0060041	biological_process	retina development in camera-type eye
F	0060044	biological_process	negative regulation of cardiac muscle cell proliferation
F	0060059	biological_process	embryonic retina morphogenesis in camera-type eye
F	0060065	biological_process	uterus development
F	0060068	biological_process	vagina development
F	0060157	biological_process	urinary bladder development
F	0060347	biological_process	heart trabecula formation
F	0070062	cellular_component	extracellular exosome
F	0071939	biological_process	vitamin A import into cell
F	0140104	molecular_function	molecular carrier activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	9
Details	BINDING SITE FOR RESIDUE RTL E 177

Chain	Residue
B	GLY83
E	PHE36
E	LEU37
E	MET73
E	MET88
E	LEU97
E	GLN98
E	HIS104
E	PHE135

---

site_id	AC2
Number of Residues	8
Details	BINDING SITE FOR RESIDUE RTL F 178

Chain	Residue
D	GLY83
F	PHE36
F	LEU37
F	MET73
F	MET88
F	GLN98
F	HIS104
F	PHE135

---

Functional Information from PROSITE/UniProt

site_id	PS00213
Number of Residues	14
Details	LIPOCALIN Lipocalin signature. NFDkaRFSGTWYAM

Chain	Residue	Details
E	ASN14-MET27

---

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH

Chain	Residue	Details
L	TYR196-HIS202

---

site_id	PS00768
Number of Residues	16
Details	TRANSTHYRETIN_1 Transthyretin signature 1. KVLDavrGsPAinVaV

Chain	Residue	Details
A	LYS15-VAL30

---

site_id	PS00769
Number of Residues	13
Details	TRANSTHYRETIN_2 Transthyretin signature 2. YTIAalLSPYSYS

Chain	Residue	Details
A	TYR105-SER117

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11418763","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1ICT","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Modified residue: {"description":"Sulfocysteine","evidences":[{"source":"PubMed","id":"17175208","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2H4E","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Modified residue: {"description":"4-carboxyglutamate; in a patient with Moyamoya disease","evidences":[{"source":"PubMed","id":"18221012","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P02767","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19167329","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P27485","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Modified residue: {"description":"Omega-N-methylarginine","evidences":[{"source":"UniProtKB","id":"Q00724","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---