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3BRW

Structure of the Rap-RapGAP complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0005096molecular_functionGTPase activator activity
A0051056biological_processregulation of small GTPase mediated signal transduction
B0005096molecular_functionGTPase activator activity
B0051056biological_processregulation of small GTPase mediated signal transduction
C0005096molecular_functionGTPase activator activity
C0051056biological_processregulation of small GTPase mediated signal transduction
D0003924molecular_functionGTPase activity
D0003925molecular_functionG protein activity
D0005515molecular_functionprotein binding
D0005525molecular_functionGTP binding
D0005737cellular_componentcytoplasm
D0005811cellular_componentlipid droplet
D0005829cellular_componentcytosol
D0005886cellular_componentplasma membrane
D0005911cellular_componentcell-cell junction
D0007165biological_processsignal transduction
D0007264biological_processsmall GTPase-mediated signal transduction
D0008283biological_processcell population proliferation
D0016020cellular_componentmembrane
D0016787molecular_functionhydrolase activity
D0017156biological_processcalcium-ion regulated exocytosis
D0019003molecular_functionGDP binding
D0030033biological_processmicrovillus assembly
D0032486biological_processRap protein signal transduction
D0033625biological_processpositive regulation of integrin activation
D0035577cellular_componentazurophil granule membrane
D0044877molecular_functionprotein-containing complex binding
D0045121cellular_componentmembrane raft
D0045955biological_processnegative regulation of calcium ion-dependent exocytosis
D0051649biological_processestablishment of localization in cell
D0061028biological_processestablishment of endothelial barrier
D0070062cellular_componentextracellular exosome
D0070161cellular_componentanchoring junction
D0070374biological_processpositive regulation of ERK1 and ERK2 cascade
D0071320biological_processcellular response to cAMP
D0098978cellular_componentglutamatergic synapse
D0099010biological_processmodification of postsynaptic structure
D1901888biological_processregulation of cell junction assembly
D2000114biological_processregulation of establishment of cell polarity
D2000301biological_processnegative regulation of synaptic vesicle exocytosis
Functional Information from PDB Data
site_idAC1
Number of Residues4
DetailsBINDING SITE FOR RESIDUE MG D 172
ChainResidue
DSER17
DTHR35
DHOH174
DHOH175

site_idAC2
Number of Residues9
DetailsBINDING SITE FOR RESIDUE BEF D 170
ChainResidue
DPRO34
DTHR35
DGLY60
DHOH175
BASN290
DGLY12
DGLY13
DLYS16
DTYR32

site_idAC3
Number of Residues18
DetailsBINDING SITE FOR RESIDUE GDP D 171
ChainResidue
BGLN280
DGLY13
DGLY15
DLYS16
DSER17
DALA18
DGLU30
DLYS31
DTYR32
DASN116
DLYS117
DASP119
DLEU120
DSER147
DALA148
DLYS149
DHOH174
DHOH175

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsBINDING: BINDING => ECO:0000269|PubMed:18309292, ECO:0000269|PubMed:22577140
ChainResidueDetails
DGLY10
DASP57
DASN116
DSER147

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: ADP-ribosylserine; by botulinum toxin => ECO:0000305|PubMed:3141412
ChainResidueDetails
DSER39

Catalytic Information from CSA
site_idCSA1
Number of Residues1
DetailsAnnotated By Reference To The Literature 1ksj
ChainResidueDetails
DTHR61

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PDB entries from 2024-11-06

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