3BRW
Structure of the Rap-RapGAP complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005096 | molecular_function | GTPase activator activity |
| A | 0051056 | biological_process | regulation of small GTPase mediated signal transduction |
| B | 0005096 | molecular_function | GTPase activator activity |
| B | 0051056 | biological_process | regulation of small GTPase mediated signal transduction |
| C | 0005096 | molecular_function | GTPase activator activity |
| C | 0051056 | biological_process | regulation of small GTPase mediated signal transduction |
| D | 0000166 | molecular_function | nucleotide binding |
| D | 0003924 | molecular_function | GTPase activity |
| D | 0003925 | molecular_function | G protein activity |
| D | 0005515 | molecular_function | protein binding |
| D | 0005525 | molecular_function | GTP binding |
| D | 0005811 | cellular_component | lipid droplet |
| D | 0005829 | cellular_component | cytosol |
| D | 0005886 | cellular_component | plasma membrane |
| D | 0005911 | cellular_component | cell-cell junction |
| D | 0007165 | biological_process | signal transduction |
| D | 0007189 | biological_process | adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| D | 0016020 | cellular_component | membrane |
| D | 0016787 | molecular_function | hydrolase activity |
| D | 0019003 | molecular_function | GDP binding |
| D | 0030073 | biological_process | insulin secretion |
| D | 0031045 | cellular_component | dense core granule |
| D | 0032486 | biological_process | Rap protein signal transduction |
| D | 0033625 | biological_process | positive regulation of integrin activation |
| D | 0035577 | cellular_component | azurophil granule membrane |
| D | 0044877 | molecular_function | protein-containing complex binding |
| D | 0045121 | cellular_component | membrane raft |
| D | 0061028 | biological_process | establishment of endothelial barrier |
| D | 0070062 | cellular_component | extracellular exosome |
| D | 0070161 | cellular_component | anchoring junction |
| D | 0071320 | biological_process | cellular response to cAMP |
| D | 0098978 | cellular_component | glutamatergic synapse |
| D | 0099010 | biological_process | modification of postsynaptic structure |
| D | 1901888 | biological_process | regulation of cell junction assembly |
| D | 2000114 | biological_process | regulation of establishment of cell polarity |
| D | 2000301 | biological_process | negative regulation of synaptic vesicle exocytosis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MG D 172 |
| Chain | Residue |
| D | SER17 |
| D | THR35 |
| D | HOH174 |
| D | HOH175 |
| site_id | AC2 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE BEF D 170 |
| Chain | Residue |
| D | PRO34 |
| D | THR35 |
| D | GLY60 |
| D | HOH175 |
| B | ASN290 |
| D | GLY12 |
| D | GLY13 |
| D | LYS16 |
| D | TYR32 |
| site_id | AC3 |
| Number of Residues | 18 |
| Details | BINDING SITE FOR RESIDUE GDP D 171 |
| Chain | Residue |
| B | GLN280 |
| D | GLY13 |
| D | GLY15 |
| D | LYS16 |
| D | SER17 |
| D | ALA18 |
| D | GLU30 |
| D | LYS31 |
| D | TYR32 |
| D | ASN116 |
| D | LYS117 |
| D | ASP119 |
| D | LEU120 |
| D | SER147 |
| D | ALA148 |
| D | LYS149 |
| D | HOH174 |
| D | HOH175 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 432 |
| Details | Domain: {"description":"Rap-GAP","evidences":[{"source":"PROSITE-ProRule","id":"PRU00165","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 42 |
| Details | Region: {"description":"Interaction with KRIT1","evidences":[{"source":"PubMed","id":"22577140","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Motif: {"description":"Effector region","evidences":[{"evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 17 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"18309292","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"22577140","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"ADP-ribosylserine; by botulinum toxin","evidences":[{"source":"PubMed","id":"3141412","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1ksj |
| Chain | Residue | Details |
| D | THR61 |
