3BPT
Crystal structure of human beta-hydroxyisobutyryl-CoA hydrolase in complex with quercetin
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003860 | molecular_function | 3-hydroxyisobutyryl-CoA hydrolase activity |
A | 0005739 | cellular_component | mitochondrion |
A | 0005759 | cellular_component | mitochondrial matrix |
A | 0006574 | biological_process | valine catabolic process |
A | 0009083 | biological_process | branched-chain amino acid catabolic process |
A | 0016787 | molecular_function | hydrolase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE QUE A 501 |
Chain | Residue |
A | PHE56 |
A | LEU350 |
A | HIU502 |
A | HOH886 |
A | HOH924 |
A | LEU57 |
A | ALA59 |
A | GLY97 |
A | GLY98 |
A | ILE100 |
A | PRO168 |
A | ILE172 |
A | VAL349 |
site_id | AC2 |
Number of Residues | 11 |
Details | BINDING SITE FOR RESIDUE HIU A 502 |
Chain | Residue |
A | GLY97 |
A | GLY98 |
A | ILE100 |
A | PHE118 |
A | GLU121 |
A | GLY146 |
A | GLU169 |
A | LEU174 |
A | ASP177 |
A | VAL178 |
A | QUE501 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 4 |
Details | BINDING: |
Chain | Residue | Details |
A | GLU121 | |
A | GLY146 | |
A | GLU169 | |
A | ASP177 |
site_id | SWS_FT_FI2 |
Number of Residues | 5 |
Details | MOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q8QZS1 |
Chain | Residue | Details |
A | LYS55 | |
A | LYS92 | |
A | LYS221 | |
A | LYS297 | |
A | LYS353 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
A | SER234 | |
A | SER356 |
site_id | SWS_FT_FI4 |
Number of Residues | 3 |
Details | MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q8QZS1 |
Chain | Residue | Details |
A | LYS257 | |
A | LYS301 | |
A | LYS377 |
site_id | SWS_FT_FI5 |
Number of Residues | 2 |
Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q8QZS1 |
Chain | Residue | Details |
A | LYS360 | |
A | LYS365 |
Catalytic Information from CSA
site_id | CSA1 |
Number of Residues | 2 |
Details | Annotated By Reference To The Literature 1dci |
Chain | Residue | Details |
A | ASP177 | |
A | GLU169 |
site_id | CSA2 |
Number of Residues | 3 |
Details | Annotated By Reference To The Literature 1dci |
Chain | Residue | Details |
A | GLU169 | |
A | GLY149 | |
A | GLY146 |
site_id | MCSA1 |
Number of Residues | 4 |
Details | M-CSA 345 |
Chain | Residue | Details |
A | GLY98 | electrostatic stabiliser, hydrogen bond donor |
A | GLY146 | electrostatic stabiliser, hydrogen bond donor |
A | GLU169 | activator, covalently attached, electrofuge, electrophile, hydrogen bond donor, nucleophile, polar interaction, proton donor |
A | ASP177 | hydrogen bond acceptor, hydrogen bond donor, increase acidity, proton acceptor, proton donor |