3BOM

Crystal structure of trout hemoglobin at 1.35 Angstrom resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004601	molecular_function	peroxidase activity
A	0005344	molecular_function	oxygen carrier activity
A	0005833	cellular_component	hemoglobin complex
A	0015671	biological_process	oxygen transport
A	0019825	molecular_function	oxygen binding
A	0020037	molecular_function	heme binding
A	0031720	molecular_function	haptoglobin binding
A	0031838	cellular_component	haptoglobin-hemoglobin complex
A	0042744	biological_process	hydrogen peroxide catabolic process
A	0043177	molecular_function	organic acid binding
A	0046872	molecular_function	metal ion binding
A	0072562	cellular_component	blood microparticle
A	0098869	biological_process	cellular oxidant detoxification
B	0004601	molecular_function	peroxidase activity
B	0005344	molecular_function	oxygen carrier activity
B	0005833	cellular_component	hemoglobin complex
B	0015671	biological_process	oxygen transport
B	0019825	molecular_function	oxygen binding
B	0020037	molecular_function	heme binding
B	0031720	molecular_function	haptoglobin binding
B	0031838	cellular_component	haptoglobin-hemoglobin complex
B	0042744	biological_process	hydrogen peroxide catabolic process
B	0043177	molecular_function	organic acid binding
B	0046872	molecular_function	metal ion binding
B	0072562	cellular_component	blood microparticle
B	0098869	biological_process	cellular oxidant detoxification
C	0004601	molecular_function	peroxidase activity
C	0005344	molecular_function	oxygen carrier activity
C	0005833	cellular_component	hemoglobin complex
C	0015671	biological_process	oxygen transport
C	0019825	molecular_function	oxygen binding
C	0020037	molecular_function	heme binding
C	0031720	molecular_function	haptoglobin binding
C	0031838	cellular_component	haptoglobin-hemoglobin complex
C	0042744	biological_process	hydrogen peroxide catabolic process
C	0043177	molecular_function	organic acid binding
C	0046872	molecular_function	metal ion binding
C	0072562	cellular_component	blood microparticle
C	0098869	biological_process	cellular oxidant detoxification
D	0004601	molecular_function	peroxidase activity
D	0005344	molecular_function	oxygen carrier activity
D	0005833	cellular_component	hemoglobin complex
D	0015671	biological_process	oxygen transport
D	0019825	molecular_function	oxygen binding
D	0020037	molecular_function	heme binding
D	0031720	molecular_function	haptoglobin binding
D	0031838	cellular_component	haptoglobin-hemoglobin complex
D	0042744	biological_process	hydrogen peroxide catabolic process
D	0043177	molecular_function	organic acid binding
D	0046872	molecular_function	metal ion binding
D	0072562	cellular_component	blood microparticle
D	0098869	biological_process	cellular oxidant detoxification

Functional Information from PDB Data

site_id	AC1
Number of Residues	23
Details	BINDING SITE FOR RESIDUE HEM A 143

Chain	Residue
A	TYR42
A	VAL94
A	ASN98
A	PHE99
A	LEU102
A	LEU137
A	HOH225
A	HOH246
A	HOH251
A	HOH263
A	HOH318
A	PHE43
A	HOH319
A	HOH321
A	HOH343
A	HOH345
A	HIS45
A	TRP46
A	HIS59
A	THR62
A	LEU87
A	HIS88
A	LEU92

---

site_id	AC2
Number of Residues	14
Details	BINDING SITE FOR RESIDUE HEM B 148

Chain	Residue
B	HIS41
B	PHE45
B	HIS63
B	VAL67
B	MET91
B	HIS92
B	LEU96
B	ASN102
B	PHE103
B	LEU106
B	LEU142
B	HOH2941
B	HOH2958
D	LYS95

---

site_id	AC3
Number of Residues	21
Details	BINDING SITE FOR RESIDUE HEM C 143

Chain	Residue
C	TYR42
C	PHE43
C	HIS45
C	TRP46
C	HIS59
C	THR62
C	HIS88
C	LEU92
C	VAL94
C	ASN98
C	LEU102
C	LEU137
C	EDO2775
C	HOH2837
C	HOH2889
C	HOH2925
C	HOH2942
C	HOH2949
C	HOH2951
C	HOH2959
C	HOH2980

---

site_id	AC4
Number of Residues	13
Details	BINDING SITE FOR RESIDUE HEM D 148

Chain	Residue
D	HIS63
D	VAL67
D	LEU88
D	MET91
D	HIS92
D	LEU96
D	ASN102
D	PHE103
D	LEU106
D	LEU142
D	HOH2903
D	HOH2934
D	HOH2957

---

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO B 2775

Chain	Residue
A	HOH166
B	ARG104
B	ALA107
B	ASP108
B	GLN132
B	HOH2836
B	HOH2978

---

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO D 2775

Chain	Residue
D	ARG104
D	ALA107
D	ASP108
D	GLN132
D	VAL139
D	HOH2811
D	HOH2918

---

site_id	AC7
Number of Residues	7
Details	BINDING SITE FOR RESIDUE EDO C 2775

Chain	Residue
C	TRP46
C	LYS58
C	HIS59
C	THR62
C	HEM143
C	HOH2830
C	HOH2964

---

site_id	AC8
Number of Residues	6
Details	BINDING SITE FOR RESIDUE EDO C 2776

Chain	Residue
C	GLU26
C	SER30
C	PRO51
C	GLY52
C	HOH2781
C	HOH2953

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00238","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {"description":"proximal binding residue","evidences":[{"source":"PROSITE-ProRule","id":"PRU00238","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"N-acetylserine","evidences":[{"source":"PubMed","id":"2706274","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	290
Details	Domain: {"description":"Globin","evidences":[{"source":"PROSITE-ProRule","id":"PRU00238","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"description":"distal binding residue"}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Binding site: {"description":"proximal binding residue"}

Chain

Residue

Details

---