3BNU
Crystal structure of polyamine oxidase FMS1 from Saccharomyces cerevisiae in complex with bis-(3S,3'S)-methylated spermine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003682 | molecular_function | chromatin binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006338 | biological_process | chromatin remodeling |
| A | 0015940 | biological_process | pantothenate biosynthetic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0046208 | biological_process | spermine catabolic process |
| A | 0046592 | molecular_function | polyamine oxidase activity |
| A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| A | 0052897 | molecular_function | N8-acetylspermidine:oxygen oxidoreductase (propane-1,3-diamine-forming) activity |
| A | 0052901 | molecular_function | spermine:oxygen oxidoreductase (spermidine-forming) activity |
| A | 0052902 | molecular_function | spermidine:oxygen oxidoreductase (3-aminopropanal-forming) activity |
| A | 0052903 | molecular_function | N1-acetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity |
| A | 0052904 | molecular_function | N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity |
| B | 0003682 | molecular_function | chromatin binding |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006338 | biological_process | chromatin remodeling |
| B | 0015940 | biological_process | pantothenate biosynthetic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0046208 | biological_process | spermine catabolic process |
| B | 0046592 | molecular_function | polyamine oxidase activity |
| B | 0050660 | molecular_function | flavin adenine dinucleotide binding |
| B | 0052897 | molecular_function | N8-acetylspermidine:oxygen oxidoreductase (propane-1,3-diamine-forming) activity |
| B | 0052901 | molecular_function | spermine:oxygen oxidoreductase (spermidine-forming) activity |
| B | 0052902 | molecular_function | spermidine:oxygen oxidoreductase (3-aminopropanal-forming) activity |
| B | 0052903 | molecular_function | N1-acetylspermine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity |
| B | 0052904 | molecular_function | N1-acetylspermidine:oxygen oxidoreductase (3-acetamidopropanal-forming) activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 37 |
| Details | BINDING SITE FOR RESIDUE FAD B 802 |
| Chain | Residue |
| B | GLY15 |
| B | GLY62 |
| B | ALA63 |
| B | SER64 |
| B | TRP65 |
| B | HIS67 |
| B | CYS221 |
| B | VAL223 |
| B | THR252 |
| B | VAL253 |
| B | GLY270 |
| B | GLY17 |
| B | LEU294 |
| B | TYR445 |
| B | ALA449 |
| B | TYR450 |
| B | GLY478 |
| B | GLU479 |
| B | GLY487 |
| B | CYS488 |
| B | ALA489 |
| B | ALA492 |
| B | ILE18 |
| B | SPZ803 |
| B | HOH807 |
| B | HOH818 |
| B | HOH829 |
| B | HOH893 |
| B | HOH905 |
| B | HOH909 |
| B | HOH911 |
| B | ALA19 |
| B | GLU39 |
| B | ALA40 |
| B | ARG41 |
| B | GLY46 |
| B | ARG47 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE SPZ B 803 |
| Chain | Residue |
| B | TRP65 |
| B | HIS67 |
| B | LEU173 |
| B | TRP174 |
| B | PHE189 |
| B | LEU294 |
| B | TYR450 |
| B | ALA486 |
| B | CYS488 |
| B | FAD802 |
| site_id | AC3 |
| Number of Residues | 36 |
| Details | BINDING SITE FOR RESIDUE FAD A 801 |
| Chain | Residue |
| A | GLY15 |
| A | GLY17 |
| A | ILE18 |
| A | ALA19 |
| A | GLU39 |
| A | ALA40 |
| A | ARG41 |
| A | GLY46 |
| A | ARG47 |
| A | GLY62 |
| A | ALA63 |
| A | SER64 |
| A | TRP65 |
| A | HIS67 |
| A | VAL223 |
| A | THR252 |
| A | VAL253 |
| A | GLY270 |
| A | LEU294 |
| A | TYR445 |
| A | ALA449 |
| A | TYR450 |
| A | GLY478 |
| A | GLU479 |
| A | GLY487 |
| A | CYS488 |
| A | ALA489 |
| A | ALA492 |
| A | SPZ802 |
| A | HOH803 |
| A | HOH809 |
| A | HOH814 |
| A | HOH820 |
| A | HOH827 |
| A | HOH830 |
| A | HOH839 |
| site_id | AC4 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE SPZ A 802 |
| Chain | Residue |
| A | TRP65 |
| A | HIS67 |
| A | ASP68 |
| A | LEU173 |
| A | TRP174 |
| A | PHE189 |
| A | LEU375 |
| A | TYR450 |
| A | ALA486 |
| A | CYS488 |
| A | FAD801 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1f8r |
| Chain | Residue | Details |
| B | GLY193 | |
| B | LYS296 |
| site_id | CSA2 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1f8r |
| Chain | Residue | Details |
| A | GLY193 | |
| A | LYS296 |
| site_id | CSA3 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1f8r |
| Chain | Residue | Details |
| B | HIS67 |
| site_id | CSA4 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1f8r |
| Chain | Residue | Details |
| A | HIS67 |
