3BI7
Crystal structure of the SRA domain of E3 ubiquitin-protein ligase UHRF1
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 A 5 |
| Chain | Residue |
| A | ARG431 |
| A | PHE432 |
| A | TRP527 |
| A | ARG528 |
| A | ARG581 |
| A | UNL625 |
| A | HOH719 |
| A | HOH817 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 1 |
| Chain | Residue |
| A | ASN474 |
| A | ARG582 |
| A | ASP584 |
| A | HOH644 |
| A | HOH816 |
| A | HIS445 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 2 |
| Chain | Residue |
| A | VAL434 |
| A | ASN474 |
| A | ARG581 |
| A | UNL625 |
| A | HOH653 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE EDO A 3 |
| Chain | Residue |
| A | VAL470 |
| A | ASP471 |
| A | PHE513 |
| A | ASN544 |
| A | HOH628 |
| site_id | AC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE EDO A 4 |
| Chain | Residue |
| A | GLU438 |
| A | ARG443 |
| A | ASP518 |
| A | LYS592 |
| A | HOH662 |
| A | HOH716 |
| site_id | AC6 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE UNL A 625 |
| Chain | Residue |
| A | EDO2 |
| A | SO45 |
| A | PHE432 |
| A | ARG433 |
| A | VAL434 |
| A | ARG528 |
| A | ARG581 |
| A | HOH643 |
| A | HOH653 |
| A | HOH689 |
| A | HOH694 |
| A | HOH815 |
| A | HOH816 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Region: {"description":"Required to promote base flipping","evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 3 |
| Details | Region: {"description":"Required for formation of a 5-methylcytosine-binding pocket"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Site: {"description":"Required to discriminate between hemimethylated DNA versus symmetrically methylated DNA"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Site: {"description":"Required for affinity and specificity for 5-mCpG sequence"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-acetyllysine; alternate","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate","evidences":[{"source":"PubMed","id":"25218447","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
