3BGV
Crystal structure of mRNA cap guanine-N7 methyltransferase in complex with SAH
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004482 | molecular_function | mRNA 5'-cap (guanine-N7-)-methyltransferase activity |
| A | 0006370 | biological_process | 7-methylguanosine mRNA capping |
| B | 0004482 | molecular_function | mRNA 5'-cap (guanine-N7-)-methyltransferase activity |
| B | 0006370 | biological_process | 7-methylguanosine mRNA capping |
| C | 0004482 | molecular_function | mRNA 5'-cap (guanine-N7-)-methyltransferase activity |
| C | 0006370 | biological_process | 7-methylguanosine mRNA capping |
| D | 0004482 | molecular_function | mRNA 5'-cap (guanine-N7-)-methyltransferase activity |
| D | 0006370 | biological_process | 7-methylguanosine mRNA capping |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE SAH C 313 |
| Chain | Residue |
| A | LYS16 |
| A | VAL122 |
| A | TYR125 |
| A | MET136 |
| A | HOH323 |
| C | HOH471 |
| A | GLY41 |
| A | GLY43 |
| A | ASP63 |
| A | ILE64 |
| A | ASP97 |
| A | SER98 |
| A | GLN120 |
| A | PHE121 |
| site_id | AC2 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE SAH C 314 |
| Chain | Residue |
| B | LYS16 |
| B | GLY41 |
| B | CYS42 |
| B | GLY43 |
| B | ASP63 |
| B | ILE64 |
| B | ASP97 |
| B | SER98 |
| B | GLN120 |
| B | PHE121 |
| B | VAL122 |
| B | TYR125 |
| B | HOH325 |
| B | HOH327 |
| B | HOH330 |
| C | HOH494 |
| C | HOH544 |
| site_id | AC3 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE SAH C 315 |
| Chain | Residue |
| C | LYS16 |
| C | GLY41 |
| C | GLY43 |
| C | ASP63 |
| C | ILE64 |
| C | ASP97 |
| C | SER98 |
| C | GLN120 |
| C | PHE121 |
| C | VAL122 |
| C | TYR125 |
| C | MET136 |
| C | HOH434 |
| C | HOH439 |
| C | HOH450 |
| C | HOH477 |
| C | HOH519 |
| site_id | AC4 |
| Number of Residues | 19 |
| Details | BINDING SITE FOR RESIDUE SAH C 316 |
| Chain | Residue |
| C | HOH487 |
| C | HOH506 |
| C | HOH526 |
| D | LYS16 |
| D | GLY41 |
| D | GLY43 |
| D | ASP63 |
| D | ILE64 |
| D | ALA96 |
| D | ASP97 |
| D | SER98 |
| D | GLN120 |
| D | PHE121 |
| D | VAL122 |
| D | TYR125 |
| D | MET136 |
| D | HOH324 |
| D | HOH327 |
| D | HOH341 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00895 |
| Chain | Residue | Details |
| A | ASN12 | |
| B | ASN12 | |
| C | ASN12 | |
| D | ASN12 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00895, ECO:0000269|PubMed:27422871, ECO:0007744|PDB:3BGV, ECO:0007744|PDB:5E9J, ECO:0007744|PDB:5E9W |
| Chain | Residue | Details |
| A | LYS16 | |
| D | LYS16 | |
| D | GLY41 | |
| D | ASP63 | |
| A | GLY41 | |
| A | ASP63 | |
| B | LYS16 | |
| B | GLY41 | |
| B | ASP63 | |
| C | LYS16 | |
| C | GLY41 | |
| C | ASP63 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:27422871, ECO:0007744|PDB:3BGV, ECO:0007744|PDB:5E9J, ECO:0007744|PDB:5E9W |
| Chain | Residue | Details |
| A | ASP97 | |
| D | ASP97 | |
| D | GLN120 | |
| D | TYR125 | |
| A | GLN120 | |
| A | TYR125 | |
| B | ASP97 | |
| B | GLN120 | |
| B | TYR125 | |
| C | ASP97 | |
| C | GLN120 | |
| C | TYR125 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 24 |
| Details | SITE: mRNA cap binding => ECO:0000255|PROSITE-ProRule:PRU00895 |
| Chain | Residue | Details |
| A | LYS44 | |
| B | HIS124 | |
| B | GLU206 | |
| B | TYR303 | |
| C | LYS44 | |
| C | LYS50 | |
| C | ARG75 | |
| C | HIS124 | |
| C | GLU206 | |
| C | TYR303 | |
| D | LYS44 | |
| A | LYS50 | |
| D | LYS50 | |
| D | ARG75 | |
| D | HIS124 | |
| D | GLU206 | |
| D | TYR303 | |
| A | ARG75 | |
| A | HIS124 | |
| A | GLU206 | |
| A | TYR303 | |
| B | LYS44 | |
| B | LYS50 | |
| B | ARG75 |
