Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
| B | 0004252 | molecular_function | serine-type endopeptidase activity |
| B | 0006508 | biological_process | proteolysis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 A 246 |
| Chain | Residue |
| A | HIS57 |
| A | GLN192 |
| A | GLY193 |
| A | SER195 |
| A | HOH433 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA A 248 |
| Chain | Residue |
| A | HOH451 |
| A | TYR185 |
| A | ASP185 |
| A | ARG222 |
| A | LYS224 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA A 249 |
| Chain | Residue |
| A | ASP165 |
| A | ALA177 |
| A | MET180 |
| A | GLU230 |
| A | HOH272 |
| A | HOH279 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE SO4 B 246 |
| Chain | Residue |
| B | HIS57 |
| B | GLN192 |
| B | GLY193 |
| B | SER195 |
| B | HOH344 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE NA B 248 |
| Chain | Residue |
| B | TYR185 |
| B | ASP185 |
| B | ARG222 |
| B | LYS224 |
| B | HOH410 |
| site_id | AC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 249 |
| Chain | Residue |
| B | ASP165 |
| B | ALA177 |
| B | MET180 |
| B | GLU230 |
| B | HOH280 |
| B | HOH286 |
| site_id | AC7 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE SO4 A 1 |
| Chain | Residue |
| A | TYR185 |
| A | ASP185 |
| A | THR185 |
| A | LYS186 |
| A | ARG243 |
| A | HOH278 |
| A | HOH339 |
| A | HOH414 |
| A | HOH440 |
| A | HOH473 |
| A | HOH568 |
| site_id | AC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 B 2 |
| Chain | Residue |
| A | ARG84 |
| B | GLY60 |
| B | SER60 |
| B | HOH269 |
| B | HOH402 |
| B | HOH424 |
| B | HOH470 |
| site_id | AC9 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE SO4 A 3 |
| Chain | Residue |
| A | ARG84 |
| A | ALA158 |
| A | ASN159 |
| A | GLU188 |
| A | HOH285 |
| A | HOH313 |
| A | HOH334 |
| A | HOH337 |
| A | HOH507 |
| site_id | BC1 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE SO4 B 4 |
| Chain | Residue |
| A | SER173 |
| A | GLU217 |
| A | LYS224 |
| A | HOH351 |
| B | TYR185 |
| B | ASP185 |
| B | HOH321 |
| B | HOH404 |
| B | HOH435 |
| B | HOH456 |
| B | HOH524 |
| site_id | BC2 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE SO4 B 5 |
| Chain | Residue |
| B | LYS122 |
| B | HOH313 |
| B | HOH330 |
| B | HOH332 |
| B | HOH335 |
| B | HOH337 |
| B | HOH436 |
| B | HOH519 |
| site_id | BC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE SO4 A 6 |
| Chain | Residue |
| A | SER60 |
| A | ASN61 |
| A | SER63 |
| A | HOH282 |
| A | HOH314 |
| A | HOH513 |
| B | SER60 |
| B | ASN61 |
| B | SER63 |
| B | ILE64 |
| site_id | BC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 9 |
| Chain | Residue |
| A | THR86 |
| A | LYS87 |
| A | LYS107 |
| A | HOH284 |
| A | HOH293 |
| A | HOH449 |
| site_id | BC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE SO4 B 10 |
| Chain | Residue |
| B | HOH302 |
| B | HOH360 |
| A | GLY60 |
| A | SER60 |
| A | GLN90 |
| A | HOH471 |
| B | ARG84 |
| site_id | BC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE SO4 A 11 |
| Chain | Residue |
| A | THR135 |
| A | ARG201 |
| A | LYS202 |
| A | HOH371 |
| A | HOH423 |
| A | HOH515 |
| site_id | BC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE BEN A 247 |
| Chain | Residue |
| A | ASP189 |
| A | THR190 |
| A | GLN192 |
| A | SER195 |
| A | TRP215 |
| A | GLY216 |
| A | GLY219 |
| A | GLY226 |
| site_id | BC8 |
| Number of Residues | 9 |
| Details | BINDING SITE FOR RESIDUE BEN B 247 |
| Chain | Residue |
| B | ASP189 |
| B | THR190 |
| B | CYS191 |
| B | GLN192 |
| B | SER195 |
| B | TRP215 |
| B | GLY216 |
| B | GLY219 |
| B | GLY226 |
| site_id | BC9 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE BEN A 7 |
| Chain | Residue |
| A | MET35 |
| A | GLY41 |
| A | CYS42 |
| A | HIS57 |
| A | CYS58 |
| A | HOH433 |
| A | HOH497 |
| A | HOH513 |
| B | MET35 |
| B | HIS57 |
| B | CYS58 |
| site_id | CC1 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE BEN A 8 |
| Chain | Residue |
| A | GLY60 |
| A | ASN60 |
| A | GLN133 |
| A | THR244 |
| A | LEU245 |
| A | HOH350 |
| A | HOH408 |
| A | HOH511 |
Functional Information from PROSITE/UniProt
| site_id | PS00134 |
| Number of Residues | 6 |
| Details | TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC |
| Chain | Residue | Details |
| A | LEU53-CYS58 | |
| site_id | PS00135 |
| Number of Residues | 12 |
| Details | TRYPSIN_SER Serine proteases, trypsin family, serine active site. DTcqGDSGGPMF |
| Chain | Residue | Details |
| A | ASP189-PHE200 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | ACT_SITE: Charge relay system |
| Chain | Residue | Details |
| A | HIS57 | |
| A | ASP102 | |
| A | GLY196 | |
| B | HIS57 | |
| B | ASP102 | |
| B | GLY196 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | SITE: Required for specificity |
| Chain | Residue | Details |
| A | THR190 | |
| B | THR190 | |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | ASP102 | |
| A | SER195 | |
| A | HIS57 | |
| site_id | CSA10 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| B | ASP102 | |
| B | SER195 | |
| B | GLY193 | |
| B | HIS57 | |
| site_id | CSA11 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | ASP102 | |
| A | SER195 | |
| A | HIS57 | |
| A | GLY196 | |
| site_id | CSA12 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| B | ASP102 | |
| B | SER195 | |
| B | HIS57 | |
| B | GLY196 | |
| site_id | CSA13 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | ASP102 | |
| A | SER195 | |
| A | GLY193 | |
| A | HIS57 | |
| A | SER214 | |
| site_id | CSA14 |
| Number of Residues | 5 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| B | ASP102 | |
| B | SER195 | |
| B | GLY193 | |
| B | HIS57 | |
| B | SER214 | |
| site_id | CSA2 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| B | ASP102 | |
| B | SER195 | |
| B | HIS57 | |
| site_id | CSA3 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | ASP102 | |
| A | HIS57 | |
| site_id | CSA4 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| B | ASP102 | |
| B | HIS57 | |
| site_id | CSA5 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | SER195 | |
| A | GLY193 | |
| site_id | CSA6 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| B | SER195 | |
| B | GLY193 | |
| site_id | CSA7 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | SER195 | |
| A | GLY196 | |
| site_id | CSA8 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| B | SER195 | |
| B | GLY196 | |
| site_id | CSA9 |
| Number of Residues | 4 |
| Details | Annotated By Reference To The Literature 1a0j |
| Chain | Residue | Details |
| A | ASP102 | |
| A | SER195 | |
| A | GLY193 | |
| A | HIS57 | |
