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3B9U

Crystal structure of L26N/D28N/H93G mutant of Human acidic fibroblast growth factor

Functional Information from GO Data
ChainGOidnamespacecontents
A0001525biological_processangiogenesis
A0001759biological_processorgan induction
A0001934biological_processpositive regulation of protein phosphorylation
A0005104molecular_functionfibroblast growth factor receptor binding
A0005178molecular_functionintegrin binding
A0005515molecular_functionprotein binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0005938cellular_componentcell cortex
A0007165biological_processsignal transduction
A0008083molecular_functiongrowth factor activity
A0008201molecular_functionheparin binding
A0008284biological_processpositive regulation of cell population proliferation
A0008543biological_processfibroblast growth factor receptor signaling pathway
A0009653biological_processanatomical structure morphogenesis
A0009887biological_processanimal organ morphogenesis
A0010595biological_processpositive regulation of endothelial cell migration
A0010628biological_processpositive regulation of gene expression
A0030154biological_processcell differentiation
A0030324biological_processlung development
A0030334biological_processregulation of cell migration
A0030335biological_processpositive regulation of cell migration
A0030544molecular_functionHsp70 protein binding
A0031012cellular_componentextracellular matrix
A0032148biological_processactivation of protein kinase B activity
A0034605biological_processcellular response to heat
A0042060biological_processwound healing
A0043406biological_processpositive regulation of MAP kinase activity
A0044548molecular_functionS100 protein binding
A0045542biological_processpositive regulation of cholesterol biosynthetic process
A0045766biological_processpositive regulation of angiogenesis
A0045944biological_processpositive regulation of transcription by RNA polymerase II
A0050673biological_processepithelial cell proliferation
A0050679biological_processpositive regulation of epithelial cell proliferation
A0051781biological_processpositive regulation of cell division
A0060681biological_processbranch elongation involved in ureteric bud branching
A0070374biological_processpositive regulation of ERK1 and ERK2 cascade
A0072163biological_processmesonephric epithelium development
A1901509biological_processregulation of endothelial tube morphogenesis
A1902533biological_processpositive regulation of intracellular signal transduction
A1903672biological_processpositive regulation of sprouting angiogenesis
A2000347biological_processpositive regulation of hepatocyte proliferation
A2000544biological_processregulation of endothelial cell chemotaxis to fibroblast growth factor
Functional Information from PDB Data
site_idAC1
Number of Residues5
DetailsBINDING SITE FOR RESIDUE SO4 A 141
ChainResidue
AASN18
ALYS112
ALYS113
ALYS118
AHOH157

Functional Information from PROSITE/UniProt
site_idPS00247
Number of Residues24
DetailsHBGF_FGF HBGF/FGF family signature. GlLyGsqtpne.EClFlErleengY
ChainResidueDetails
AGLY71-TYR94

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsBINDING: BINDING => ECO:0000269|PubMed:11069186, ECO:0000269|PubMed:9655399
ChainResidueDetails
AASN18

221716

PDB entries from 2024-06-26

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