3B8E
Crystal structure of the sodium-potassium pump
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0002028 | biological_process | regulation of sodium ion transport |
| A | 0005215 | molecular_function | transporter activity |
| A | 0005391 | molecular_function | P-type sodium:potassium-exchanging transporter activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0005890 | cellular_component | sodium:potassium-exchanging ATPase complex |
| A | 0006813 | biological_process | potassium ion transport |
| A | 0006814 | biological_process | sodium ion transport |
| A | 0006883 | biological_process | intracellular sodium ion homeostasis |
| A | 0008556 | molecular_function | P-type potassium transmembrane transporter activity |
| A | 0010248 | biological_process | establishment or maintenance of transmembrane electrochemical gradient |
| A | 0016020 | cellular_component | membrane |
| A | 0016323 | cellular_component | basolateral plasma membrane |
| A | 0016887 | molecular_function | ATP hydrolysis activity |
| A | 0030007 | biological_process | intracellular potassium ion homeostasis |
| A | 0030424 | cellular_component | axon |
| A | 0030955 | molecular_function | potassium ion binding |
| A | 0031402 | molecular_function | sodium ion binding |
| A | 0036376 | biological_process | sodium ion export across plasma membrane |
| A | 0042383 | cellular_component | sarcolemma |
| A | 0042470 | cellular_component | melanosome |
| A | 0042995 | cellular_component | cell projection |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051117 | molecular_function | ATPase binding |
| A | 0055085 | biological_process | transmembrane transport |
| A | 0086009 | biological_process | membrane repolarization |
| A | 1902600 | biological_process | proton transmembrane transport |
| A | 1990573 | biological_process | potassium ion import across plasma membrane |
| B | 0005890 | cellular_component | sodium:potassium-exchanging ATPase complex |
| B | 0006813 | biological_process | potassium ion transport |
| B | 0006814 | biological_process | sodium ion transport |
| C | 0000166 | molecular_function | nucleotide binding |
| C | 0002028 | biological_process | regulation of sodium ion transport |
| C | 0005215 | molecular_function | transporter activity |
| C | 0005391 | molecular_function | P-type sodium:potassium-exchanging transporter activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0005890 | cellular_component | sodium:potassium-exchanging ATPase complex |
| C | 0006813 | biological_process | potassium ion transport |
| C | 0006814 | biological_process | sodium ion transport |
| C | 0006883 | biological_process | intracellular sodium ion homeostasis |
| C | 0008556 | molecular_function | P-type potassium transmembrane transporter activity |
| C | 0010248 | biological_process | establishment or maintenance of transmembrane electrochemical gradient |
| C | 0016020 | cellular_component | membrane |
| C | 0016323 | cellular_component | basolateral plasma membrane |
| C | 0016887 | molecular_function | ATP hydrolysis activity |
| C | 0030007 | biological_process | intracellular potassium ion homeostasis |
| C | 0030424 | cellular_component | axon |
| C | 0030955 | molecular_function | potassium ion binding |
| C | 0031402 | molecular_function | sodium ion binding |
| C | 0036376 | biological_process | sodium ion export across plasma membrane |
| C | 0042383 | cellular_component | sarcolemma |
| C | 0042470 | cellular_component | melanosome |
| C | 0042995 | cellular_component | cell projection |
| C | 0046872 | molecular_function | metal ion binding |
| C | 0051117 | molecular_function | ATPase binding |
| C | 0055085 | biological_process | transmembrane transport |
| C | 0086009 | biological_process | membrane repolarization |
| C | 1902600 | biological_process | proton transmembrane transport |
| C | 1990573 | biological_process | potassium ion import across plasma membrane |
| D | 0005890 | cellular_component | sodium:potassium-exchanging ATPase complex |
| D | 0006813 | biological_process | potassium ion transport |
| D | 0006814 | biological_process | sodium ion transport |
| G | 0016020 | cellular_component | membrane |
| G | 0043269 | biological_process | regulation of monoatomic ion transport |
| G | 0099106 | molecular_function | ion channel regulator activity |
| H | 0016020 | cellular_component | membrane |
| H | 0043269 | biological_process | regulation of monoatomic ion transport |
| H | 0099106 | molecular_function | ion channel regulator activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG A 2002 |
| Chain | Residue |
| A | GLY213 |
| A | ASP369 |
| A | THR371 |
| A | ASP710 |
| A | MF42001 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE RB A 2003 |
| Chain | Residue |
| A | ASP804 |
| A | THR772 |
| A | SER775 |
| A | ASN776 |
| A | GLU779 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE RB A 2004 |
| Chain | Residue |
| A | VAL322 |
| A | ASN324 |
| A | VAL325 |
| A | GLU327 |
| A | ASN776 |
| A | GLU779 |
| A | ASP804 |
| site_id | AC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE RB A 2005 |
| Chain | Residue |
| A | ASP740 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG C 2002 |
| Chain | Residue |
| C | GLY213 |
| C | ASP369 |
| C | THR371 |
| C | ASP710 |
| C | MF42001 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE RB C 2003 |
| Chain | Residue |
| C | THR772 |
| C | SER775 |
| C | ASN776 |
| C | GLU779 |
| C | ASP804 |
| site_id | AC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE RB C 2004 |
| Chain | Residue |
| C | VAL322 |
| C | VAL325 |
| C | GLU327 |
| C | ASN776 |
| C | GLU779 |
| C | ASP804 |
| site_id | AC8 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE RB C 2005 |
| Chain | Residue |
| C | ASP740 |
| site_id | AC9 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE MF4 A 2001 |
| Chain | Residue |
| A | THR212 |
| A | GLY213 |
| A | GLU214 |
| A | ASP369 |
| A | LYS370 |
| A | THR371 |
| A | VAL609 |
| A | THR610 |
| A | GLY611 |
| A | ASP612 |
| A | LYS691 |
| A | ASN713 |
| A | MG2002 |
| site_id | BC1 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE MF4 C 2001 |
| Chain | Residue |
| C | THR212 |
| C | GLY213 |
| C | GLU214 |
| C | ASP369 |
| C | LYS370 |
| C | THR371 |
| C | VAL609 |
| C | THR610 |
| C | GLY611 |
| C | ASP612 |
| C | LYS691 |
| C | ASN713 |
| C | MG2002 |
| site_id | BC2 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE PC1 B 1 |
| Chain | Residue |
| B | TYR43 |
| site_id | BC3 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE PC1 C 1 |
| Chain | Residue |
| C | GLY848 |
| D | TYR39 |
| D | TYR43 |
Functional Information from PROSITE/UniProt
| site_id | PS00154 |
| Number of Residues | 7 |
| Details | ATPASE_E1_E2 E1-E2 ATPases phosphorylation site. DKTGTLT |
| Chain | Residue | Details |
| A | ASP369-THR375 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 54 |
| Details | TRANSMEM: Helical; Signal-anchor for type II membrane protein => ECO:0000255 |
| Chain | Residue | Details |
| B | ILE35-SER62 | |
| A | ALA984-ARG1004 | |
| C | CYS86-LEU106 | |
| C | SER130-ILE150 | |
| C | ILE287-LEU306 | |
| C | GLY319-CYS336 | |
| C | TYR771-ASN790 | |
| C | LEU801-GLU821 | |
| C | LEU842-VAL864 | |
| C | VAL917-SER936 | |
| C | GLY950-GLY968 | |
| D | ILE35-SER62 | |
| C | ALA984-ARG1004 | |
| A | ILE287-LEU306 | |
| A | GLY319-CYS336 | |
| A | TYR771-ASN790 | |
| A | LEU801-GLU821 | |
| A | LEU842-VAL864 | |
| A | VAL917-SER936 | |
| A | GLY950-GLY968 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 214 |
| Details | TOPO_DOM: Extracellular => ECO:0000255 |
| Chain | Residue | Details |
| A | ALA107-LEU129 | |
| C | VAL969-CYS983 | |
| A | GLU307-ILE318 | |
| A | ILE791-ILE800 | |
| A | ILE865-PHE916 | |
| A | VAL969-CYS983 | |
| C | ALA107-LEU129 | |
| C | GLU307-ILE318 | |
| C | ILE791-ILE800 | |
| C | ILE865-PHE916 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1198 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| A | MET151-HIS286 | |
| A | LEU337-ALA770 | |
| A | SER822-GLN841 | |
| A | VAL937-PHE949 | |
| C | MET151-HIS286 | |
| C | LEU337-ALA770 | |
| C | SER822-GLN841 | |
| C | VAL937-PHE949 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | ACT_SITE: 4-aspartylphosphate intermediate => ECO:0000250 |
| Chain | Residue | Details |
| A | LEU374 | |
| C | LEU374 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | ILE485 | |
| A | SER715 | |
| A | LYS719 | |
| C | ILE485 | |
| C | SER715 | |
| C | LYS719 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q8VDN2 |
| Chain | Residue | Details |
| A | LYS21 | |
| C | LYS21 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 8 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P06685 |
| Chain | Residue | Details |
| A | LYS38 | |
| A | HIS45 | |
| A | LEU450 | |
| A | GLN482 | |
| C | LYS38 | |
| C | HIS45 | |
| C | LEU450 | |
| C | GLN482 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 6 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q8VDN2 |
| Chain | Residue | Details |
| A | ASN226 | |
| A | MET666 | |
| A | ASP673 | |
| C | ASN226 | |
| C | MET666 | |
| C | ASP673 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:Q8VDN2 |
| Chain | Residue | Details |
| A | THR258 | |
| C | THR258 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P05023 |
| Chain | Residue | Details |
| A | GLY540 | |
| C | GLY540 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 2 |
| Details | MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q8VDN2 |
| Chain | Residue | Details |
| A | HIS659 | |
| C | HIS659 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine; by PKA => ECO:0000250|UniProtKB:P06685 |
| Chain | Residue | Details |
| A | GLY941 | |
| C | GLY941 |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1su4 |
| Chain | Residue | Details |
| A | ASP369 |
| site_id | CSA2 |
| Number of Residues | 1 |
| Details | Annotated By Reference To The Literature 1su4 |
| Chain | Residue | Details |
| C | ASP369 |
