Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3B8E

Crystal structure of the sodium-potassium pump

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0002028	biological_process	regulation of sodium ion transport
A	0005215	molecular_function	transporter activity
A	0005391	molecular_function	P-type sodium:potassium-exchanging transporter activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005886	cellular_component	plasma membrane
A	0005890	cellular_component	sodium:potassium-exchanging ATPase complex
A	0006811	biological_process	monoatomic ion transport
A	0006813	biological_process	potassium ion transport
A	0006814	biological_process	sodium ion transport
A	0006883	biological_process	intracellular sodium ion homeostasis
A	0008556	molecular_function	P-type potassium transmembrane transporter activity
A	0010248	biological_process	establishment or maintenance of transmembrane electrochemical gradient
A	0016020	cellular_component	membrane
A	0016323	cellular_component	basolateral plasma membrane
A	0016887	molecular_function	ATP hydrolysis activity
A	0030007	biological_process	intracellular potassium ion homeostasis
A	0030424	cellular_component	axon
A	0030955	molecular_function	potassium ion binding
A	0031402	molecular_function	sodium ion binding
A	0036376	biological_process	sodium ion export across plasma membrane
A	0042383	cellular_component	sarcolemma
A	0042470	cellular_component	melanosome
A	0046872	molecular_function	metal ion binding
A	0051117	molecular_function	ATPase binding
A	0055085	biological_process	transmembrane transport
A	0071805	biological_process	potassium ion transmembrane transport
A	0086009	biological_process	membrane repolarization
A	0090533	cellular_component	cation-transporting ATPase complex
A	0098797	cellular_component	plasma membrane protein complex
A	1902600	biological_process	proton transmembrane transport
A	1990573	biological_process	potassium ion import across plasma membrane
B	0005890	cellular_component	sodium:potassium-exchanging ATPase complex
B	0006813	biological_process	potassium ion transport
B	0006814	biological_process	sodium ion transport
C	0000166	molecular_function	nucleotide binding
C	0002028	biological_process	regulation of sodium ion transport
C	0005215	molecular_function	transporter activity
C	0005391	molecular_function	P-type sodium:potassium-exchanging transporter activity
C	0005515	molecular_function	protein binding
C	0005524	molecular_function	ATP binding
C	0005886	cellular_component	plasma membrane
C	0005890	cellular_component	sodium:potassium-exchanging ATPase complex
C	0006811	biological_process	monoatomic ion transport
C	0006813	biological_process	potassium ion transport
C	0006814	biological_process	sodium ion transport
C	0006883	biological_process	intracellular sodium ion homeostasis
C	0008556	molecular_function	P-type potassium transmembrane transporter activity
C	0010248	biological_process	establishment or maintenance of transmembrane electrochemical gradient
C	0016020	cellular_component	membrane
C	0016323	cellular_component	basolateral plasma membrane
C	0016887	molecular_function	ATP hydrolysis activity
C	0030007	biological_process	intracellular potassium ion homeostasis
C	0030424	cellular_component	axon
C	0030955	molecular_function	potassium ion binding
C	0031402	molecular_function	sodium ion binding
C	0036376	biological_process	sodium ion export across plasma membrane
C	0042383	cellular_component	sarcolemma
C	0042470	cellular_component	melanosome
C	0046872	molecular_function	metal ion binding
C	0051117	molecular_function	ATPase binding
C	0055085	biological_process	transmembrane transport
C	0071805	biological_process	potassium ion transmembrane transport
C	0086009	biological_process	membrane repolarization
C	0090533	cellular_component	cation-transporting ATPase complex
C	0098797	cellular_component	plasma membrane protein complex
C	1902600	biological_process	proton transmembrane transport
C	1990573	biological_process	potassium ion import across plasma membrane
D	0005890	cellular_component	sodium:potassium-exchanging ATPase complex
D	0006813	biological_process	potassium ion transport
D	0006814	biological_process	sodium ion transport
G	0016020	cellular_component	membrane
G	0043269	biological_process	regulation of monoatomic ion transport
G	0099106	molecular_function	ion channel regulator activity
H	0016020	cellular_component	membrane
H	0043269	biological_process	regulation of monoatomic ion transport
H	0099106	molecular_function	ion channel regulator activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG A 2002

Chain	Residue
A	GLY213
A	ASP369
A	THR371
A	ASP710
A	MF42001

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE RB A 2003

Chain	Residue
A	ASP804
A	THR772
A	SER775
A	ASN776
A	GLU779

site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE RB A 2004

Chain	Residue
A	VAL322
A	ASN324
A	VAL325
A	GLU327
A	ASN776
A	GLU779
A	ASP804

site_id	AC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE RB A 2005

Chain	Residue
A	ASP740

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG C 2002

Chain	Residue
C	GLY213
C	ASP369
C	THR371
C	ASP710
C	MF42001

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE RB C 2003

Chain	Residue
C	THR772
C	SER775
C	ASN776
C	GLU779
C	ASP804

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE RB C 2004

Chain	Residue
C	VAL322
C	VAL325
C	GLU327
C	ASN776
C	GLU779
C	ASP804

site_id	AC8
Number of Residues	1
Details	BINDING SITE FOR RESIDUE RB C 2005

Chain	Residue
C	ASP740

site_id	AC9
Number of Residues	13
Details	BINDING SITE FOR RESIDUE MF4 A 2001

Chain	Residue
A	THR212
A	GLY213
A	GLU214
A	ASP369
A	LYS370
A	THR371
A	VAL609
A	THR610
A	GLY611
A	ASP612
A	LYS691
A	ASN713
A	MG2002

site_id	BC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE MF4 C 2001

Chain	Residue
C	THR212
C	GLY213
C	GLU214
C	ASP369
C	LYS370
C	THR371
C	VAL609
C	THR610
C	GLY611
C	ASP612
C	LYS691
C	ASN713
C	MG2002

site_id	BC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE PC1 B 1

Chain	Residue
B	TYR43

site_id	BC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PC1 C 1

Chain	Residue
C	GLY848
D	TYR39
D	TYR43

Functional Information from PROSITE/UniProt

site_id	PS00154
Number of Residues	7
Details	ATPASE_E1_E2 E1-E2 ATPases phosphorylation site. DKTGTLT

Chain	Residue	Details
A	ASP369-THR375

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	388
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	214
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	1230
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	4
Details	Region: {"description":"Phosphoinositide-3 kinase binding","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	38
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	242
Details	Region: {"description":"Mediates interaction with SCN7A","evidences":[{"source":"UniProtKB","id":"Q8VDN2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	22
Details	Compositional bias: {"description":"Basic and acidic residues","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	2
Details	Active site: {"description":"4-aspartylphosphate intermediate","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	6
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P06685","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	6
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q8VDN2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"Q8VDN2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"UniProtKB","id":"P05023","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI14
Number of Residues	2
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q8VDN2","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI15
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; by PKA","evidences":[{"source":"UniProtKB","id":"P06685","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI16
Number of Residues	54
Details	Transmembrane: {"description":"Helical; Signal-anchor for type II membrane protein","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

Catalytic Information from CSA

site_id	CSA1
Number of Residues	1
Details	Annotated By Reference To The Literature 1su4

Chain	Residue	Details
A	ASP369

site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1su4

Chain	Residue	Details
C	ASP369

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)