3B8A
Crystal structure of yeast hexokinase PI in complex with glucose
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| X | 0000166 | molecular_function | nucleotide binding |
| X | 0001678 | biological_process | intracellular glucose homeostasis |
| X | 0003824 | molecular_function | catalytic activity |
| X | 0004340 | molecular_function | glucokinase activity |
| X | 0004396 | molecular_function | hexokinase activity |
| X | 0005515 | molecular_function | protein binding |
| X | 0005524 | molecular_function | ATP binding |
| X | 0005536 | molecular_function | D-glucose binding |
| X | 0005737 | cellular_component | cytoplasm |
| X | 0005739 | cellular_component | mitochondrion |
| X | 0005829 | cellular_component | cytosol |
| X | 0005975 | biological_process | carbohydrate metabolic process |
| X | 0006000 | biological_process | fructose metabolic process |
| X | 0006006 | biological_process | glucose metabolic process |
| X | 0006013 | biological_process | mannose metabolic process |
| X | 0006096 | biological_process | glycolytic process |
| X | 0008865 | molecular_function | fructokinase activity |
| X | 0016301 | molecular_function | kinase activity |
| X | 0016740 | molecular_function | transferase activity |
| X | 0016773 | molecular_function | phosphotransferase activity, alcohol group as acceptor |
| X | 0019158 | molecular_function | mannokinase activity |
| X | 0019318 | biological_process | hexose metabolic process |
| X | 0046323 | biological_process | D-glucose import |
| X | 0046835 | biological_process | carbohydrate phosphorylation |
| X | 0051156 | biological_process | glucose 6-phosphate metabolic process |
| X | 1990539 | biological_process | fructose import across plasma membrane |
Functional Information from PROSITE/UniProt
| site_id | PS00378 |
| Number of Residues | 26 |
| Details | HEXOKINASE_1 Hexokinase domain signature. LGFTFSYPasqnkINegiLqrWTKgF |
| Chain | Residue | Details |
| X | LEU153-PHE178 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 247 |
| Details | Region: {"description":"Hexokinase large subdomain","evidences":[{"source":"PROSITE-ProRule","id":"PRU01084","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 14 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 6 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 3 |
| Details | Annotated By Reference To The Literature 1ig8 |
| Chain | Residue | Details |
| X | ASP211 | |
| X | SER158 | |
| X | ARG173 |
