3B7D

Crystal structure of the GLUR2 ligand binding core (HS1S2J) in complex with CNQX at 2.5 A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane
C	0015276	molecular_function	ligand-gated monoatomic ion channel activity
C	0016020	cellular_component	membrane
D	0015276	molecular_function	ligand-gated monoatomic ion channel activity
D	0016020	cellular_component	membrane
E	0015276	molecular_function	ligand-gated monoatomic ion channel activity
E	0016020	cellular_component	membrane
F	0015276	molecular_function	ligand-gated monoatomic ion channel activity
F	0016020	cellular_component	membrane
G	0015276	molecular_function	ligand-gated monoatomic ion channel activity
G	0016020	cellular_component	membrane
H	0015276	molecular_function	ligand-gated monoatomic ion channel activity
H	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE CNI D 262

Chain	Residue
D	GLU13
D	HOH288
D	HOH297
D	TYR61
D	PRO89
D	LEU90
D	THR91
D	ARG96
D	THR174
D	GLU193
D	TYR220

---

site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE CNI C 262

Chain	Residue
C	TYR61
C	PRO89
C	LEU90
C	THR91
C	ARG96
C	THR174
C	GLU193
C	MET196
C	TYR220

---

site_id	AC3
Number of Residues	12
Details	BINDING SITE FOR RESIDUE CNI F 262

Chain	Residue
F	GLU13
F	TYR61
F	PRO89
F	LEU90
F	THR91
F	ARG96
F	THR174
F	GLU193
F	MET196
F	TYR220
F	HOH286
F	HOH315

---

site_id	AC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE CNI A 262

Chain	Residue
A	TYR61
A	PRO89
A	LEU90
A	THR91
A	ARG96
A	THR174
A	GLU193
A	TYR220
A	HOH273

---

site_id	AC5
Number of Residues	13
Details	BINDING SITE FOR RESIDUE CNI G 262

Chain	Residue
G	GLU13
G	TYR61
G	PRO89
G	LEU90
G	THR91
G	ARG96
G	SER142
G	THR174
G	GLU193
G	MET196
G	TYR220
G	HOH278
G	HOH299

---

site_id	AC6
Number of Residues	10
Details	BINDING SITE FOR RESIDUE CNI B 262

Chain	Residue
B	GLU13
B	TYR61
B	PRO89
B	THR91
B	ARG96
B	THR174
B	GLU193
B	TYR220
B	HOH284
B	HOH350

---

site_id	AC7
Number of Residues	11
Details	BINDING SITE FOR RESIDUE CNI H 262

Chain	Residue
H	GLU13
H	TYR61
H	PRO89
H	THR91
H	ARG96
H	THR174
H	GLU193
H	MET196
H	TYR220
H	HOH328
H	HOH329

---

site_id	AC8
Number of Residues	12
Details	BINDING SITE FOR RESIDUE CNI E 262

Chain	Residue
E	GLU13
E	TYR61
E	PRO89
E	THR91
E	ARG96
E	SER142
E	THR174
E	GLU193
E	MET196
E	TYR220
E	HOH296
E	HOH331

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	48
Details	BINDING: BINDING => ECO:0000269|PubMed:11086992, ECO:0000269|PubMed:16483599, ECO:0007744|PDB:1FTJ, ECO:0007744|PDB:2CMO

Chain	Residue	Details
A	PRO89
B	SER142
B	THR143
B	GLU193
C	PRO89
C	THR91
C	ARG96
C	SER142
C	THR143
C	GLU193
D	PRO89
A	THR91
D	THR91
D	ARG96
D	SER142
D	THR143
D	GLU193
E	PRO89
E	THR91
E	ARG96
E	SER142
E	THR143
A	ARG96
E	GLU193
F	PRO89
F	THR91
F	ARG96
F	SER142
F	THR143
F	GLU193
G	PRO89
G	THR91
G	ARG96
A	SER142
G	SER142
G	THR143
G	GLU193
H	PRO89
H	THR91
H	ARG96
H	SER142
H	THR143
H	GLU193
A	THR143
A	GLU193
B	PRO89
B	THR91
B	ARG96

---

site_id	SWS_FT_FI2
Number of Residues	24
Details	SITE: Interaction with the cone snail toxin Con-ikot-ikot => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	ARG64
D	ARG64
D	ARG148
D	LYS240
E	ARG64
E	ARG148
E	LYS240
F	ARG64
F	ARG148
F	LYS240
G	ARG64
A	ARG148
G	ARG148
G	LYS240
H	ARG64
H	ARG148
H	LYS240
A	LYS240
B	ARG64
B	ARG148
B	LYS240
C	ARG64
C	ARG148
C	LYS240

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	SITE: Crucial to convey clamshell closure to channel opening => ECO:0000269|PubMed:25103405

Chain	Residue	Details
A	ILE121
B	ILE121
C	ILE121
D	ILE121
E	ILE121
F	ILE121
G	ILE121
H	ILE121

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	MOD_RES: Phosphoserine; by PKC => ECO:0000269|PubMed:8848293

Chain	Residue	Details
A	SER150
B	SER150
C	SER150
D	SER150
E	SER150
F	SER150
G	SER150
H	SER150

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	MOD_RES: Phosphoserine; by PKG => ECO:0000269|PubMed:8848293

Chain	Residue	Details
A	SER184
B	SER184
C	SER184
D	SER184
E	SER184
F	SER184
G	SER184
H	SER184

---

site_id	SWS_FT_FI6
Number of Residues	8
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN3
B	ASN3
C	ASN3
D	ASN3
E	ASN3
F	ASN3
G	ASN3
H	ASN3

---