3B7D

Crystal structure of the GLUR2 ligand binding core (HS1S2J) in complex with CNQX at 2.5 A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0015276	molecular_function	ligand-gated monoatomic ion channel activity
A	0016020	cellular_component	membrane
B	0015276	molecular_function	ligand-gated monoatomic ion channel activity
B	0016020	cellular_component	membrane
C	0015276	molecular_function	ligand-gated monoatomic ion channel activity
C	0016020	cellular_component	membrane
D	0015276	molecular_function	ligand-gated monoatomic ion channel activity
D	0016020	cellular_component	membrane
E	0015276	molecular_function	ligand-gated monoatomic ion channel activity
E	0016020	cellular_component	membrane
F	0015276	molecular_function	ligand-gated monoatomic ion channel activity
F	0016020	cellular_component	membrane
G	0015276	molecular_function	ligand-gated monoatomic ion channel activity
G	0016020	cellular_component	membrane
H	0015276	molecular_function	ligand-gated monoatomic ion channel activity
H	0016020	cellular_component	membrane

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE CNI D 262

Chain	Residue
D	GLU13
D	HOH288
D	HOH297
D	TYR61
D	PRO89
D	LEU90
D	THR91
D	ARG96
D	THR174
D	GLU193
D	TYR220

---

site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE CNI C 262

Chain	Residue
C	TYR61
C	PRO89
C	LEU90
C	THR91
C	ARG96
C	THR174
C	GLU193
C	MET196
C	TYR220

---

site_id	AC3
Number of Residues	12
Details	BINDING SITE FOR RESIDUE CNI F 262

Chain	Residue
F	GLU13
F	TYR61
F	PRO89
F	LEU90
F	THR91
F	ARG96
F	THR174
F	GLU193
F	MET196
F	TYR220
F	HOH286
F	HOH315

---

site_id	AC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE CNI A 262

Chain	Residue
A	TYR61
A	PRO89
A	LEU90
A	THR91
A	ARG96
A	THR174
A	GLU193
A	TYR220
A	HOH273

---

site_id	AC5
Number of Residues	13
Details	BINDING SITE FOR RESIDUE CNI G 262

Chain	Residue
G	GLU13
G	TYR61
G	PRO89
G	LEU90
G	THR91
G	ARG96
G	SER142
G	THR174
G	GLU193
G	MET196
G	TYR220
G	HOH278
G	HOH299

---

site_id	AC6
Number of Residues	10
Details	BINDING SITE FOR RESIDUE CNI B 262

Chain	Residue
B	GLU13
B	TYR61
B	PRO89
B	THR91
B	ARG96
B	THR174
B	GLU193
B	TYR220
B	HOH284
B	HOH350

---

site_id	AC7
Number of Residues	11
Details	BINDING SITE FOR RESIDUE CNI H 262

Chain	Residue
H	GLU13
H	TYR61
H	PRO89
H	THR91
H	ARG96
H	THR174
H	GLU193
H	MET196
H	TYR220
H	HOH328
H	HOH329

---

site_id	AC8
Number of Residues	12
Details	BINDING SITE FOR RESIDUE CNI E 262

Chain	Residue
E	GLU13
E	TYR61
E	PRO89
E	THR91
E	ARG96
E	SER142
E	THR174
E	GLU193
E	MET196
E	TYR220
E	HOH296
E	HOH331

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	48
Details	Binding site: {"evidences":[{"source":"PubMed","id":"11086992","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16483599","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FTJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CMO","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	24
Details	Site: {"description":"Interaction with the cone snail toxin Con-ikot-ikot","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Site: {"description":"Crucial to convey clamshell closure to channel opening","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine; by PKC","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	8
Details	Modified residue: {"description":"Phosphoserine; by PKG","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---