3B54

Saccharomyces cerevisiae nucleoside diphosphate kinase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004550	molecular_function	nucleoside diphosphate kinase activity
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005758	cellular_component	mitochondrial intermembrane space
A	0005829	cellular_component	cytosol
A	0006164	biological_process	purine nucleotide biosynthetic process
A	0006183	biological_process	GTP biosynthetic process
A	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
A	0006228	biological_process	UTP biosynthetic process
A	0006241	biological_process	CTP biosynthetic process
A	0006974	biological_process	DNA damage response
A	0009142	biological_process	nucleoside triphosphate biosynthetic process
A	0009165	biological_process	nucleotide biosynthetic process
A	0009220	biological_process	pyrimidine ribonucleotide biosynthetic process
A	0010138	biological_process	pyrimidine ribonucleotide salvage
A	0043101	biological_process	purine-containing compound salvage
A	0046085	biological_process	adenosine metabolic process
A	0046086	biological_process	adenosine biosynthetic process
A	0106387	biological_process	'de novo' GMP biosynthetic process
B	0004550	molecular_function	nucleoside diphosphate kinase activity
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005758	cellular_component	mitochondrial intermembrane space
B	0005829	cellular_component	cytosol
B	0006164	biological_process	purine nucleotide biosynthetic process
B	0006183	biological_process	GTP biosynthetic process
B	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
B	0006228	biological_process	UTP biosynthetic process
B	0006241	biological_process	CTP biosynthetic process
B	0006974	biological_process	DNA damage response
B	0009142	biological_process	nucleoside triphosphate biosynthetic process
B	0009165	biological_process	nucleotide biosynthetic process
B	0009220	biological_process	pyrimidine ribonucleotide biosynthetic process
B	0010138	biological_process	pyrimidine ribonucleotide salvage
B	0043101	biological_process	purine-containing compound salvage
B	0046085	biological_process	adenosine metabolic process
B	0046086	biological_process	adenosine biosynthetic process
B	0106387	biological_process	'de novo' GMP biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE PO4 A 154

Chain	Residue
A	ARG89
A	ARG106
A	HIS119

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE PO4 B 154

Chain	Residue
B	ARG89
B	ARG106
B	HIS119
B	GLY120

---

Functional Information from PROSITE/UniProt

site_id	PS00469
Number of Residues	9
Details	NDPK Nucleoside diphosphate kinase (NDPK) active site signature. NvcHGSDSV

Chain	Residue	Details
A	ASN116-VAL124

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Pros-phosphohistidine intermediate","evidences":[{"source":"UniProtKB","id":"P22392","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P22392","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Modified residue: {"description":"Phosphothreonine","evidences":[{"source":"PubMed","id":"18407956","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1nsp

Chain	Residue	Details
A	LYS13
A	ASN116

---

site_id	CSA2
Number of Residues	2
Details	Annotated By Reference To The Literature 1nsp

Chain	Residue	Details
B	LYS13
B	ASN116

---

site_id	CSA3
Number of Residues	2
Details	Annotated By Reference To The Literature 1nsp

Chain	Residue	Details
A	LYS13
A	TYR53

---

site_id	CSA4
Number of Residues	2
Details	Annotated By Reference To The Literature 1nsp

Chain	Residue	Details
B	LYS13
B	TYR53

---