Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

3B20

Crystal structure of Glyceraldehyde-3-Phosphate Dehydrogenase complexed with NADfrom Synechococcus elongatus"

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0006006	biological_process	glucose metabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
A	0043891	molecular_function	glyceraldehyde-3-phosphate dehydrogenase [NAD(P)+] (phosphorylating) activity
A	0046872	molecular_function	metal ion binding
A	0050661	molecular_function	NADP binding
A	0051287	molecular_function	NAD binding
B	0000166	molecular_function	nucleotide binding
B	0006006	biological_process	glucose metabolic process
B	0016491	molecular_function	oxidoreductase activity
B	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
B	0043891	molecular_function	glyceraldehyde-3-phosphate dehydrogenase [NAD(P)+] (phosphorylating) activity
B	0046872	molecular_function	metal ion binding
B	0050661	molecular_function	NADP binding
B	0051287	molecular_function	NAD binding
O	0000166	molecular_function	nucleotide binding
O	0006006	biological_process	glucose metabolic process
O	0016491	molecular_function	oxidoreductase activity
O	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
O	0043891	molecular_function	glyceraldehyde-3-phosphate dehydrogenase [NAD(P)+] (phosphorylating) activity
O	0046872	molecular_function	metal ion binding
O	0050661	molecular_function	NADP binding
O	0051287	molecular_function	NAD binding
P	0000166	molecular_function	nucleotide binding
P	0006006	biological_process	glucose metabolic process
P	0016491	molecular_function	oxidoreductase activity
P	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
P	0043891	molecular_function	glyceraldehyde-3-phosphate dehydrogenase [NAD(P)+] (phosphorylating) activity
P	0046872	molecular_function	metal ion binding
P	0050661	molecular_function	NADP binding
P	0051287	molecular_function	NAD binding
Q	0000166	molecular_function	nucleotide binding
Q	0006006	biological_process	glucose metabolic process
Q	0016491	molecular_function	oxidoreductase activity
Q	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
Q	0043891	molecular_function	glyceraldehyde-3-phosphate dehydrogenase [NAD(P)+] (phosphorylating) activity
Q	0046872	molecular_function	metal ion binding
Q	0050661	molecular_function	NADP binding
Q	0051287	molecular_function	NAD binding
R	0000166	molecular_function	nucleotide binding
R	0006006	biological_process	glucose metabolic process
R	0016491	molecular_function	oxidoreductase activity
R	0016620	molecular_function	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
R	0043891	molecular_function	glyceraldehyde-3-phosphate dehydrogenase [NAD(P)+] (phosphorylating) activity
R	0046872	molecular_function	metal ion binding
R	0050661	molecular_function	NADP binding
R	0051287	molecular_function	NAD binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 A 1339

Chain	Residue
A	SER154
A	THR156
A	THR213
A	GLY214
A	ALA215
A	HOH361
A	HOH380
A	HOH399

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 1340

Chain	Residue
A	ASP187
A	ARG200
A	ARG236
A	NAD340
A	THR185

site_id	AC3
Number of Residues	22
Details	BINDING SITE FOR RESIDUE NAD A 340

Chain	Residue
A	GLY9
A	GLY11
A	ARG12
A	ILE13
A	ASN35
A	ASN36
A	THR37
A	ARG80
A	SER98
A	THR99
A	GLY100
A	THR122
A	ALA123
A	CYS155
A	LEU186
A	ASN318
A	HOH352
A	HOH404
A	HOH417
A	HOH422
A	SO41340
B	HOH413

site_id	AC4
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 B 2339

Chain	Residue
B	SER154
B	THR213
B	GLY214
B	ALA215
B	HOH347
B	HOH377
B	HOH442

site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 B 2340

Chain	Residue
B	THR185
B	ASP187
B	ARG200
B	ARG236
B	NAD340
B	HOH374
B	HOH377

site_id	AC6
Number of Residues	24
Details	BINDING SITE FOR RESIDUE NAD B 340

Chain	Residue
B	GLY9
B	PHE10
B	GLY11
B	ARG12
B	ILE13
B	ASN35
B	ASN36
B	THR37
B	ARG80
B	THR99
B	GLY100
B	THR122
B	ALA123
B	CYS155
B	LEU186
B	ASN318
B	TYR322
B	HOH374
B	HOH378
B	HOH412
B	HOH418
B	HOH419
B	HOH436
B	SO42340

site_id	AC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE SO4 O 3339

Chain	Residue
O	SER154
O	THR156
O	THR213
O	GLY214
O	ALA215
O	HOH362
O	HOH397
O	HOH419

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 O 3340

Chain	Residue
O	THR185
O	ASP187
O	ARG200
O	ARG236
O	NAD340

site_id	AC9
Number of Residues	21
Details	BINDING SITE FOR RESIDUE NAD O 340

Chain	Residue
O	LEU186
O	ASN318
O	GLU319
O	HOH389
O	HOH410
O	HOH413
O	HOH417
O	SO43340
O	PHE10
O	GLY11
O	ARG12
O	ILE13
O	ASN36
O	THR37
O	ARG80
O	SER98
O	THR99
O	GLY100
O	THR122
O	ALA123
O	CYS155

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 P 4339

Chain	Residue
P	SER154
P	THR156
P	THR213
P	GLY214

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 P 4340

Chain	Residue
P	THR185
P	ASP187
P	ARG200
P	ARG236
P	NAD340
P	HOH398

site_id	BC3
Number of Residues	23
Details	BINDING SITE FOR RESIDUE NAD P 340

Chain	Residue
P	GLY9
P	PHE10
P	GLY11
P	ARG12
P	ILE13
P	ASN35
P	ASN36
P	THR37
P	ARG80
P	THR99
P	GLY100
P	THR122
P	ALA123
P	CYS155
P	THR185
P	LEU186
P	ASN318
P	GLU319
P	TYR322
P	HOH371
P	HOH382
P	HOH388
P	SO44340

site_id	BC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 Q 5339

Chain	Residue
Q	SER154
Q	THR156
Q	THR213
Q	GLY214
Q	ALA215

site_id	BC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 Q 5340

Chain	Residue
Q	THR185
Q	ASP187
Q	ARG200
Q	ARG236
Q	NAD340

site_id	BC6
Number of Residues	19
Details	BINDING SITE FOR RESIDUE NAD Q 340

Chain	Residue
Q	GLY9
Q	GLY11
Q	ARG12
Q	ILE13
Q	ASN35
Q	THR37
Q	ARG80
Q	SER98
Q	THR99
Q	GLY100
Q	THR122
Q	ALA123
Q	CYS155
Q	THR185
Q	LEU186
Q	ASN318
Q	GLU319
Q	HOH357
Q	SO45340

site_id	BC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 R 6339

Chain	Residue
R	SER154
R	THR213
R	ALA215

site_id	BC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 R 6340

Chain	Residue
R	THR185
R	ARG200
R	ARG236
R	NAD340

site_id	BC9
Number of Residues	20
Details	BINDING SITE FOR RESIDUE NAD R 340

Chain	Residue
R	GLY9
R	GLY11
R	ARG12
R	ILE13
R	THR37
R	ARG80
R	SER98
R	THR99
R	GLY100
R	THR122
R	ALA123
R	CYS155
R	THR185
R	LEU186
R	ASN318
R	GLU319
R	TYR322
R	HOH357
R	HOH365
R	SO46340

Functional Information from PROSITE/UniProt

site_id	PS00071
Number of Residues	8
Details	GAPDH Glyceraldehyde 3-phosphate dehydrogenase active site. ASCTTNcL

Chain	Residue	Details
A	ALA153-LEU160

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)