3B0P
tRNA-dihydrouridine synthase from Thermus thermophilus
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000049 | molecular_function | tRNA binding |
A | 0000166 | molecular_function | nucleotide binding |
A | 0002943 | biological_process | tRNA dihydrouridine synthesis |
A | 0008033 | biological_process | tRNA processing |
A | 0010181 | molecular_function | FMN binding |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0017150 | molecular_function | tRNA dihydrouridine synthase activity |
A | 0050660 | molecular_function | flavin adenine dinucleotide binding |
A | 0102264 | molecular_function | tRNA-dihydrouridine20 synthase activity |
A | 0102266 | molecular_function | tRNA-dihydrouridine20a synthase activity |
B | 0000049 | molecular_function | tRNA binding |
B | 0000166 | molecular_function | nucleotide binding |
B | 0002943 | biological_process | tRNA dihydrouridine synthesis |
B | 0008033 | biological_process | tRNA processing |
B | 0010181 | molecular_function | FMN binding |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0017150 | molecular_function | tRNA dihydrouridine synthase activity |
B | 0050660 | molecular_function | flavin adenine dinucleotide binding |
B | 0102264 | molecular_function | tRNA-dihydrouridine20 synthase activity |
B | 0102266 | molecular_function | tRNA-dihydrouridine20a synthase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 18 |
Details | BINDING SITE FOR RESIDUE FMN A 351 |
Chain | Residue |
A | ALA9 |
A | HIS164 |
A | ASN203 |
A | GLY204 |
A | GLY205 |
A | GLY225 |
A | ARG226 |
A | HOH357 |
A | HOH394 |
A | HOH396 |
A | PRO10 |
A | MET11 |
A | VAL12 |
A | ARG14 |
A | MET36 |
A | GLN63 |
A | ASN90 |
A | LYS132 |
site_id | AC2 |
Number of Residues | 19 |
Details | BINDING SITE FOR RESIDUE FMN B 351 |
Chain | Residue |
B | ALA9 |
B | PRO10 |
B | MET11 |
B | VAL12 |
B | ARG14 |
B | MET36 |
B | GLN63 |
B | ASN90 |
B | LYS132 |
B | HIS164 |
B | ASN203 |
B | GLY204 |
B | GLY205 |
B | GLY225 |
B | ARG226 |
B | HOH356 |
B | HOH374 |
B | HOH407 |
B | HOH520 |
Functional Information from PROSITE/UniProt
site_id | PS01136 |
Number of Residues | 19 |
Details | UPF0034 Uncharacterized protein family UPF0034 signature. INLNlGCPsek.Aqeggy.GA |
Chain | Residue | Details |
A | ILE87-ALA105 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: Proton donor => ECO:0000305|PubMed:22123979 |
Chain | Residue | Details |
A | CYS93 | |
B | CYS93 |
site_id | SWS_FT_FI2 |
Number of Residues | 12 |
Details | BINDING: BINDING => ECO:0000269|PubMed:22123979, ECO:0007744|PDB:3B0P, ECO:0007744|PDB:3B0U, ECO:0007744|PDB:3B0V |
Chain | Residue | Details |
A | PRO10 | |
B | HIS164 | |
B | ASN203 | |
B | GLY225 | |
A | GLN63 | |
A | LYS132 | |
A | HIS164 | |
A | ASN203 | |
A | GLY225 | |
B | PRO10 | |
B | GLN63 | |
B | LYS132 |
site_id | SWS_FT_FI3 |
Number of Residues | 4 |
Details | SITE: Interacts with tRNA => ECO:0000269|PubMed:22123979 |
Chain | Residue | Details |
A | ASN90 | |
A | ARG178 | |
B | ASN90 | |
B | ARG178 |
site_id | SWS_FT_FI4 |
Number of Residues | 8 |
Details | SITE: Interacts with tRNA; defines subfamily-specific binding signature => ECO:0000269|PubMed:22123979, ECO:0000305|PubMed:25902496 |
Chain | Residue | Details |
A | LYS97 | |
A | LYS175 | |
A | ARG290 | |
A | ARG293 | |
B | LYS97 | |
B | LYS175 | |
B | ARG290 | |
B | ARG293 |