3AV7

Crystal structure of Pyrococcus horikoshii kynurenine aminotransferase in complex with PMP, KYN as substrates and KYA as products

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008483	molecular_function	transaminase activity
A	0009058	biological_process	biosynthetic process
A	0016740	molecular_function	transferase activity
A	0030170	molecular_function	pyridoxal phosphate binding
A	1901605	biological_process	alpha-amino acid metabolic process
C	0008483	molecular_function	transaminase activity
C	0009058	biological_process	biosynthetic process
C	0016740	molecular_function	transferase activity
C	0030170	molecular_function	pyridoxal phosphate binding
C	1901605	biological_process	alpha-amino acid metabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE PMP A 429

Chain	Residue
A	GLY128
A	SER268
A	LYS269
A	ARG276
C	TYR94
A	SER129
A	GLN130
A	TYR154
A	ASN208
A	ASP236
A	PRO238
A	TYR239
A	THR266

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site_id	AC2
Number of Residues	11
Details	BINDING SITE FOR RESIDUE KYN A 430

Chain	Residue
A	ARG47
A	GLY64
A	TYR154
A	LEU155
A	ALA156
A	GLN159
A	ASN208
A	ARG400
A	KYA431
A	HOH497
A	HOH595

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site_id	AC3
Number of Residues	11
Details	BINDING SITE FOR RESIDUE KYA A 431

Chain	Residue
A	SER44
A	VAL46
A	ARG47
A	LEU155
A	GLN159
A	VAL384
A	ALA388
A	ARG393
A	KYN430
A	HOH618
A	HOH766

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site_id	AC4
Number of Residues	13
Details	BINDING SITE FOR RESIDUE PMP C 429

Chain	Residue
A	TYR94
C	GLY128
C	SER129
C	GLN130
C	TYR154
C	ASN208
C	ASP236
C	PRO238
C	TYR239
C	THR266
C	SER268
C	LYS269
C	ARG276

---

site_id	AC5
Number of Residues	8
Details	BINDING SITE FOR RESIDUE KYN C 430

Chain	Residue
C	GLY64
C	LEU65
C	TYR154
C	ASN208
C	PHE389
C	ARG400
C	HOH447
C	HOH615

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site_id	AC6
Number of Residues	10
Details	BINDING SITE FOR RESIDUE KYA C 431

Chain	Residue
C	SER44
C	VAL46
C	ARG47
C	LEU155
C	GLN159
C	VAL384
C	ALA388
C	ARG393
C	HOH706
C	HOH783

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