3AV5

Crystal structure of mouse DNA methyltransferase 1 with AdoHcy

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0003682	molecular_function	chromatin binding
A	0003886	molecular_function	DNA (cytosine-5-)-methyltransferase activity
A	0005634	cellular_component	nucleus
A	0006346	biological_process	DNA methylation-dependent constitutive heterochromatin formation
A	0008168	molecular_function	methyltransferase activity
A	0008270	molecular_function	zinc ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 2001

Chain	Residue
A	CYS359
A	CYS362
A	CYS420
A	HIS424

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 2002

Chain	Residue
A	CYS656
A	CYS659
A	CYS662
A	CYS694

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 2004

Chain	Residue
A	CYS823
A	CYS897
A	CYS900
A	HIS796

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 2005

Chain	Residue
A	CYS1479
A	CYS1481
A	CYS1487
A	HIS1504

---

site_id	AC5
Number of Residues	17
Details	BINDING SITE FOR RESIDUE SAH A 1

Chain	Residue
A	PHE1148
A	SER1149
A	GLY1150
A	GLY1152
A	GLY1153
A	LEU1154
A	GLU1171
A	MET1172
A	TRP1173
A	GLU1192
A	ASP1193
A	CYS1194
A	PRO1228
A	LEU1250
A	ASN1580
A	ALA1581
A	VAL1582

---

Functional Information from PROSITE/UniProt

site_id	PS00094
Number of Residues	13
Details	C5_MTASE_1 C-5 cytosine-specific DNA methylases active site. EmLcgGpPCqGFS

Chain	Residue	Details
A	GLU1221-SER1233

---

site_id	PS00095
Number of Residues	19
Details	C5_MTASE_2 C-5 cytosine-specific DNA methylases C-terminal signature. RqvGNAVpPpLakaIgleI

Chain	Residue	Details
A	ARG1576-ILE1594

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	46
Details	ZN_FING: CXXC-type => ECO:0000255|PROSITE-ProRule:PRU00509

Chain	Residue	Details
A	ASN649-PRO695

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: ACT_SITE => ECO:0000269|PubMed:17576694

Chain	Residue	Details
A	CYS1229

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
A	CYS359
A	CYS362
A	CYS420
A	HIS424

---

site_id	SWS_FT_FI4
Number of Residues	8
Details	BINDING: BINDING => ECO:0000255|PROSITE-ProRule:PRU00509

Chain	Residue	Details
A	CYS656
A	CYS659
A	CYS662
A	CYS667
A	CYS670
A	CYS673
A	CYS689
A	CYS694

---

site_id	SWS_FT_FI5
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:21163962, ECO:0007744|PDB:3PT6, ECO:0007744|PDB:4DA4

Chain	Residue	Details
A	SER1149

---

site_id	SWS_FT_FI6
Number of Residues	3
Details	BINDING: BINDING => ECO:0000269|PubMed:21163962, ECO:0007744|PDB:3PT6, ECO:0007744|PDB:3PT9, ECO:0007744|PDB:4DA4

Chain	Residue	Details
A	GLY1153
A	GLU1171
A	VAL1582

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:21163962, ECO:0007744|PDB:3PT6, ECO:0007744|PDB:3PT9

Chain	Residue	Details
A	ASP1193

---

site_id	SWS_FT_FI8
Number of Residues	12
Details	MOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:P26358

Chain	Residue	Details
A	LYS372
A	LYS1120
A	LYS1352
A	LYS1418
A	LYS752
A	LYS895
A	LYS961
A	LYS965
A	LYS979
A	LYS1114
A	LYS1116
A	LYS1118

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0000269|PubMed:17965600, ECO:0000269|PubMed:9211941

Chain	Residue	Details
A	SER515

---

site_id	SWS_FT_FI10
Number of Residues	3
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P26358

Chain	Residue	Details
A	SER555
A	SER735
A	SER882

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:21183079

Chain	Residue	Details
A	SER713

---

site_id	SWS_FT_FI12
Number of Residues	1
Details	MOD_RES: Phosphoserine => ECO:0007744|PubMed:17242355, ECO:0007744|PubMed:19144319, ECO:0007744|PubMed:21183079

Chain	Residue	Details
A	SER717

---

site_id	SWS_FT_FI13
Number of Residues	2
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:23806337

Chain	Residue	Details
A	LYS1122
A	LYS1124

---

site_id	SWS_FT_FI14
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0000250|UniProtKB:P26358

Chain	Residue	Details
A	LYS1611

---