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3AP2

Crystal structure of human tyrosylprotein sulfotransferase-2 complexed with PAP,C4 peptide, and phosphate ion

Functional Information from GO Data
ChainGOidnamespacecontents
A0006478biological_processpeptidyl-tyrosine sulfation
A0008476molecular_functionprotein-tyrosine sulfotransferase activity
B0006478biological_processpeptidyl-tyrosine sulfation
B0008476molecular_functionprotein-tyrosine sulfotransferase activity
Functional Information from PDB Data
site_idAC1
Number of Residues20
DetailsBINDING SITE FOR RESIDUE A3P A 1
ChainResidue
AARG78
ATYR238
ASER285
AGLN288
AVAL289
ALYS291
APRO292
AVAL293
AASN294
AALA297
ALYS300
ASER79
AHOH367
AGLY80
ATHR81
ATHR82
ALEU83
AARG183
ASER191
AARG195

site_idAC2
Number of Residues21
DetailsBINDING SITE FOR RESIDUE A3P B 1
ChainResidue
BHOH5
BARG78
BSER79
BGLY80
BTHR81
BTHR82
BLEU83
BARG183
BSER191
BARG195
BTYR238
BSER285
BGLN288
BVAL289
BLYS291
BPRO292
BVAL293
BASN294
BALA297
BLYS300
BHOH363

site_idAC3
Number of Residues7
DetailsBINDING SITE FOR RESIDUE GOL B 360
ChainResidue
AGLN346
ALEU349
BLEU295
BGLU296
BLEU298
BSER299
BLYS300

site_idAC4
Number of Residues4
DetailsBINDING SITE FOR RESIDUE PO4 T 1
ChainResidue
AARG118
BLYS196
BARG284
TASP1005

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton donor/acceptor => ECO:0000305|PubMed:23481380
ChainResidueDetails
AGLU99
BGLU99

site_idSWS_FT_FI2
Number of Residues4
DetailsBINDING: BINDING => ECO:0007744|PDB:3AP1, ECO:0007744|PDB:3AP2, ECO:0007744|PDB:3AP3
ChainResidueDetails
AARG78
ASER285
BARG78
BSER285

site_idSWS_FT_FI3
Number of Residues10
DetailsBINDING: BINDING => ECO:0000305|PubMed:23481380, ECO:0007744|PDB:3AP1, ECO:0007744|PDB:3AP2, ECO:0007744|PDB:3AP3
ChainResidueDetails
AARG183
BLYS300
ASER191
AARG195
ATYR238
ALYS300
BARG183
BSER191
BARG195
BTYR238

site_idSWS_FT_FI4
Number of Residues4
DetailsSITE: Transition state stabilizer => ECO:0000305|PubMed:23481380
ChainResidueDetails
ALYS158
ASER285
BLYS158
BSER285

site_idSWS_FT_FI5
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN343
BASN343

226707

PDB entries from 2024-10-30

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