3AP2
Crystal structure of human tyrosylprotein sulfotransferase-2 complexed with PAP,C4 peptide, and phosphate ion
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE A3P A 1 |
| Chain | Residue |
| A | ARG78 |
| A | TYR238 |
| A | SER285 |
| A | GLN288 |
| A | VAL289 |
| A | LYS291 |
| A | PRO292 |
| A | VAL293 |
| A | ASN294 |
| A | ALA297 |
| A | LYS300 |
| A | SER79 |
| A | HOH367 |
| A | GLY80 |
| A | THR81 |
| A | THR82 |
| A | LEU83 |
| A | ARG183 |
| A | SER191 |
| A | ARG195 |
| site_id | AC2 |
| Number of Residues | 21 |
| Details | BINDING SITE FOR RESIDUE A3P B 1 |
| Chain | Residue |
| B | HOH5 |
| B | ARG78 |
| B | SER79 |
| B | GLY80 |
| B | THR81 |
| B | THR82 |
| B | LEU83 |
| B | ARG183 |
| B | SER191 |
| B | ARG195 |
| B | TYR238 |
| B | SER285 |
| B | GLN288 |
| B | VAL289 |
| B | LYS291 |
| B | PRO292 |
| B | VAL293 |
| B | ASN294 |
| B | ALA297 |
| B | LYS300 |
| B | HOH363 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE GOL B 360 |
| Chain | Residue |
| A | GLN346 |
| A | LEU349 |
| B | LEU295 |
| B | GLU296 |
| B | LEU298 |
| B | SER299 |
| B | LYS300 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE PO4 T 1 |
| Chain | Residue |
| A | ARG118 |
| B | LYS196 |
| B | ARG284 |
| T | ASP1005 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Region: {"description":"Interaction with peptide substrate","evidences":[{"source":"PubMed","id":"23481380","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Active site: {"description":"Proton donor/acceptor","evidences":[{"source":"PubMed","id":"23481380","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 26 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"3AP1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AP2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AP3","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"23481380","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3AP1","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AP2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AP3","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 4 |
| Details | Site: {"description":"Transition state stabilizer","evidences":[{"source":"PubMed","id":"23481380","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
