3AOE

Crystal structure of hetero-hexameric glutamate dehydrogenase from Thermus thermophilus (Leu bound form)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0004352	molecular_function	glutamate dehydrogenase (NAD+) activity
A	0004353	molecular_function	glutamate dehydrogenase [NAD(P)+] activity
A	0006520	biological_process	amino acid metabolic process
A	0006538	biological_process	glutamate catabolic process
A	0016491	molecular_function	oxidoreductase activity
A	0016639	molecular_function	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
B	0000166	molecular_function	nucleotide binding
B	0004352	molecular_function	glutamate dehydrogenase (NAD+) activity
B	0004353	molecular_function	glutamate dehydrogenase [NAD(P)+] activity
B	0006520	biological_process	amino acid metabolic process
B	0006538	biological_process	glutamate catabolic process
B	0016491	molecular_function	oxidoreductase activity
B	0016639	molecular_function	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
C	0004352	molecular_function	glutamate dehydrogenase (NAD+) activity
C	0006520	biological_process	amino acid metabolic process
C	0006538	biological_process	glutamate catabolic process
C	0016491	molecular_function	oxidoreductase activity
C	0016639	molecular_function	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
D	0004352	molecular_function	glutamate dehydrogenase (NAD+) activity
D	0006520	biological_process	amino acid metabolic process
D	0006538	biological_process	glutamate catabolic process
D	0016491	molecular_function	oxidoreductase activity
D	0016639	molecular_function	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
E	0004352	molecular_function	glutamate dehydrogenase (NAD+) activity
E	0006520	biological_process	amino acid metabolic process
E	0006538	biological_process	glutamate catabolic process
E	0016491	molecular_function	oxidoreductase activity
E	0016639	molecular_function	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor
F	0004352	molecular_function	glutamate dehydrogenase (NAD+) activity
F	0006520	biological_process	amino acid metabolic process
F	0006538	biological_process	glutamate catabolic process
F	0016491	molecular_function	oxidoreductase activity
F	0016639	molecular_function	oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE LEU A 500

Chain	Residue
A	ALA73
A	ARG417
A	ARG420
A	GLY421
A	LEU422
A	TYR423
B	ARG135
C	ASP166

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site_id	AC2
Number of Residues	7
Details	BINDING SITE FOR RESIDUE LEU B 500

Chain	Residue
B	ALA73
B	ARG417
B	ARG420
B	GLY421
B	TYR423
F	ASP166
A	ARG135

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site_id	AC3
Number of Residues	7
Details	BINDING SITE FOR RESIDUE LEU E 500

Chain	Residue
A	ASP167
E	TYR38
E	ILE71
E	GLY416
E	VAL417
E	TYR418
F	ARG134

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site_id	AC4
Number of Residues	6
Details	BINDING SITE FOR RESIDUE LEU F 500

Chain	Residue
D	ASP166
E	ARG134
F	TYR38
F	GLY416
F	VAL417
F	TYR418

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site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE LEU C 500

Chain	Residue
C	TYR38
C	ILE71
C	GLY416
C	TYR418
D	ARG134
E	ASP166

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site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE LEU D 500

Chain	Residue
B	ASP167
C	ARG134
D	TYR38
D	ARG415
D	GLY416
D	VAL417
D	TYR418

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Functional Information from PROSITE/UniProt

site_id	PS00074
Number of Residues	14
Details	GLFV_DEHYDROGENASE Glu / Leu / Phe / Val dehydrogenases active site. LpyGGGKgGirvDP

Chain	Residue	Details
A	LEU108-PRO121

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