3ANZ
Crystal Structure of alpha-hemolysin
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| a | 0005576 | cellular_component | extracellular region |
| a | 0035821 | biological_process | modulation of process of another organism |
| a | 0051715 | biological_process | cytolysis in another organism |
| a | 0090729 | molecular_function | toxin activity |
| A | 0005576 | cellular_component | extracellular region |
| A | 0035821 | biological_process | modulation of process of another organism |
| A | 0051715 | biological_process | cytolysis in another organism |
| A | 0090729 | molecular_function | toxin activity |
| b | 0005576 | cellular_component | extracellular region |
| b | 0035821 | biological_process | modulation of process of another organism |
| b | 0051715 | biological_process | cytolysis in another organism |
| b | 0090729 | molecular_function | toxin activity |
| B | 0005576 | cellular_component | extracellular region |
| B | 0035821 | biological_process | modulation of process of another organism |
| B | 0051715 | biological_process | cytolysis in another organism |
| B | 0090729 | molecular_function | toxin activity |
| C | 0005576 | cellular_component | extracellular region |
| C | 0035821 | biological_process | modulation of process of another organism |
| C | 0051715 | biological_process | cytolysis in another organism |
| C | 0090729 | molecular_function | toxin activity |
| D | 0005576 | cellular_component | extracellular region |
| D | 0035821 | biological_process | modulation of process of another organism |
| D | 0051715 | biological_process | cytolysis in another organism |
| D | 0090729 | molecular_function | toxin activity |
| E | 0005576 | cellular_component | extracellular region |
| E | 0035821 | biological_process | modulation of process of another organism |
| E | 0051715 | biological_process | cytolysis in another organism |
| E | 0090729 | molecular_function | toxin activity |
| F | 0005576 | cellular_component | extracellular region |
| F | 0035821 | biological_process | modulation of process of another organism |
| F | 0051715 | biological_process | cytolysis in another organism |
| F | 0090729 | molecular_function | toxin activity |
| G | 0005576 | cellular_component | extracellular region |
| G | 0035821 | biological_process | modulation of process of another organism |
| G | 0051715 | biological_process | cytolysis in another organism |
| G | 0090729 | molecular_function | toxin activity |
| H | 0005576 | cellular_component | extracellular region |
| H | 0035821 | biological_process | modulation of process of another organism |
| H | 0051715 | biological_process | cytolysis in another organism |
| H | 0090729 | molecular_function | toxin activity |
| I | 0005576 | cellular_component | extracellular region |
| I | 0035821 | biological_process | modulation of process of another organism |
| I | 0051715 | biological_process | cytolysis in another organism |
| I | 0090729 | molecular_function | toxin activity |
| J | 0005576 | cellular_component | extracellular region |
| J | 0035821 | biological_process | modulation of process of another organism |
| J | 0051715 | biological_process | cytolysis in another organism |
| J | 0090729 | molecular_function | toxin activity |
| K | 0005576 | cellular_component | extracellular region |
| K | 0035821 | biological_process | modulation of process of another organism |
| K | 0051715 | biological_process | cytolysis in another organism |
| K | 0090729 | molecular_function | toxin activity |
| L | 0005576 | cellular_component | extracellular region |
| L | 0035821 | biological_process | modulation of process of another organism |
| L | 0051715 | biological_process | cytolysis in another organism |
| L | 0090729 | molecular_function | toxin activity |
| M | 0005576 | cellular_component | extracellular region |
| M | 0035821 | biological_process | modulation of process of another organism |
| M | 0051715 | biological_process | cytolysis in another organism |
| M | 0090729 | molecular_function | toxin activity |
| N | 0005576 | cellular_component | extracellular region |
| N | 0035821 | biological_process | modulation of process of another organism |
| N | 0051715 | biological_process | cytolysis in another organism |
| N | 0090729 | molecular_function | toxin activity |
| O | 0005576 | cellular_component | extracellular region |
| O | 0035821 | biological_process | modulation of process of another organism |
| O | 0051715 | biological_process | cytolysis in another organism |
| O | 0090729 | molecular_function | toxin activity |
| P | 0005576 | cellular_component | extracellular region |
| P | 0035821 | biological_process | modulation of process of another organism |
| P | 0051715 | biological_process | cytolysis in another organism |
| P | 0090729 | molecular_function | toxin activity |
| Q | 0005576 | cellular_component | extracellular region |
| Q | 0035821 | biological_process | modulation of process of another organism |
| Q | 0051715 | biological_process | cytolysis in another organism |
| Q | 0090729 | molecular_function | toxin activity |
| R | 0005576 | cellular_component | extracellular region |
| R | 0035821 | biological_process | modulation of process of another organism |
| R | 0051715 | biological_process | cytolysis in another organism |
| R | 0090729 | molecular_function | toxin activity |
| S | 0005576 | cellular_component | extracellular region |
| S | 0035821 | biological_process | modulation of process of another organism |
| S | 0051715 | biological_process | cytolysis in another organism |
| S | 0090729 | molecular_function | toxin activity |
| T | 0005576 | cellular_component | extracellular region |
| T | 0035821 | biological_process | modulation of process of another organism |
| T | 0051715 | biological_process | cytolysis in another organism |
| T | 0090729 | molecular_function | toxin activity |
| U | 0005576 | cellular_component | extracellular region |
| U | 0035821 | biological_process | modulation of process of another organism |
| U | 0051715 | biological_process | cytolysis in another organism |
| U | 0090729 | molecular_function | toxin activity |
| V | 0005576 | cellular_component | extracellular region |
| V | 0035821 | biological_process | modulation of process of another organism |
| V | 0051715 | biological_process | cytolysis in another organism |
| V | 0090729 | molecular_function | toxin activity |
| W | 0005576 | cellular_component | extracellular region |
| W | 0035821 | biological_process | modulation of process of another organism |
| W | 0051715 | biological_process | cytolysis in another organism |
| W | 0090729 | molecular_function | toxin activity |
| X | 0005576 | cellular_component | extracellular region |
| X | 0035821 | biological_process | modulation of process of another organism |
| X | 0051715 | biological_process | cytolysis in another organism |
| X | 0090729 | molecular_function | toxin activity |
| Y | 0005576 | cellular_component | extracellular region |
| Y | 0035821 | biological_process | modulation of process of another organism |
| Y | 0051715 | biological_process | cytolysis in another organism |
| Y | 0090729 | molecular_function | toxin activity |
| Z | 0005576 | cellular_component | extracellular region |
| Z | 0035821 | biological_process | modulation of process of another organism |
| Z | 0051715 | biological_process | cytolysis in another organism |
| Z | 0090729 | molecular_function | toxin activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MPD A 302 |
| Chain | Residue |
| A | ASN176 |
| A | GLN177 |
| A | TRP179 |
| A | MET197 |
| A | LYS198 |
| A | ARG200 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MPD A 303 |
| Chain | Residue |
| G | HIS144 |
| G | LEU146 |
| A | TRP179 |
| A | GLY180 |
| F | SER114 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MPD B 302 |
| Chain | Residue |
| B | ASN176 |
| B | TRP179 |
| B | GLN194 |
| B | MET197 |
| B | LYS198 |
| B | ARG200 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MPD B 303 |
| Chain | Residue |
| B | ASN178 |
| B | TRP179 |
| B | GLY180 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MPD C 302 |
| Chain | Residue |
| C | ASN176 |
| C | GLN177 |
| C | TRP179 |
| C | MET197 |
| C | ARG200 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MPD C 303 |
| Chain | Residue |
| B | LEU146 |
| C | TRP179 |
| C | GLY180 |
| site_id | AC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MPD D 302 |
| Chain | Residue |
| D | ASN176 |
| D | GLN177 |
| D | TRP179 |
| D | GLN194 |
| D | MET197 |
| D | LYS198 |
| D | ARG200 |
| site_id | AC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MPD D 303 |
| Chain | Residue |
| B | SER114 |
| C | LEU146 |
| D | ASN178 |
| D | TRP179 |
| D | GLY180 |
| site_id | AC9 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE MPD E 302 |
| Chain | Residue |
| E | GLN177 |
| E | TRP179 |
| E | TYR182 |
| E | GLN194 |
| E | MET197 |
| E | LYS198 |
| E | THR199 |
| E | ARG200 |
| site_id | BC1 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE MPD E 303 |
| Chain | Residue |
| E | ASN178 |
| E | GLY180 |
| site_id | BC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MPD F 302 |
| Chain | Residue |
| F | ASN176 |
| F | TRP179 |
| F | GLN194 |
| F | MET197 |
| F | LYS198 |
| F | ARG200 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MPD F 303 |
| Chain | Residue |
| D | LEU116 |
| E | LEU146 |
| F | TRP179 |
| F | GLY180 |
| site_id | BC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MPD G 302 |
| Chain | Residue |
| G | ASN176 |
| G | TRP179 |
| G | GLN194 |
| G | MET197 |
| G | LYS198 |
| G | ARG200 |
| site_id | BC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MPD G 303 |
| Chain | Residue |
| F | LEU146 |
| G | TRP179 |
| G | GLY180 |
| site_id | BC6 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MPD H 302 |
| Chain | Residue |
| H | ASN176 |
| H | GLN177 |
| H | TRP179 |
| H | GLN194 |
| H | MET197 |
| H | LYS198 |
| H | ARG200 |
| site_id | BC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MPD H 303 |
| Chain | Residue |
| H | TRP179 |
| H | GLY180 |
| M | SER114 |
| M | LEU116 |
| N | HIS144 |
| site_id | BC8 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MPD I 302 |
| Chain | Residue |
| I | ASN176 |
| I | GLN177 |
| I | TRP179 |
| I | GLN194 |
| I | MET197 |
| I | LYS198 |
| I | ARG200 |
| site_id | BC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MPD I 303 |
| Chain | Residue |
| I | ASN178 |
| I | TRP179 |
| I | GLY180 |
| N | SER114 |
| site_id | CC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MPD J 302 |
| Chain | Residue |
| J | ASN176 |
| J | GLN177 |
| J | MET197 |
| J | ARG200 |
| site_id | CC2 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MPD J 303 |
| Chain | Residue |
| I | HIS144 |
| J | TRP179 |
| J | GLY180 |
| site_id | CC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MPD K 302 |
| Chain | Residue |
| K | ASN176 |
| K | TRP179 |
| K | GLN194 |
| K | MET197 |
| K | LYS198 |
| K | ARG200 |
| site_id | CC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MPD K 303 |
| Chain | Residue |
| I | SER114 |
| K | ASN178 |
| K | TRP179 |
| K | GLY180 |
| site_id | CC5 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MPD L 302 |
| Chain | Residue |
| L | ASN176 |
| L | GLN177 |
| L | GLN194 |
| L | MET197 |
| L | LYS198 |
| L | ARG200 |
| site_id | CC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MPD L 303 |
| Chain | Residue |
| J | SER114 |
| J | LEU116 |
| K | TYR112 |
| L | GLY180 |
| site_id | CC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MPD M 302 |
| Chain | Residue |
| M | ASN176 |
| M | TRP179 |
| M | GLN194 |
| M | MET197 |
| M | LYS198 |
| M | THR199 |
| M | ARG200 |
| site_id | CC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MPD M 303 |
| Chain | Residue |
| K | SER114 |
| L | LEU146 |
| M | ASN178 |
| M | TRP179 |
| M | GLY180 |
| site_id | CC9 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MPD N 302 |
| Chain | Residue |
| N | ASN176 |
| N | GLN177 |
| N | TRP179 |
| N | GLN194 |
| N | MET197 |
| N | LYS198 |
| N | ARG200 |
| site_id | DC1 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MPD N 303 |
| Chain | Residue |
| M | LEU146 |
| N | TRP179 |
| N | GLY180 |
| site_id | DC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MPD O 302 |
| Chain | Residue |
| O | ASN176 |
| O | GLN177 |
| O | MET197 |
| O | LYS198 |
| O | ARG200 |
| site_id | DC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MPD O 303 |
| Chain | Residue |
| O | ASN178 |
| O | TRP179 |
| O | GLY180 |
| U | LEU146 |
| site_id | DC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MPD P 302 |
| Chain | Residue |
| P | ASN176 |
| P | GLN177 |
| P | TRP179 |
| P | MET197 |
| P | LYS198 |
| P | ARG200 |
| site_id | DC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MPD P 303 |
| Chain | Residue |
| P | TRP179 |
| P | GLY180 |
| U | SER114 |
| site_id | DC6 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE MPD Q 302 |
| Chain | Residue |
| Q | ASN176 |
| Q | TRP179 |
| Q | TYR182 |
| Q | GLN194 |
| Q | MET197 |
| Q | LYS198 |
| Q | THR199 |
| Q | ARG200 |
| site_id | DC7 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MPD Q 303 |
| Chain | Residue |
| Q | ASN178 |
| Q | TRP179 |
| Q | GLY180 |
| site_id | DC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MPD R 302 |
| Chain | Residue |
| R | ASN176 |
| R | TRP179 |
| R | GLN194 |
| R | MET197 |
| R | LYS198 |
| R | ARG200 |
| site_id | DC9 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MPD R 303 |
| Chain | Residue |
| P | LEU116 |
| R | ASN178 |
| R | TRP179 |
| R | GLY180 |
| site_id | EC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MPD S 302 |
| Chain | Residue |
| S | ASN176 |
| S | TRP179 |
| S | MET197 |
| S | LYS198 |
| S | ARG200 |
| site_id | EC2 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MPD S 303 |
| Chain | Residue |
| Q | SER114 |
| R | LEU146 |
| S | ASN178 |
| S | TRP179 |
| S | GLY180 |
| site_id | EC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MPD T 302 |
| Chain | Residue |
| T | ASN176 |
| T | GLN177 |
| T | GLN194 |
| T | MET197 |
| T | LYS198 |
| T | ARG200 |
| site_id | EC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MPD T 303 |
| Chain | Residue |
| R | SER114 |
| S | HIS144 |
| S | LEU146 |
| T | ASN178 |
| T | TRP179 |
| T | GLY180 |
| site_id | EC5 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MPD U 302 |
| Chain | Residue |
| U | ASN176 |
| U | GLN177 |
| U | TRP179 |
| U | MET197 |
| U | LYS198 |
| U | THR199 |
| U | ARG200 |
| site_id | EC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MPD U 303 |
| Chain | Residue |
| S | SER114 |
| T | LEU146 |
| U | ASN178 |
| U | TRP179 |
| U | GLY180 |
| site_id | EC7 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MPD V 302 |
| Chain | Residue |
| V | ASN176 |
| V | GLN194 |
| V | MET197 |
| V | LYS198 |
| V | THR199 |
| V | ARG200 |
| site_id | EC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MPD V 303 |
| Chain | Residue |
| V | TRP179 |
| V | GLY180 |
| a | LEU116 |
| b | HIS144 |
| site_id | EC9 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MPD W 302 |
| Chain | Residue |
| W | ASN176 |
| W | TRP179 |
| W | MET197 |
| W | LYS198 |
| W | THR199 |
| W | ARG200 |
| site_id | FC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MPD W 303 |
| Chain | Residue |
| W | ASN178 |
| W | TRP179 |
| W | GLY180 |
| b | SER114 |
| site_id | FC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MPD X 302 |
| Chain | Residue |
| X | GLN177 |
| X | TRP179 |
| X | GLN194 |
| X | MET197 |
| X | LYS198 |
| X | THR199 |
| X | ARG200 |
| site_id | FC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MPD X 303 |
| Chain | Residue |
| V | ILE142 |
| X | ASN178 |
| X | TRP179 |
| X | GLY180 |
| site_id | FC4 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MPD Y 302 |
| Chain | Residue |
| Y | ASN176 |
| Y | GLN177 |
| Y | TRP179 |
| Y | GLN194 |
| Y | MET197 |
| Y | LYS198 |
| Y | ARG200 |
| site_id | FC5 |
| Number of Residues | 3 |
| Details | BINDING SITE FOR RESIDUE MPD Y 303 |
| Chain | Residue |
| W | SER114 |
| Y | TRP179 |
| Y | GLY180 |
| site_id | FC6 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MPD Z 302 |
| Chain | Residue |
| Z | ASN176 |
| Z | GLN177 |
| Z | TRP179 |
| Z | MET197 |
| Z | LYS198 |
| Z | ARG200 |
| site_id | FC7 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MPD X 304 |
| Chain | Residue |
| X | SER114 |
| X | THR115 |
| X | LEU116 |
| Y | LEU146 |
| Z | ASN178 |
| Z | TRP179 |
| Z | GLY180 |
| site_id | FC8 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MPD a 302 |
| Chain | Residue |
| a | ASN176 |
| a | TRP179 |
| a | GLN194 |
| a | MET197 |
| a | LYS198 |
| a | ARG200 |
| site_id | FC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MPD a 303 |
| Chain | Residue |
| Y | SER114 |
| Y | LEU116 |
| a | TRP179 |
| a | GLY180 |
| a | HOH1865 |
| site_id | GC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MPD b 302 |
| Chain | Residue |
| b | TRP179 |
| b | TYR182 |
| b | GLN194 |
| b | MET197 |
| b | ARG200 |
| site_id | GC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE MPD b 303 |
| Chain | Residue |
| a | LEU146 |
| b | ASN178 |
| b | TRP179 |
| b | GLY180 |
| site_id | GC3 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE ACY A 304 |
| Chain | Residue |
| A | ALA138 |
| site_id | GC4 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE ACY D 304 |
| Chain | Residue |
| D | ALA138 |
| site_id | GC5 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE ACY F 304 |
| Chain | Residue |
| F | GLY122 |
| G | ALA138 |
| site_id | GC6 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE ACY J 304 |
| Chain | Residue |
| J | ALA138 |
| site_id | GC7 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE ACY K 304 |
| Chain | Residue |
| K | ALA138 |
| site_id | GC8 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE ACY O 304 |
| Chain | Residue |
| O | ALA138 |
| site_id | GC9 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE ACY P 304 |
| Chain | Residue |
| P | HOH1597 |
| site_id | HC1 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE ACY S 304 |
| Chain | Residue |
| S | ALA138 |
| site_id | HC2 |
| Number of Residues | 1 |
| Details | BINDING SITE FOR RESIDUE ACY S 305 |
| Chain | Residue |
| S | ASN121 |
| site_id | HC3 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE ACY T 304 |
| Chain | Residue |
| T | ASN121 |
| T | GLY122 |
Functional Information from PROSITE/UniProt
| site_id | PS00274 |
| Number of Residues | 10 |
| Details | AEROLYSIN Aerolysin type toxins signature. TstNWkgTNT |
| Chain | Residue | Details |
| A | THR261-THR270 |
