Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

3AMZ

Bovine Xanthine Oxidoreductase urate bound form

Functional Information from GO Data
ChainGOidnamespacecontents
A0002197cellular_componentxanthine dehydrogenase complex
A0004854molecular_functionxanthine dehydrogenase activity
A0004855molecular_functionxanthine oxidase activity
A0005506molecular_functioniron ion binding
A0005576cellular_componentextracellular region
A0005615cellular_componentextracellular space
A0005737cellular_componentcytoplasm
A0005777cellular_componentperoxisome
A0009115biological_processxanthine catabolic process
A0016491molecular_functionoxidoreductase activity
A0030151molecular_functionmolybdenum ion binding
A0042803molecular_functionprotein homodimerization activity
A0043546molecular_functionmolybdopterin cofactor binding
A0046872molecular_functionmetal ion binding
A0050660molecular_functionflavin adenine dinucleotide binding
A0051536molecular_functioniron-sulfur cluster binding
A0051537molecular_function2 iron, 2 sulfur cluster binding
A0071949molecular_functionFAD binding
B0002197cellular_componentxanthine dehydrogenase complex
B0004854molecular_functionxanthine dehydrogenase activity
B0004855molecular_functionxanthine oxidase activity
B0005506molecular_functioniron ion binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005737cellular_componentcytoplasm
B0005777cellular_componentperoxisome
B0009115biological_processxanthine catabolic process
B0016491molecular_functionoxidoreductase activity
B0030151molecular_functionmolybdenum ion binding
B0042803molecular_functionprotein homodimerization activity
B0043546molecular_functionmolybdopterin cofactor binding
B0046872molecular_functionmetal ion binding
B0050660molecular_functionflavin adenine dinucleotide binding
B0051536molecular_functioniron-sulfur cluster binding
B0051537molecular_function2 iron, 2 sulfur cluster binding
B0071949molecular_functionFAD binding
Functional Information from PDB Data
site_idAC1
Number of Residues8
DetailsBINDING SITE FOR RESIDUE FES A 3001
ChainResidue
AGLN112
ACYS113
AGLY114
ACYS116
ACYS148
AARG149
ACYS150
ALEU744

site_idAC2
Number of Residues10
DetailsBINDING SITE FOR RESIDUE FES A 3002
ChainResidue
ACYS43
AGLY44
AGLY46
AGLY47
ACYS48
AGLY49
ACYS51
AASN71
ACYS73
AGLY42

site_idAC3
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA A 3008
ChainResidue
AALA867
ASER870
AARG871
ASER874
ASER907
AASN908

site_idAC4
Number of Residues32
DetailsBINDING SITE FOR RESIDUE FAD A 3005
ChainResidue
AGLY46
ALYS256
ALEU257
AVAL258
AVAL259
AGLY260
AASN261
ATHR262
AGLU263
AILE264
AALA301
APHE337
AALA338
AALA346
ASER347
AGLY350
AASN351
AILE353
ATHR354
ASER359
AASP360
AILE403
ALEU404
ALYS422
AASP429
ANAI1333
AHOH1585
AHOH1618
AHOH1641
AHOH1796
AHOH2052
AHOH2103

site_idAC5
Number of Residues23
DetailsBINDING SITE FOR RESIDUE NAI A 1333
ChainResidue
AGLU263
ALYS271
ASER356
APRO357
AILE358
ATYR393
AARG394
AASP429
AASP430
AILE431
AGLY458
AALA460
AASP461
APRO501
AGLY502
AARG508
ASER1225
AHOH1670
AHOH1738
AHOH1861
AHOH1915
AHOH2103
AFAD3005

site_idAC6
Number of Residues9
DetailsBINDING SITE FOR RESIDUE BCT A 1334
ChainResidue
AARG839
AHIS840
AILE877
ATHR909
AALA910
APHE911
APHE914
AGLY915
AGLN918

site_idAC7
Number of Residues7
DetailsBINDING SITE FOR RESIDUE GOL A 1335
ChainResidue
AASP594
APHE604
AARG824
ACYS825
AMET826
AHOH1553
AHOH2053

site_idAC8
Number of Residues11
DetailsBINDING SITE FOR RESIDUE GOL A 1336
ChainResidue
AILE835
AASN869
ASER906
ASER907
AHOH1949
AHOH2244
AHOH2262
AHIS665
AILE666
AARG804
ALEU807

site_idAC9
Number of Residues21
DetailsBINDING SITE FOR RESIDUE MTE A 1337
ChainResidue
AGLN112
ACYS150
AGLY796
AGLY797
APHE798
AGLY799
AARG912
AMET1038
AGLY1039
AGLN1040
AALA1078
AALA1079
ASER1080
AVAL1081
ASER1082
AGLN1194
AMOS1338
AURC1339
AHOH1746
AHOH2127
AHOH2151

site_idBC1
Number of Residues9
DetailsBINDING SITE FOR RESIDUE MOS A 1338
ChainResidue
AGLN767
AGLY799
APHE911
AARG912
ATHR1077
AALA1078
AGLU1261
AMTE1337
AURC1339

site_idBC2
Number of Residues13
DetailsBINDING SITE FOR RESIDUE URC A 1339
ChainResidue
AGLU802
AARG880
APHE914
APHE1009
ATHR1010
AALA1078
AALA1079
AGLU1261
AMTE1337
AMOS1338
AHOH1889
AHOH2106
AHOH2338

site_idBC3
Number of Residues7
DetailsBINDING SITE FOR RESIDUE FES B 4001
ChainResidue
BGLN112
BCYS113
BGLY114
BCYS116
BCYS148
BARG149
BCYS150

site_idBC4
Number of Residues10
DetailsBINDING SITE FOR RESIDUE FES B 4002
ChainResidue
BGLY42
BCYS43
BGLY44
BGLY46
BGLY47
BCYS48
BGLY49
BCYS51
BASN71
BCYS73

site_idBC5
Number of Residues6
DetailsBINDING SITE FOR RESIDUE CA B 4008
ChainResidue
BALA867
BSER870
BARG871
BSER874
BSER907
BASN908

site_idBC6
Number of Residues32
DetailsBINDING SITE FOR RESIDUE FAD B 4005
ChainResidue
BGLY46
BLYS256
BLEU257
BVAL258
BVAL259
BGLY260
BASN261
BTHR262
BGLU263
BILE264
BALA301
BPHE337
BALA338
BVAL342
BALA346
BSER347
BGLY350
BASN351
BILE353
BTHR354
BSER359
BASP360
BILE403
BLEU404
BLYS422
BASP429
BNAI1333
BHOH1619
BHOH1694
BHOH1867
BHOH1999
BHOH2098

site_idBC7
Number of Residues26
DetailsBINDING SITE FOR RESIDUE NAI B 1333
ChainResidue
BGLU263
BLYS271
BSER356
BPRO357
BILE358
BTYR393
BARG394
BASP429
BASP430
BILE431
BGLY458
BALA460
BASP461
BPRO501
BGLY502
BARG508
BSER1225
BHOH1392
BHOH1599
BHOH1619
BHOH1755
BHOH2129
BHOH2316
BHOH2327
BHOH2328
BFAD4005

site_idBC8
Number of Residues9
DetailsBINDING SITE FOR RESIDUE BCT B 1334
ChainResidue
BARG839
BHIS840
BILE877
BTHR909
BALA910
BPHE911
BPHE914
BGLY915
BGLN918

site_idBC9
Number of Residues6
DetailsBINDING SITE FOR RESIDUE GOL B 1335
ChainResidue
BASP594
BPHE604
BPRO675
BCYS825
BMET826
BHOH2333

site_idCC1
Number of Residues21
DetailsBINDING SITE FOR RESIDUE MTE B 1336
ChainResidue
BGLN112
BCYS150
BGLY796
BGLY797
BPHE798
BGLY799
BARG912
BMET1038
BGLY1039
BGLN1040
BALA1078
BALA1079
BSER1080
BVAL1081
BSER1082
BGLN1194
BMOS1337
BURC1338
BHOH1375
BHOH1417
BHOH1688

site_idCC2
Number of Residues9
DetailsBINDING SITE FOR RESIDUE MOS B 1337
ChainResidue
BGLN767
BGLY799
BPHE911
BARG912
BTHR1077
BALA1078
BGLU1261
BMTE1336
BURC1338

site_idCC3
Number of Residues13
DetailsBINDING SITE FOR RESIDUE URC B 1338
ChainResidue
BGLU802
BARG880
BPHE914
BPHE1009
BTHR1010
BALA1078
BALA1079
BGLU1261
BMTE1336
BMOS1337
BHOH2077
BHOH2318
BHOH2319

Functional Information from PROSITE/UniProt
site_idPS00197
Number of Residues9
Details2FE2S_FER_1 2Fe-2S ferredoxin-type iron-sulfur binding region signature. CGEGGCGAC
ChainResidueDetails
ACYS43-CYS51

site_idPS00559
Number of Residues36
DetailsMOLYBDOPTERIN_EUK Eukaryotic molybdopterin oxidoreductases signature. GFggKetrstlvsvava..LaayKTghpVrCmlDRneD
ChainResidueDetails
AGLY797-ASP832

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: Proton acceptor => ECO:0000269|PubMed:15148401
ChainResidueDetails
AGLU1261
BGLU1261

site_idSWS_FT_FI2
Number of Residues24
DetailsBINDING: BINDING => ECO:0000269|PubMed:12421831, ECO:0000269|PubMed:15148401, ECO:0000269|PubMed:19109252
ChainResidueDetails
ACYS43
APHE798
AARG912
AALA1079
BCYS43
BCYS48
BCYS51
BCYS73
BCYS113
BCYS116
BCYS148
ACYS48
BCYS150
BGLN767
BPHE798
BARG912
BALA1079
ACYS51
ACYS73
ACYS113
ACYS116
ACYS148
ACYS150
AGLN767

site_idSWS_FT_FI3
Number of Residues12
DetailsBINDING: BINDING => ECO:0000269|PubMed:12421831, ECO:0000269|PubMed:15148401
ChainResidueDetails
ALEU257
BASP360
BLEU404
BLYS422
APHE337
ASER347
AASP360
ALEU404
ALYS422
BLEU257
BPHE337
BSER347

site_idSWS_FT_FI4
Number of Residues8
DetailsBINDING:
ChainResidueDetails
AGLU802
AARG880
APHE914
ATHR1010
BGLU802
BARG880
BPHE914
BTHR1010

Catalytic Information from CSA
site_idMCSA1
Number of Residues3
DetailsM-CSA 139
ChainResidueDetails
AGLU802electrostatic stabiliser, hydrogen bond acceptor
AARG880electrostatic stabiliser, hydrogen bond donor
AGLU1261electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor

site_idMCSA2
Number of Residues3
DetailsM-CSA 139
ChainResidueDetails
BGLU802electrostatic stabiliser, hydrogen bond acceptor
BARG880electrostatic stabiliser, hydrogen bond donor
BGLU1261electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor

site_idMCSA3
Number of Residues3
DetailsM-CSA 987
ChainResidueDetails
AGLU802electrostatic stabiliser
AARG880proton donor
AGLU1261proton acceptor

227111

PDB entries from 2024-11-06

PDB statisticsPDBj update infoContact PDBjnumon