3AHQ
hyperactive human Ero1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0015035 | molecular_function | protein-disulfide reductase activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016972 | molecular_function | thiol oxidase activity |
| A | 0034975 | biological_process | protein folding in endoplasmic reticulum |
| A | 0071949 | molecular_function | FAD binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 25 |
| Details | BINDING SITE FOR RESIDUE FAD A 1 |
| Chain | Residue |
| A | ARG187 |
| A | SER252 |
| A | HIS255 |
| A | ALA256 |
| A | ILE258 |
| A | ASN259 |
| A | LEU262 |
| A | LYS276 |
| A | TRP277 |
| A | ARG287 |
| A | ARG300 |
| A | TYR188 |
| A | MET389 |
| A | CYS397 |
| A | HOH470 |
| A | HOH482 |
| A | HOH488 |
| A | HOH493 |
| A | THR189 |
| A | TYR191 |
| A | ALA196 |
| A | TRP197 |
| A | TRP200 |
| A | TYR204 |
| A | TYR248 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 7 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:20834232, ECO:0007744|PDB:3AHQ, ECO:0007744|PDB:3AHR |
| Chain | Residue | Details |
| A | ARG187 | |
| A | THR189 | |
| A | TRP200 | |
| A | SER252 | |
| A | HIS255 | |
| A | ARG287 | |
| A | ARG300 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | SER106 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:20068231, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER143 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by FAM20C => ECO:0000269|PubMed:29858230 |
| Chain | Residue | Details |
| A | SER145 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218 |
| Chain | Residue | Details |
| A | ASN280 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN384 |
