3AF5

The crystal structure of an archaeal CPSF subunit, PH1404 from Pyrococcus horikoshii

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0003677	molecular_function	DNA binding
A	0003723	molecular_function	RNA binding
A	0004518	molecular_function	nuclease activity
A	0004519	molecular_function	endonuclease activity
A	0004521	molecular_function	RNA endonuclease activity
A	0004527	molecular_function	exonuclease activity
A	0004532	molecular_function	RNA exonuclease activity
A	0006351	biological_process	DNA-templated transcription
A	0006353	biological_process	DNA-templated transcription termination
A	0008270	molecular_function	zinc ion binding
A	0016787	molecular_function	hydrolase activity
A	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 652

Chain	Residue
A	ARG202
A	TYR229
A	LYS230
A	HIS234
A	ASN644
A	ARG649
A	ARG651

---

site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 653

Chain	Residue
A	GLY119
A	LYS117
A	PRO118

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 654

Chain	Residue
A	HIS258
A	ILE345
A	GLY434
A	ARG435
A	HOH677
A	HOH730

---

site_id	AC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 655

Chain	Residue
A	ARG198
A	ARG613
A	ASN643

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 656

Chain	Residue
A	ARG336
A	HIS352
A	HIS354
A	ASN361
A	PRO384
A	ARG385

---

site_id	AC6
Number of Residues	7
Details	BINDING SITE FOR RESIDUE SO4 A 657

Chain	Residue
A	VAL200
A	ASP260
A	ASP367
A	HIS594
A	HIS618
A	ZN662
A	ZN665

---

site_id	AC7
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ACY A 658

Chain	Residue
A	ASN341
A	GLU377
A	GLU474
A	TYR475
A	LEU476
A	GLU573

---

site_id	AC8
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ACY A 659

Chain	Residue
A	PRO310
A	ARG311

---

site_id	AC9
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ACY A 660

Chain	Residue
A	ILE321
A	THR322

---

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE ACY A 661

Chain	Residue
A	ASP324
A	TYR325
A	GLU474
A	TYR475
A	GLU573

---

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ZN A 662

Chain	Residue
A	HIS256
A	HIS258
A	HIS344
A	ASP367
A	SO4657
A	ZN665

---

site_id	BC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE ZN A 663

Chain	Residue
A	GLU387
A	GLU612

---

site_id	BC4
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ZN A 664

Chain	Residue
A	ASP12
A	HIS498
A	GLU505

---

site_id	BC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE ZN A 665

Chain	Residue
A	ASP260
A	HIS261
A	ASP367
A	HIS618
A	SO4657
A	ZN662

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	67
Details	Region: {"description":"KHb","evidences":[{"source":"HAMAP-Rule","id":"MF_00870","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"20544974","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	210
Details	Region: {"description":"Metallo-beta-lactamase N-terminus","evidences":[{"source":"HAMAP-Rule","id":"MF_00870","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	193
Details	Region: {"description":"Beta-Casp","evidences":[{"source":"HAMAP-Rule","id":"MF_00870","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	58
Details	Region: {"description":"Metallo-beta-lactamase C-terminus","evidences":[{"source":"HAMAP-Rule","id":"MF_00870","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	7
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00870","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"20544974","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3AF5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AF6","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---