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3ADT

Human PPARgamma ligand-binding domain in complex with 5-hydroxy-indole acetate

Functional Information from GO Data
ChainGOidnamespacecontents
A0003677molecular_functionDNA binding
A0004879molecular_functionnuclear receptor activity
A0005634cellular_componentnucleus
A0006355biological_processregulation of DNA-templated transcription
B0003677molecular_functionDNA binding
B0004879molecular_functionnuclear receptor activity
B0005634cellular_componentnucleus
B0006355biological_processregulation of DNA-templated transcription
Functional Information from PDB Data
site_idAC1
Number of Residues10
DetailsBINDING SITE FOR RESIDUE HID A 2
ChainResidue
ACYS285
ATYR473
AGLN286
ASER289
AHIS323
ATYR327
ALEU330
APHE363
AMET364
AHIS449

site_idAC2
Number of Residues10
DetailsBINDING SITE FOR RESIDUE HID A 3
ChainResidue
ATYR222
APRO227
ALEU228
ATHR229
ALYS230
AARG288
AGLU295
AMET329
ASER332
ALEU333

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsBINDING: BINDING => ECO:0000269|PubMed:9744270, ECO:0007744|PDB:2PRG
ChainResidueDetails
BHIS449
BTYR473
AGLN286
AHIS323
AHIS449
ATYR473
BGLN286
BHIS323

site_idSWS_FT_FI2
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:36737649
ChainResidueDetails
ALYS224
BLYS224

218500

PDB entries from 2024-04-17

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