3ABS

Crystal structure of ethanolamine ammonia-lyase from Escherichia coli complexed with adeninylpentylcobalamin and ethanolamine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005829	cellular_component	cytosol
A	0006520	biological_process	amino acid metabolic process
A	0008851	molecular_function	ethanolamine ammonia-lyase activity
A	0009350	cellular_component	ethanolamine ammonia-lyase complex
A	0016829	molecular_function	lyase activity
A	0031419	molecular_function	cobalamin binding
A	0031469	cellular_component	bacterial microcompartment
A	0031471	cellular_component	ethanolamine degradation polyhedral organelle
A	0046336	biological_process	ethanolamine catabolic process
B	0006520	biological_process	amino acid metabolic process
B	0008851	molecular_function	ethanolamine ammonia-lyase activity
B	0009350	cellular_component	ethanolamine ammonia-lyase complex
B	0016829	molecular_function	lyase activity
B	0031419	molecular_function	cobalamin binding
B	0031469	cellular_component	bacterial microcompartment
B	0031471	cellular_component	ethanolamine degradation polyhedral organelle
B	0046336	biological_process	ethanolamine catabolic process
C	0005829	cellular_component	cytosol
C	0006520	biological_process	amino acid metabolic process
C	0008851	molecular_function	ethanolamine ammonia-lyase activity
C	0009350	cellular_component	ethanolamine ammonia-lyase complex
C	0016829	molecular_function	lyase activity
C	0031419	molecular_function	cobalamin binding
C	0031469	cellular_component	bacterial microcompartment
C	0031471	cellular_component	ethanolamine degradation polyhedral organelle
C	0046336	biological_process	ethanolamine catabolic process
D	0006520	biological_process	amino acid metabolic process
D	0008851	molecular_function	ethanolamine ammonia-lyase activity
D	0009350	cellular_component	ethanolamine ammonia-lyase complex
D	0016829	molecular_function	lyase activity
D	0031419	molecular_function	cobalamin binding
D	0031469	cellular_component	bacterial microcompartment
D	0031471	cellular_component	ethanolamine degradation polyhedral organelle
D	0046336	biological_process	ethanolamine catabolic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	38
Details	BINDING SITE FOR RESIDUE COY A 601

Chain	Residue
A	ASN193
A	PHE258
A	GLU287
A	THR288
A	GLY289
A	SER295
A	VAL326
A	PHE329
A	ILE330
A	MET401
A	LEU402
A	PRO194
A	HOH475
A	HOH507
A	HOH540
A	HOH607
A	HOH609
A	HOH663
B	ARG141
B	ARG206
B	VAL207
B	GLU228
A	VAL195
B	ARG229
B	TYR241
B	GLU253
B	ARG256
B	CYS258
B	SER260
B	HOH307
B	HOH317
B	HOH574
A	LEU225
A	ALA226
A	PHE245
A	GLN246
A	SER247
A	GLU257

---

site_id	AC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE ETA A 602

Chain	Residue
A	ARG160
A	GLN162
A	ASN193
A	LEU225
A	GLU287
A	ASP362
A	MET392
A	LEU402
A	TYR404

---

site_id	AC3
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL A 2001

Chain	Residue
A	GLY272
A	ALA273
A	GLY280
A	GLU281
A	ASN282
A	CYS283
A	HOH653
A	HOH712
C	LYS115

---

site_id	AC4
Number of Residues	10
Details	BINDING SITE FOR RESIDUE GOL A 2002

Chain	Residue
A	ASN81
A	LYS115
C	GLY272
C	ALA273
C	GLY280
C	GLU281
C	ASN282
C	CYS283
C	HOH568
C	HOH570

---

site_id	AC5
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL A 2004

Chain	Residue
A	ARG114
A	LYS145
A	ARG316
A	GLY356

---

site_id	AC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE GOL A 2005

Chain	Residue
A	ILE76
A	ARG114
A	LEU117
A	THR118
A	SER119
A	SER355
A	HOH621
A	HOH664
A	HOH694

---

site_id	AC7
Number of Residues	37
Details	BINDING SITE FOR RESIDUE COY C 601

Chain	Residue
C	HOH553
C	HOH571
C	ETA602
C	HOH632
C	HOH645
C	HOH659
C	HOH687
D	ARG141
D	ARG206
D	VAL207
D	GLU228
D	ARG229
D	TYR241
D	GLU253
D	ARG256
D	CYS258
D	SER260
C	ASN193
C	PRO194
C	VAL195
C	ALA226
C	PHE245
C	GLN246
C	SER247
C	GLU257
C	PHE258
C	GLU287
C	THR288
C	GLY289
C	SER295
C	VAL326
C	PHE329
C	ILE330
C	MET401
C	LEU402
C	HOH531
C	HOH547

---

site_id	AC8
Number of Residues	10
Details	BINDING SITE FOR RESIDUE ETA C 602

Chain	Residue
C	ARG160
C	GLN162
C	ASN193
C	LEU225
C	GLU287
C	ASP362
C	MET392
C	LEU402
C	TYR404
C	COY601

---

site_id	AC9
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 C 2000

Chain	Residue
A	PHE112
C	ASN148
C	ARG277
C	HOH644

---

site_id	BC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE GOL C 2003

Chain	Residue
C	ARG114
C	LYS145
C	ARG316
C	GLY356

---

site_id	BC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE GOL C 2006

Chain	Residue
C	PRO154
C	THR156
C	ARG422
C	HOH569
C	HOH605
C	HOH669

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00861","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"20519496","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21142024","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3ABO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ABS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ANY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AO0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00861","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"20519496","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21142024","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3ABO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ABS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AO0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00861","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"29797764","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3ABR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5YSN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5YSR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00861","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"20519496","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21142024","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3ABO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ABQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ANY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5YSN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00861","evidenceCode":"ECO:0000255"},{"evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3ABR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ANY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AO0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00861","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"20519496","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21142024","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3ABO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ABQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ANY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5YSN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5YSR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00601","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"20519496","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21142024","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3ABO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ABQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ABR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5YSN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5YSR","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00601","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"20519496","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21142024","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3ABO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ABQ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ABR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ANY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AO0","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_00601","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"20519496","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"21142024","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3ABO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3ABR","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"3AO0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5YSN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---