3AB2

Crystal structure of aspartate kinase from Corynebacterium glutamicum in complex with threonine

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004072	molecular_function	aspartate kinase activity
A	0005829	cellular_component	cytosol
A	0008652	biological_process	amino acid biosynthetic process
A	0009088	biological_process	L-threonine biosynthetic process
A	0009089	biological_process	obsolete L-lysine biosynthetic process via diaminopimelate
A	0009090	biological_process	L-homoserine biosynthetic process
C	0004072	molecular_function	aspartate kinase activity
C	0005829	cellular_component	cytosol
C	0008652	biological_process	amino acid biosynthetic process
C	0009088	biological_process	L-threonine biosynthetic process
C	0009089	biological_process	obsolete L-lysine biosynthetic process via diaminopimelate
C	0009090	biological_process	L-homoserine biosynthetic process
E	0004072	molecular_function	aspartate kinase activity
E	0005829	cellular_component	cytosol
E	0008652	biological_process	amino acid biosynthetic process
E	0009088	biological_process	L-threonine biosynthetic process
E	0009089	biological_process	obsolete L-lysine biosynthetic process via diaminopimelate
E	0009090	biological_process	L-homoserine biosynthetic process
G	0004072	molecular_function	aspartate kinase activity
G	0005829	cellular_component	cytosol
G	0008652	biological_process	amino acid biosynthetic process
G	0009088	biological_process	L-threonine biosynthetic process
G	0009089	biological_process	obsolete L-lysine biosynthetic process via diaminopimelate
G	0009090	biological_process	L-homoserine biosynthetic process
I	0004072	molecular_function	aspartate kinase activity
I	0005829	cellular_component	cytosol
I	0008652	biological_process	amino acid biosynthetic process
I	0009088	biological_process	L-threonine biosynthetic process
I	0009089	biological_process	obsolete L-lysine biosynthetic process via diaminopimelate
I	0009090	biological_process	L-homoserine biosynthetic process
K	0004072	molecular_function	aspartate kinase activity
K	0005829	cellular_component	cytosol
K	0008652	biological_process	amino acid biosynthetic process
K	0009088	biological_process	L-threonine biosynthetic process
K	0009089	biological_process	obsolete L-lysine biosynthetic process via diaminopimelate
K	0009090	biological_process	L-homoserine biosynthetic process
M	0004072	molecular_function	aspartate kinase activity
M	0005829	cellular_component	cytosol
M	0008652	biological_process	amino acid biosynthetic process
M	0009088	biological_process	L-threonine biosynthetic process
M	0009089	biological_process	obsolete L-lysine biosynthetic process via diaminopimelate
M	0009090	biological_process	L-homoserine biosynthetic process
O	0004072	molecular_function	aspartate kinase activity
O	0005829	cellular_component	cytosol
O	0008652	biological_process	amino acid biosynthetic process
O	0009088	biological_process	L-threonine biosynthetic process
O	0009089	biological_process	obsolete L-lysine biosynthetic process via diaminopimelate
O	0009090	biological_process	L-homoserine biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	BINDING SITE FOR RESIDUE THR A 501

Chain	Residue
A	ASP274
A	LYS275
A	GLY277
A	GLU278
A	ALA279
A	GLN298
B	ASN125
B	ILE126

---

site_id	AC2
Number of Residues	10
Details	BINDING SITE FOR RESIDUE THR B 501

Chain	Residue
A	ILE375
B	ASP25
B	LYS26
B	PRO27
B	GLY28
B	GLU29
B	ALA30
B	GLN49
B	HOH230
A	ASN374

---

site_id	AC3
Number of Residues	8
Details	BINDING SITE FOR RESIDUE THR C 501

Chain	Residue
C	ASP274
C	LYS275
C	PRO276
C	GLY277
C	GLU278
C	ALA279
C	GLN298
D	ILE126

---

site_id	AC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE THR D 501

Chain	Residue
C	ASN374
C	ILE375
D	ASP25
D	LYS26
D	GLY28
D	GLU29
D	ALA30
D	GLN49
D	HOH221

---

site_id	AC5
Number of Residues	11
Details	BINDING SITE FOR RESIDUE THR E 501

Chain	Residue
E	ASP274
E	LYS275
E	PRO276
E	GLY277
E	GLU278
E	ALA279
E	GLN298
E	THR308
E	HOH513
F	ASN125
F	ILE126

---

site_id	AC6
Number of Residues	11
Details	BINDING SITE FOR RESIDUE THR F 501

Chain	Residue
E	ASN374
E	ILE375
E	HOH524
F	SER24
F	ASP25
F	LYS26
F	GLY28
F	GLU29
F	ALA30
F	GLN49
F	HOH220

---

site_id	AC7
Number of Residues	8
Details	BINDING SITE FOR RESIDUE THR G 501

Chain	Residue
G	ASP274
G	LYS275
G	GLY277
G	GLU278
G	ALA279
G	GLN298
H	ASN125
H	ILE126

---

site_id	AC8
Number of Residues	11
Details	BINDING SITE FOR RESIDUE THR H 501

Chain	Residue
G	ASN374
G	ILE375
H	ILE23
H	ASP25
H	LYS26
H	GLY28
H	GLU29
H	ALA30
H	GLN49
H	THR59
H	HOH218

---

site_id	AC9
Number of Residues	9
Details	BINDING SITE FOR RESIDUE THR J 501

Chain	Residue
I	ASN374
I	ILE375
J	ASP25
J	LYS26
J	PRO27
J	GLY28
J	GLU29
J	ALA30
J	GLN49

---

site_id	BC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE THR K 501

Chain	Residue
K	ASP274
K	LYS275
K	GLY277
K	GLU278
K	ALA279
K	GLN298
K	THR308
K	ILE310
K	HOH518
L	ASN125
L	ILE126

---

site_id	BC2
Number of Residues	9
Details	BINDING SITE FOR RESIDUE THR L 501

Chain	Residue
L	LYS26
L	GLY28
L	GLU29
L	ALA30
L	GLN49
L	HOH222
K	ASN374
K	ILE375
L	ASP25

---

site_id	BC3
Number of Residues	10
Details	BINDING SITE FOR RESIDUE THR M 501

Chain	Residue
M	ILE272
M	ASP274
M	LYS275
M	PRO276
M	GLY277
M	GLU278
M	ALA279
M	GLN298
N	ASN125
N	ILE126

---

site_id	BC4
Number of Residues	9
Details	BINDING SITE FOR RESIDUE THR N 501

Chain	Residue
M	ASN374
M	ILE375
N	ASP25
N	LYS26
N	GLY28
N	GLU29
N	ALA30
N	GLN49
N	HOH224

---

site_id	BC5
Number of Residues	10
Details	BINDING SITE FOR RESIDUE THR O 501

Chain	Residue
O	ASP274
O	LYS275
O	GLY277
O	GLU278
O	ALA279
O	GLN298
O	HOH511
O	HOH522
P	ASN125
P	ILE126

---

site_id	BC6
Number of Residues	9
Details	BINDING SITE FOR RESIDUE THR P 501

Chain	Residue
O	ASN374
O	ILE375
P	SER24
P	ASP25
P	LYS26
P	GLY28
P	GLU29
P	ALA30
P	GLN49

---

Functional Information from PROSITE/UniProt

site_id	PS00324
Number of Residues	9
Details	ASPARTOKINASE Aspartokinase signature. VqKYGGSSL

Chain	Residue	Details
A	VAL5-LEU13

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	178
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	216
Details	Binding site: {}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	16
Details	Site: {"description":"Contribution to the catalysis","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	684
Details	Domain: {"description":"ACT 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU01007","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---