3AAW
Crystal structure of aspartate kinase from Corynebacterium glutamicum in complex with lysine and threonine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004072 | molecular_function | aspartate kinase activity |
| A | 0005524 | molecular_function | ATP binding |
| A | 0005829 | cellular_component | cytosol |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0009085 | biological_process | lysine biosynthetic process |
| A | 0009088 | biological_process | threonine biosynthetic process |
| A | 0009089 | biological_process | lysine biosynthetic process via diaminopimelate |
| A | 0009090 | biological_process | homoserine biosynthetic process |
| A | 0016301 | molecular_function | kinase activity |
| A | 0019877 | biological_process | diaminopimelate biosynthetic process |
| B | 0003824 | molecular_function | catalytic activity |
| B | 0004072 | molecular_function | aspartate kinase activity |
| B | 0005829 | cellular_component | cytosol |
| B | 0009088 | biological_process | threonine biosynthetic process |
| B | 0009089 | biological_process | lysine biosynthetic process via diaminopimelate |
| B | 0009090 | biological_process | homoserine biosynthetic process |
| B | 0016301 | molecular_function | kinase activity |
| C | 0004072 | molecular_function | aspartate kinase activity |
| C | 0005524 | molecular_function | ATP binding |
| C | 0005829 | cellular_component | cytosol |
| C | 0008652 | biological_process | amino acid biosynthetic process |
| C | 0009085 | biological_process | lysine biosynthetic process |
| C | 0009088 | biological_process | threonine biosynthetic process |
| C | 0009089 | biological_process | lysine biosynthetic process via diaminopimelate |
| C | 0009090 | biological_process | homoserine biosynthetic process |
| C | 0016301 | molecular_function | kinase activity |
| C | 0019877 | biological_process | diaminopimelate biosynthetic process |
| D | 0003824 | molecular_function | catalytic activity |
| D | 0004072 | molecular_function | aspartate kinase activity |
| D | 0005829 | cellular_component | cytosol |
| D | 0009088 | biological_process | threonine biosynthetic process |
| D | 0009089 | biological_process | lysine biosynthetic process via diaminopimelate |
| D | 0009090 | biological_process | homoserine biosynthetic process |
| D | 0016301 | molecular_function | kinase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE THR B 201 |
| Chain | Residue |
| A | ASN374 |
| B | HOH205 |
| A | ILE375 |
| B | ASP25 |
| B | LYS26 |
| B | GLY28 |
| B | GLU29 |
| B | ALA30 |
| B | GLN49 |
| B | HOH204 |
| site_id | AC2 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE THR A 501 |
| Chain | Residue |
| A | ASP274 |
| A | LYS275 |
| A | GLY277 |
| A | GLU278 |
| A | ALA279 |
| A | GLN298 |
| A | HOH716 |
| A | HOH717 |
| B | ASN125 |
| B | ILE126 |
| site_id | AC3 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE LYS A 601 |
| Chain | Residue |
| A | MET354 |
| A | LYS355 |
| A | HIS357 |
| A | GLY359 |
| A | VAL360 |
| A | THR361 |
| A | THR380 |
| A | SER381 |
| A | HOH672 |
| A | HOH770 |
| B | ASN43 |
| B | ILE44 |
| B | ASP45 |
| B | HOH195 |
| site_id | AC4 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE THR D 201 |
| Chain | Residue |
| C | ASN374 |
| C | ILE375 |
| C | HOH715 |
| D | ASP25 |
| D | LYS26 |
| D | GLY28 |
| D | GLU29 |
| D | ALA30 |
| D | GLN49 |
| D | HOH618 |
| site_id | AC5 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE LYS C 601 |
| Chain | Residue |
| C | MET354 |
| C | HIS357 |
| C | GLY359 |
| C | VAL360 |
| C | THR361 |
| C | SER381 |
| C | GLU382 |
| C | HOH677 |
| C | HOH739 |
| D | ASN43 |
| D | ILE44 |
| D | ASP45 |
| site_id | AC6 |
| Number of Residues | 11 |
| Details | BINDING SITE FOR RESIDUE THR C 501 |
| Chain | Residue |
| C | ASP274 |
| C | LYS275 |
| C | GLY277 |
| C | GLU278 |
| C | ALA279 |
| C | GLN298 |
| C | THR308 |
| C | HOH678 |
| C | HOH679 |
| D | ASN125 |
| D | ILE126 |
| site_id | AC7 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE LYS C 701 |
| Chain | Residue |
| C | LYS7 |
| C | GLY10 |
| C | SER41 |
| C | GLU74 |
| C | ARG151 |
| C | GLY153 |
| C | SER154 |
| C | ASP155 |
Functional Information from PROSITE/UniProt
| site_id | PS00324 |
| Number of Residues | 9 |
| Details | ASPARTOKINASE Aspartokinase signature. VqKYGGSSL |
| Chain | Residue | Details |
| A | VAL5-LEU13 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 20 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | LYS7 | |
| A | ASP274 | |
| C | LYS7 | |
| C | ARG25 | |
| C | SER41 | |
| C | GLU74 | |
| C | LEU125 | |
| C | ARG151 | |
| C | SER174 | |
| C | TYR180 | |
| C | LYS210 | |
| A | ARG25 | |
| C | ASP274 | |
| A | SER41 | |
| A | GLU74 | |
| A | LEU125 | |
| A | ARG151 | |
| A | SER174 | |
| A | TYR180 | |
| A | LYS210 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 14 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | ASP45 | |
| C | ASN292 | |
| C | GLN298 | |
| C | VAL360 | |
| C | ASN374 | |
| C | SER381 | |
| A | SER154 | |
| A | ASN292 | |
| A | GLN298 | |
| A | VAL360 | |
| A | ASN374 | |
| A | SER381 | |
| C | ASP45 | |
| C | SER154 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | SITE: Contribution to the catalysis => ECO:0000250 |
| Chain | Residue | Details |
| A | LYS7 | |
| A | GLU74 | |
| C | LYS7 | |
| C | GLU74 |
